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Targeted panel sequencing in pediatric primary cardiomyopathy supports a critical role of TNNI3
(2019)
The underlying genetic mechanisms and early pathological events of children with primary cardiomyopathy (CMP) are insufficiently characterized. In this study, we aimed to characterize the mutational spectrum of primary CMP in a large cohort of patients ≤18 years referred to a tertiary center. Eighty unrelated index patients with pediatric primary CMP underwent genetic testing with a panel-based next-generation sequencing approach of 89 genes. At least one pathogenic or probably pathogenic variant was identified in 30/80 (38%) index patients. In all CMP subgroups, patients carried most frequently variants of interest in sarcomere genes suggesting them as a major contributor in pediatric primary CMP. In MYH7, MYBPC3, and TNNI3, we identified 18 pathogenic/probably pathogenic variants (MYH7 n = 7, MYBPC3 n = 6, TNNI3 n = 5, including one homozygous (TNNI3 c.24+2T>A) truncating variant. Protein and transcript level analysis on heart biopsies from individuals with homozygous mutation of TNNI3 revealed that the TNNI3 protein is absent and associated with upregulation of the fetal isoform TNNI1. The present study further supports the clinical importance of sarcomeric mutation-not only in adult-but also in pediatric primary CMP. TNNI3 is the third most important disease gene in this cohort and complete loss of TNNI3 leads to severe pediatric CMP.
This feasibility study investigates the flexural properties of biocomposites containing woven flax textiles (plain, twill, satin) and woven twill patterned hybrid textiles containing flax-/glass or flax-/carbon mixture for lightweight applications. Synthetic fibers are integrated as weft and flax fibers are integrated as warp yarns using a double-rapier weaving machine with a Jacquard attachment. The corresponding biocomposites are manufactured via vacuum infusion process using a biobased epoxy resin as a matrix. The manufactured biocomposites are analyzed with regard to their density and flexural properties. The results show that the use of hybrid textiles offers a promising solution for the manufacture of biocomposites with a higher biobased content and significantly improved flexural properties. Furthermore, the introduction of high-performance synthetic fibers in textiles enables the manufacture of biocomposites with an isotropic mechanical performance.
Background:
Promoting patient and occupational safety are two key challenges for hospitals. When aiming to improve these two outcomes synergistically, psychosocial working conditions, leadership by hospital management and supervisors, and perceptions of patient and occupational safety climate have to be considered. Recent studies have shown that these key topics are interrelated and form a critical foundation for promoting patient and occupational safety in hospitals. So far, these topics have mainly been studied independently from each other. The present study investigated hospital staffs’ perceptions of four different topics: (1) psychosocial working conditions, (2) leadership, (3) patient safety climate, and (4) occupational safety climate. We present results from a survey in two German university hospitals aiming to detect differences between nurses and physicians.
Methods:
We performed a cross-sectional study using a standardized paper-based questionnaire. The survey was conducted with nurses and physicians to assess the four topics. The instruments mainly consisted of scales of the German version of the COPSOQ (Copenhagen Psychosocial Questionnaire), one scale of the Copenhagen Burnout Inventory (CBI), scales to assess leadership and transformational leadership, scales to assess patient safety climate using the Hospital Survey on Patient Safety Culture (HSPSC), and analogous items to assess occupational safety climate.
Results:
A total of 995 completed questionnaires out of 2512 distributed questionnaires were returned anonymously. The overall response rate was 39.6%. The sample consisted of 381 physicians and 567 nurses. We found various differences with regard to the four topics. In most of the COPSOQ and the HSPSC-scales, physicians rated psychosocial working conditions and patient safety climate more positively than nurses. With regard to occupational safety, nurses
indicated higher occupational risks than physicians.
Conclusions:
The WorkSafeMed study combined the assessment of the four topics psychosocial working conditions, leadership, patient safety climate, and occupational safety climate in hospitals. Looking at the four topics provides an overview of where improvements in hospitals may be needed for nurses and physicians. Based on these results,
improvements in working conditions, patient safety climate, and occupational safety climate are required for health care professionals in German university hospitals – especially for nurses.
Bibliotheken sind Lernorte. Der interne Organisationsaufbau von Bibliotheken weist hingegen bisher wenige Strukturen einer Lernenden Organisation auf. Um die Bereitstellung von Medien und Informationen für Bibliotheksnutzer aufrechtzuerhalten und stetig an deren Bedürfnissen auszurichten (z. B. im Kontext der fortschreitenden Digitalisierung), bedarf es eines gut ausgebildeten Bibliothekspersonals. Klassische Fortbildungskonzepte gehören ebenso dazu, wie der kontinuierliche, persönliche Lernprozess eines jeden Bibliotheksmitarbeiters. Die Methode „Working Out Loud“ kann eingesetzt werden, um diese persönlichen Fähigkeiten auszubauen und eine agile Arbeitsweise anzuregen. Daher wird überprüft, inwiefern Working Out Loud die Lernende Organisation unterstützen kann. Zunächst wird die Methode Working Out Loud und deren Anwendung bei Unternehmen vorgestellt. Dann werden die Kennzeichen von Lernenden Organisationen definiert und auf Bibliotheken angewandt. Angeschlossen wird eine Betrachtung des zwölf Wochenprogramms von Working Out Loud und deren Potential zur Unterstützung der Lernenden Bibliothek. Working Out Loud vermittelt Bibliotheksmitarbeitern durch gezielte Übungen eine offenere Arbeitseinstellung, die sie mit ihren Kollegen innerhalb und außerhalb der Bibliothek zu teilen lernen.
Dieser Text soll das Verfassen von Bachelorarbeiten erleichtern. Schrittweise wird dargestellt, wie man recherchiert, wie man eine Bachelorarbeit strukturiert, wie man argumentiert, wie man Ergebnisse darstellt und wie man eine zielführende Diskussion führt. Zwei Meilensteine für eine gute Bachelorarbeit sind das eigenständige Strukturieren von Informationen sowie das Entwickeln einer Argumentationslinie. Informationen sollen nicht unverbunden nebeneinander stehen, sondern argumentativ verknüpft werden. Es werden abschließend Grundregeln des Darstellens und Zitierens erläutert.
In der vorliegenden Bachelorarbeit wird thematisiert, wie Coding zu Zwecken der sich im Umbruch befindenden MINT-Bildung eingesetzt werden kann und welche Kompetenzen durch das Erlernen von Programmierfähigkeiten gefördert werden. Darüber hinaus wird ein Bezug zur Informatik als Herkunftswissenschaft des Coding hergestellt und die Relevanz einer frühzeitigen Aneignung von Programmierfähigkeiten in einer digitalen Gesellschaft beleuchtet. Eine Analyse der webbasierten Programmierplattformen Open Roberta Lab, Scratch, Sprite Lab von Code.org und TurtleCoder, die zur Vermittlung von Programmier-fähigkeiten bei Kindern genutzt werden können, gibt Aufschluss darüber, ob sich die benannten Programmierplattformen auch für den Einsatz in außerschulischen Bildungseinrichtungen, wie etwa öffentliche Bibliotheken, eignen.
Das Thema Elektromagnetische Verträglichkeit (EMV) ist noch immer ein wesentlicher Aspekt bei der Planung, bei der Installation und beim Betrieb von Automatisierungssystemen. Kommunikationsnetzwerke wie zum Beispiel PROFIBUS und PROFINET sind als robuste und zuverlässige Übertragungssysteme bekannt. Dennoch ist für deren Funktion die Beachtung einiger grundlegender Prinzipien wichtig, um einen störungsfreien Betrieb über ein langes Anlagenleben zu gewährleisten. Der Beitrag beschreibt zunächst einige Grundlagen der EMV. Basierend auf diesen Grundlagen werden dann sechs Handlungsempfehlungen abgeleitet, die bei der Planung eines Automatisierungssystems für den Einsatz in der Fertigungsindustrie zu beachten sind. Abschließend wird ein Ausblick auf die weiterführenden Arbeiten für Anlagen der Prozessindustrie gegeben.
The objective of this study was to investigate the association between teat skin colonization and intramammary infection (IMI) with Staphylococcus aureus or Streptococcus agalactiae at the quarter level in herds with automatic milking systems. Milk and teat skin samples from 1,142 quarters were collected from 300 cows with somatic cell count >200,000 cells/mL from 8 herds positive for Strep. agalactiae. All milk and teat skin samples were cultured on calf blood agar and selective media. A subset of samples from 287 quarters was further analyzed using a PCR assay (Mastit4 PCR; DNA Diagnostic A/S, Risskov, Denmark). Bacterial culture detected Staph. aureus in 93 (8.1%) of the milk samples and 75 (6.6%) of the teat skin samples. Of these, 15 (1.3%) quarters were positive in both the teat skin and milk samples. Streptococcus agalactiae was cultured in 84 (7.4%) of the milk samples and 4 (0.35%) of the teat skin samples. Of these, 3 (0.26%) quarters were positive in both the teat skin and milk samples. The PCR detected Staph. aureus in 29 (10%) of the milk samples and 45 (16%) of the teat skin samples. Of these, 2 (0.7%) quarters were positive in both the teat skin and milk samples. Streptococcus agalactiae was detected in 40 (14%) of the milk samples and 51 (18%) of the teat skin samples. Of these, 16 (5.6%) quarters were positive in both the teat skin and milk samples. Logistic regression was used to investigate the association between teat skin colonization and IMI at the quarter level. Based on bacterial culture results, teat skin colonization with Staph. aureus resulted in 7.8 (95% confidence interval: 2.9; 20.6) times higher odds of Staph. aureus IMI, whereas herd was observed as a major confounder. However, results from the PCR analyses did not support this association. Streptococcus agalactiae was isolated from the teat skin with both PCR and bacterial culture, but the number of positive teat skin samples detected by culture was too low to proceed with further analysis. Based on the PCR results, Strep. agalactiae on teat skin resulted in 3.8 (1.4; 10.1) times higher odds of Strep. agalactiae IMI. Our results suggest that Staph. aureus and Strep. agalactiae on teat skin may be a risk factor for IMI with the same pathogens. Focus on proper teat skin hygiene is therefore recommended also in AMS.
Sustainable tourism is a niche market that has been growing in recent years. At the same time, companies in the mass tourism market have increasingly marketed themselves with a “green” image, although this market is not sustainable. In order to successfully market sustainability, targeted marketing tactics are needed.
The aim of this research is to establish appropriate marketing tactics for sustainable tourism in the niche market and in the mass market. The purpose is to uncover current marketing tactics for both the mass tourism market and the sustainable tourism niche market. It also intends to explore how consumers who are more interested in sustainability differ from consumers with less interest in sustainability in terms of their perception of sustainability in tourism. Furthermore, this research paper will assess the trustworthiness of sustainable travel offers and the trustworthiness of quality seals in sustainable tourism. For this purpose, an online survey was conducted, which was addressed at German-speaking consumers. The survey showed, that consumers with more general interest in sustainability also consider sustainability to be more relevant in tourism. Offers for sustainable travel and quality seals were perceived as not very trustworthy. Moreover, no link could be found between the interest in sustainability and the perception of trustworthiness.
On the basis of the above, it is advisable to directly advertise sustainability in the niche market and to mention sustainability in the mass market only as an accompaniment or not at all. Further research could be undertaken to identify which factors influence the trustworthiness of offers, and trustworthiness of quality seals in sustainable tourism.
Content-Gestaltung und Einsatzmöglichkeiten von Augmented Reality in Öffentlichen Bibliotheken
(2019)
Augmented Reality (AR), die Erweiterung der Realität durch computergenerierte Zusatzobjekte, kommt bisher hauptsächlich in Wissenschaftlichen Bibliotheken (WB) zum Einsatz. Diese Arbeit beschäftigt sich deshalb mit den Einsatzmöglichkeiten von AR in Öffentlichen Bibliotheken (ÖB). Betrachtet wird dabei die Realisierung von AR über eigenständig gestalteten Content mittels Anbietern im Internet und dazugehörigen Browser-Apps. Dies stellt eine kostengünstige und barrierefreie Alternative zur Programmierung von Apps dar. Dafür wird zunächst ein theoretischer Überblick gegeben, indem AR definiert wird und die technischen Grundlagen, wie Trackingverfahren und Interfaces, erläutert werden. Darauf folgen, zur Un-termauerung der Diskrepanz zwischen WB und ÖB, Beispiele für umgesetzte Projekte aus beiden Sparten. Anschließend wird auf die allgemeinen Einsatzgebiete und Potenziale von AR sowie die Aufgaben von ÖBs eingegangen. Die daraus abgeleiteten Einsatzmöglichkeiten von AR für Öffentliche Bibliotheken, Navigation und Orientierung, Bestandserweiterung, Veranstaltungen, Öffentlichkeitsarbeit/Marketing/Werbung sowie Informationskompetenz, werden erläutert. Zur Content-Gestaltung werden zunächst Grundvoraussetzungen genannt und die Funktionsweise der AR-Anbieter im Internet erklärt. Im Anschluss werden die Anbieter Blippar, HP Reveal, Layar, ROAR, Wikitude und Zappar, auf Grundlage eines zuvor erstellten Kriterienkatalogs, hinsichtlich ihres Funktionsumfangs verglichen. Im Ergebnis zeigt sich, dass sich die Anbieter zwar alle ähneln, bezüglich spezieller Funktionen und Kosten aber unterscheiden. Am besten schneidet dabei Zappar ab. Ergänzend werden danach die verschiedenen Arten von Content näher betrachtet. Zur Veranschaulichung der leichten Realisierbarkeit von AR werden zwei praktische Beispiele umgesetzt. Zum Abschluss werden Grenzen und Probleme, auch aus rechtlicher Perspektive, betrachtet. Diese schränken die Content-Gestaltung und die Einsatzmöglichkeiten nur wenig ein, womit die Content-Gestaltung von AR für den Einsatz in ÖBs sehr gut geeignet ist.
Background: Compromised immune function, associated with human immune deficiency virus (HIV) infection, is improved by antiretroviral therapy (ART) which also decreases bone mineral density (BMD), and possibly the quality of life (QoL). However, physical (aerobic/resistance) exercises, were reported to induce reverse effects in uninfected individuals and were appraised in the literature for evidence of similar benefits in people living with HIV/AIDS(PLWHA). The main study objective was to evaluate the impact of physical (aerobic and resistance) exercises on CD4+ count,
BMD and QoL in PLWHA.
Methods: A systematic review was conducted using the Cochrane Collaboration protocol. Searching databases, up to June 2017, only randomized control trials investigating the effects of either aerobic, resistance or a combination of both exercise types with a control/other intervention(s) for a period of at least 4 weeks among adults living with HIV, were included. Two independent reviewers determined the eligibility of the studies. Data were extracted and risk of bias (ROB) was assessed with the Cochrane Collaboration ROB tool. Meta-analyses were conducted using random effect models using the Review Manager (RevMan) computer software.
Results: Nineteen studies met inclusion criteria(n = 491 participants at study completion) comprising male and female with age range 22–66 years. Two meta-analyses across 13 sub-group comparisons were performed. However, there were no RCTs on the impact of physical exercises on BMD in PLWHA. The result showed no significant change in CD4+ count unlike a significant effect of 5.04 point (95%CI:-8.49,-3.74,p = 0.00001) for role activity limitation due to physical health (QoL sub-domain). Overall, the GRADE evidence for this review was of moderate quality.
Conclusions: There was evidence that engaging in moderate intensity aerobic exercises (55–85% Maximum heart rate-MHR), for 30–60 min, two to five times/week for 6–24 weeks significantly improves role activity limitation due to physical health problems, otherwise physical(aerobic or/and resistance) exercises have no significant effects on CD4+ count and other domains of QoL. Also, there is lack of evidence on the impact of exercises on BMD in PLWHA due to the paucity of RCTs. The moderate grade evidence for this review suggests that further research may likely have an important impact on our confidence in the estimate of effects and may change the estimate.
Mastitis poses a considerable threat to productivity and to animal welfare on modern dairy farms. However, the common way of antibiotic treatment does not always lead to a cure. Unsuccessful cures can, among other reasons, occur due to biofilm formation of the causative agent. This has attracted interest from researchers to introduce promising alternative therapeutic approaches, such as the use of beneficial lactic acid bacteria (LAB). In fact, using LAB for treating mastitis probably requires the formation of a beneficial biofilm by the probiotic bacteria. The present study investigated the ability of five LAB strains, selected on the basis of results from previous studies, to remove and to replace pathogenic biofilms in vitro. For this purpose, Staphylococcus (S.) aureus ATCC 12,600 and two strains—S. xylosus (35/07) and S. epidermidis (575/08)—belonging to the group of coagulase negative staphylococci (CNS) were allowed to form biofilms in a 96-well plate. Subsequently, the LAB were added to the well. The biofilm challenge was evaluated by scraping off and suspending the biofilm cells, followed by a plate count of serial dilutions using selective media. All the LAB strains successfully removed the staphylococcal biofilms. However, only Lactobacillus (L.) rhamnosus ATCC 7469 and L. plantarum 2/37 formed biofilms of their own to replace the pathogenic ones.
Mit der Hannoverschen Korruptionsskala Österreich-Version (kurz: HKS 38 Ö) kann die Einstellung zu Korruption gemessen werden. Die HKS 38 Ö ist eine Adaption der Hannoverschen Korruptionsskala (kurz: HKS 38) für den österreichischen Sprachraum. Die testtheoretische Überprüfung der HKS 38 Ö wird unter anderem in diesem Manual beschrieben. Die HKS 38 Ö umfasst 38 Items, die den Einstellungskomponenten kognitiv, affektiv und konativ zugeordnet werden können. Innerhalb dieses Manuals werden drei Datenerhebungen geschildert. In der ersten Datenerhebung (n = 1.617) wurde geprüft, ob die HKS 38 grundsätzlich für eine Anwendung in Österreich geeignet ist und ähnlich zuverlässige Messungen wie in Deutschland ermöglicht. Die Erfahrungen aus der ersten Datenerhebung – insbesondere die Hinweise von Testpersonen zur sprachlichen Verständlichkeit – führten zur Erstellung der HKS 38 Ö. Die HKS 38 Ö wurde im Rahmen einer zweiten Datenerhebung entsprechend der klassischen Testtheorie überprüft und auf Basis einer bevölkerungsrepräsentativen Telefonbefragung in Österreich (n ≈ 867) normiert. Neu im Vergleich zur ersten Auflage des Manuals ist die dritte Datenerhebung, in der die HKS 38 Ö für eine Befragung von Polizeischülern (n = 1.455) verwendet wurde. Auch die Daten der dritten Erhebung wurden testtheoretisch überprüft. Die HKS 38 Ö eignet sich zur Befragung von Testpersonen ab einem Alter von 18 Jahren.
The topic of electromagnetic compatibility (EMC) remains an important aspect during the planning, installation and operation of automation systems. Communication networks, such as PROFIBUS and PROFINET, are known to be robust and reliable transmission systems. Nevertheless, it is important that a number of fundamental principles needs to be observed to ensure fault-free operation over a long plant lifetime. This paper first describes a number of principles of EMC. On the basis of these principles, six recommendations for action are then developed which are to be observed during the planning of an automation system for use in the manufacturing industry. Finally, an overview is provided of future work for systems in the process industry.
Concreteness of words has been studied extensively in psycholinguistic literature. A number of datasets have been created with average values for perceived concreteness of words. We show that we can train a regression model on these data, using word embeddings and morphological features, that can predict these concreteness values with high accuracy. We evaluate the model on 7 publicly available datasets. Only for a few small subsets of these datasets prediction of concreteness values are found in the literature. Our results clearly outperform the reported results for these datasets.
Die Dunkle Triade besteht aus den Konstrukten Machiavellismus, Narzissmus sowie Psychopathie. Nachfolgend wird eine Untersuchung des Zusammenhangs zwischen den Konstrukten der Dunklen Triade und Studienerfolg berichtet. Studienerfolg wurde mittels Durchschnittsnote, Studiendauer, Kompetenzerwerb sowie Studienzufriedenheit operationalisiert und jeweils separat überprüft. Insgesamt wurden 98 Studierende der Hochschule Hannover befragt. Es konnten keine statistisch signifikanten Zusammenhänge zwischen den drei Konstrukten der Dunklen Triade und Durchschnittsnote sowie Studiendauer festgestellt werden. Ebenfalls konnten keine statistisch signifikanten Zusammenhänge zwischen Machiavellismus und Kompetenzerwerb sowie Studienzufriedenheit festgestellt werden. Auch für Narzissmus konnten keine statistisch signifikanten Zusammenhänge mit Kompetenzerwerb sowie Studienzufriedenheit festgestellt werden. Die Effekte dieser statistisch insignifikanten Ergebnisse sind in ihrer Höhe gering (r < 0,10). Als statistisch signifikant erwiesen sich die Zusammenhänge zwischen Psychopathie und Kompetenzerwerb (p = 0,01, r = -0,23) sowie zwischen Psychopathie und Studienzufriedenheit (p = 0,03, r = -0,20).
Lemmatization is a central task in many NLP applications. Despite this importance, the number of (freely) available and easy to use tools for German is very limited. To fill this gap, we developed a simple lemmatizer that can be trained on any lemmatized corpus. For a full form word the tagger tries to find the sequence of morphemes that is most likely to generate that word. From this sequence of tags we can easily derive the stem, the lemma and the part of speech (PoS) of the word. We show (i) that the quality of this approach is comparable to state of the art methods and (ii) that we can improve the results of Part-of-Speech (PoS) tagging when we include the morphological analysis of each word.
Der Tagungsband der Teaching Trends 2018 bietet allen Leser*innen spannende Einblicke in Präsenzhochschulen, die in geschickten Szenarien verschiedene digitale Medien für den Kompetenzerwerb ihrer Studierenden nutzen. In einer breiten Sicht auf die Digitalisierung beschäftigen sich die Tagungsbeiträge mit neuen Lernformaten wie Blended Learning und Inverted Classroom, deren aktuellen rechtlichen Rahmenbedingungen in DSGVO und Urheberrecht und technischen Grundlagen, z.B. in Augmented / Virtual Reality oder Audience Response. Darüber hinaus jedoch kommen übergreifende Strategien und Entwicklungskonzepte zu Wort, die die Hochschule in eine digitale Zukunft führen. In allen Bereichen berichteten die Vortragenden sowohl direkt aus ihrer Lehrpraxis als auch aus der begleitenden Forschung. Zur Abrundung der Tagung haben die Herausgeber*innen das einleitende Streitgespräch zur Bedeutung der digitalen Transformation für Universitäten, die Podiumsdiskussion zu Herausforderungen, die sich daraus für das Studium ergeben, sowie eine Keynote zur Architektur von Lernräumen zu Papier gebracht.
In this study, we investigated injection molded wood-polypropylene composites based on various wood sources and their decay resistance against white rot (Trametes versicolor) and brown rot (Coniophora puteana) in a laboratory test according to EN 15534-1:2014. The manufactured composites consisted of poplar (Populus spp.), willow (Salix spp.), European beech (Fagus sylvatica L.), Norway spruce (Picea abies (L.) H. Karst.), and a commercial wood source (Arbocel® C100), respectively. All formulations were compounded on a co-rotating twin screw extruder and subsequently injection molded to wood–PP specimens with a wood content of 60% or 70% by weight. It was found that the test procedure had a significant effect on the mechanical properties. Loss in mechanical properties was primarily caused by moisture and less by fungal decay. Moisture caused a loss in the modulus of rupture and modulus of elasticity of 34 to 45% and 29 to 73%, respectively. Mean mass and wood mass losses were up to a maximum of 3.7% and 5.3%, respectively. The high resistance against fungal decay was generally attributed to the encapsulation of wood by the polymer matrix caused by sample preparation, and enhanced by reduced moisture uptake during the preconditioning procedure. Notable differences with respect to the wood particle source and decay fungi were also observed. Structural characterization confirmed the decay pattern of the fungi such as void cavities close the surface and the deposition of calcium oxalates.
Radioisotope-guided sentinel lymph node dissection (sLND) has shown high diagnostic reliability in prostate (PCa) and other cancers. To overcome the limitations of the radioactive tracers, magnetometer-guided sLND using superparamagnetic iron oxide nanoparticles (SPIONs) has been successfully used in PCa. This prospective study (SentiMag Pro II, DRKS00007671) determined the diagnostic accuracy of magnetometer-guided sLND in intermediate- and high-risk PCa. Fifty intermediate- or high-risk PCa patients (prostate-specific antigen (PSA) >= 10 ng/mL and/or Gleason score >= 7; median PSA 10.8 ng/mL, IQR 7.4–19.2 ng/mL) were enrolled. After the intraprostatic SPIONs injection a day earlier, patients underwent magnetometer-guided sLND and extended lymph node dissection (eLND, followed by radical prostatectomy. SLNs were detected in in vivo and in ex vivo samples. Diagnostic accuracy of sLND was assessed using eLND as the reference. SLNs were detected in all patients (detection rate 100%), with 447 sentinel lymph nodes SLNs (median 9, IQR 6–12) being identified and 966 LNs (median 18, IQR 15–23) being removed. Thirty-six percent (18/50) of patients had LN metastases (median 2, IQR 1–3). Magnetometer-guided sLND had 100% sensitivity, 97.0% specificity, 94.4% positive predictive value, 100% negative predictive value, 0.0% false negative rate, and 3.0% additional diagnostic value (LN metastases only in SLNs outside the eLND template). In vivo, one positive SLN/LN-positive patient was missed, resulting in a sensitivity of 94.4%. In conclusion, this new magnetic sentinel procedure has high accuracy for nodal staging in intermediate- and high-risk PCa. The reliability of intraoperative SLN detection using this magnetometer system requires verification in further multicentric studies.