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Institute
- Fakultät III - Medien, Information und Design (432) (remove)
Obesity and excess adiposity account for approximately 20% of all cancer cases; however, biomarkers of risk remain to be elucidated. While fibroblast growth factor-2 (FGF2) is emerging as an attractive candidate biomarker for visceral adipose tissue mass, the role of circulating FGF2 in malignant transformation remains unknown. Moreover, functional assays for biomarker discovery are limited. We sought to determine if human serum could stimulate the 3D growth of a non-tumorigenic cell line. This type of anchorage-independent 3D growth in soft agar is a surrogate marker for acquired tumorigenicity of cell lines. We found that human serum from cancer-free men and women has the potential to stimulate growth in soft agar of non-tumorigenic epithelial JB6 P+ cells. We examined circulating levels of FGF2 in humans in malignant transformation in vitro in a pilot study of n = 33 men and women. Serum FGF2 levels were not associated with colony formation in epithelial cells (r = 0.05, p = 0.80); however, a fibroblast growth factor receptor-1 (FGFR1) selective inhibitor significantly blocked serum-stimulated transformation, suggesting that FGF2 activation of FGFR1 may be necessary, but not sufficient for the transforming effects of human serum. This pilot study indicates that the FGF2/FGFR1 axis plays a role in JB6 P+ malignant transformation and describes an assay to determine critical serum factors that have the potential to promote tumorigenesis.
Research information, i.e., data about research projects, organisations, researchers or research outputs such as publications or patents, is spread across the web, usually residing in institutional and personal web pages or in semi-open databases and information systems. While there exists a wealth of unstructured information, structured data is limited and often exposed following proprietary or less-established schemas and interfaces. Therefore, a holistic and consistent view on research information across organisational and national boundaries is not feasible. On the other hand, web crawling and information extraction techniques have matured throughout the last decade, allowing for automated approaches of harvesting, extracting and consolidating research information into a more coherent knowledge graph. In this work, we give an overview of the current state of the art in research information sharing on the web and present initial ideas towards a more holistic approach for boot-strapping research information from available web sources.
From an ethical perspective, clinical research involving humans is only acceptable if it involves the potential for benefit. Various characteristics can be applied to differentiate research benefit. Often benefit is categorized in direct or indirect benefit, whereby indirect benefit might be further differentiated in collective or benefit for the society, excluding or including the trial patient in the long term. Ethical guidelines, such as the Declaration of Helsinki in its latest version, do not precisely favor a particular type of benefit.
The practice, attitude, and knowledge of complementary and alternative medicine in Mumbai, India
(2020)
Background: In the recent times, there has been a resurging interest in the use of complementary and alternative medicine (CAM) in India. The present study was conducted to examine the prevalence of CAM use in Mumbai, the knowledge and attitude regarding CAM regarding its safety and efficacy and the reasons for the use of CAM.
Methods: A cross-sectional study was conducted among the general population of Mumbai and its adjoining regions during January-July 2020. 205 residents participated in the study and were asked to fill a pretested questionnaire. The collected data was analyzed using IBM SPSS version 23.
Results: Out of the 205 responses, 163 (79.51%) agreed to have used CAM at least once in their life. Of these, 108 (52.68%) respondents used Ayurveda and 105 (51.21%) used homeopathy. 60 (36.81%) of the respondents practicing CAM used it for common gastrointestinal (GIT)-related disorder with a 100% recovery rate, 125 (76.67%) for infectious diseases with a 93.6% recovery rate. 99 (60.74%) of the respondents preferring CAM for its safety profile, 68 (41.72%) believed that CAM is time tested and thus is efficacious. An integrative approach was suggested by 118 (57.56%) of all the respondents.
Conclusions: There is a disparity between the high prevalence in the use of CAM and its knowledge. However, a general consensus suggests that CAM is efficacious and is practiced for various indications.
The aim of the podcast Digitization of Medicine is to interest a broader audience and, in particular, young women, in research and work in the field of medical informatics. This article presents the usage figures and discusses their significance for further research on the success of science communication. By 24/02/2022, a total of 24,351 downloads had been made. There were slightly more female than male listeners, and they tended to be younger. Despite the importance podcast are gaining for science communication, little is known about the respective user group and further research is needed. In this context, this paper aims to help make the effectiveness of podcasts comparable.
Chronic kidney disease is one of the main causes of mortality worldwide. It affects more than 800 million patients globally, accounting for approximately 10% of the general population. The significant burden of the disease prompts healthcare systems to implement adequate preventive and therapeutic measures. This systematic review and meta-analysis aimed to provide a concise summary of the findings published in the existing body of research about the influence that mobile health technology has on the outcomes of patients with the disease. A comprehensive systematic literature review was conducted from inception until March 1st, 2023. This systematic review and meta-analysis included all clinical trials that compared the efficacy of mobile app-based educational programs to that of more conventional educational treatment for the patients. Eleven papers were included in the current analysis, representing 759 CKD patients. 381 patients were randomly assigned to use the mobile apps, while 378 individuals were assigned to the control group. The mean systolic blood pressure was considerably lower in the mobile app group (MD -4.86; 95%-9.60, -0.13; p=0.04). Meanwhile, the mean level of satisfaction among patients who used the mobile app was considerably greater (MD 0.75; 95% CI 0.03, 1.46; p=0.04). Additionally, the mean self-management scores in the mobile app groups were significantly higher (SMD 0.534; 95% CI 0.201, 0.867; p=0.002). Mobile health applications are potentially valuable interventions for patients. This technology improved the self-management of the disease, reducing the mean levels of systolic blood pressure with a high degree of patient satisfaction.
Within the HiGHmeducation consortium various online learning modules shall be developed by members of the consortium to address the increasing need for skilled professionals in a networked and digitalized healthcare system. Transferability of these modules to other locations is one main objective for the design of online learning modules. Thus, a didactical framework for online learning modules was developed. To ensure feasibility of the framework, the participating universities were analyzed concerning availability of e-learning support structures and infrastructures including learning management systems (LMS). The analysis especially focuses on the various LMS learning tools and their suitability for the framework. The framework is the basis for 12 HiGHmeducation online learning modules of which a part has firstly been conducted in winter 2019/20 and leads to a comparable structure of the modules.
Purpose: The calculation of aggregated composite measures is a widely used strategy to reduce the amount of data on hospital report cards. Therefore, this study aims to elicit and compare preferences of both patients as well as referring physicians regarding publicly available hospital quality information.
Methods: Based on systematic literature reviews as well as qualitative analysis, two discrete choice experiments (DCEs) were applied to elicit patients’ and referring physicians’ preferences. The DCEs were conducted using a fractional factorial design. Statistical data analysis was performed using multinomial logit models.
Results: Apart from five identical attributes, one specific attribute was identified for each study group, respectively. Overall, 322 patients (mean age 68.99) and 187 referring physicians (mean age 53.60) were included. Our models displayed significant coefficients for all attributes (p < 0.001 each). Among patients, “Postoperative complication rate” (20.6%; level range of 1.164) was rated highest, followed by “Mobility at hospital discharge” (19.9%; level range of 1.127), and ‘‘The number of cases treated” (18.5%; level range of 1.045). In contrast, referring physicians valued most the ‘‘One-year revision surgery rate’’ (30.4%; level range of 1.989), followed by “The number of cases treated” (21.0%; level range of 1.372), and “Postoperative complication rate” (17.2%; level range of 1.123).
Conclusion: We determined considerable differences between both study groups when calculating the relative value of publicly available hospital quality information. This may have an impact when calculating aggregated composite measures based on consumer-based weighting.
In der vorliegenden Masterarbeit geht es um die automatische Annotation von Bildern mithilfe der Kategoriesystematik der Wikipedia. Die Annotation soll anhand der Bildbeschriftungen und ihren Textreferenzen erfolgen. Hierbei wird für vorhandene Bilder eine passende Kategorie vorgeschlagen. Es handelt sich bei den Bildern um Abbildungen aus naturwissenschaftlichen Artikeln, die in Open Access Journals veröffentlicht wurden. Ziel der Arbeit ist es, ein konzeptionelles Verfahren zu erarbeiten, dieses anhand einer ausgewählten Anzahl von Bildern durchzuführen und zu evaluieren. Die Abbildungen sollen für weitere Forschungsarbeiten und für die Projekte der Wikimedia Foundation zur Verfügung stehen. Das Annotationsverfahren findet im Projekt NOA - Nachnutzung von Open Access Abbildungen Verwendung.
The reuse of scientific raw data is a key demand of Open Science. In the project NOA we foster reuse of scientific images by collecting and uploading them to Wikimedia Commons. In this paper we present a text-based annotation method that proposes Wikipedia categories for open access images. The assigned categories can be used for image retrieval or to upload images to Wikimedia Commons. The annotation basically consists of two phases: extracting salient keywords and mapping these keywords to categories. The results are evaluated on a small record of open access images that were manually annotated.
To learn a subject, the acquisition of the associated technical language is important.
Despite this widely accepted importance of learning the technical language, hardly any studies are published that describe the characteristics of most technical languages that students are supposed to learn. This might largely be due to the absence of specialized text corpora to study such languages at lexical, syntactical and textual level. In the present paper we describe a corpus of German physics text that can be used to study the language used in physics. A large and a small variant are compiled. The small version of the corpus consists of 5.3 Million words and is available on request.
Der Tagungsband der Teaching Trends 2018 bietet allen Leser*innen spannende Einblicke in Präsenzhochschulen, die in geschickten Szenarien verschiedene digitale Medien für den Kompetenzerwerb ihrer Studierenden nutzen. In einer breiten Sicht auf die Digitalisierung beschäftigen sich die Tagungsbeiträge mit neuen Lernformaten wie Blended Learning und Inverted Classroom, deren aktuellen rechtlichen Rahmenbedingungen in DSGVO und Urheberrecht und technischen Grundlagen, z.B. in Augmented / Virtual Reality oder Audience Response. Darüber hinaus jedoch kommen übergreifende Strategien und Entwicklungskonzepte zu Wort, die die Hochschule in eine digitale Zukunft führen. In allen Bereichen berichteten die Vortragenden sowohl direkt aus ihrer Lehrpraxis als auch aus der begleitenden Forschung. Zur Abrundung der Tagung haben die Herausgeber*innen das einleitende Streitgespräch zur Bedeutung der digitalen Transformation für Universitäten, die Podiumsdiskussion zu Herausforderungen, die sich daraus für das Studium ergeben, sowie eine Keynote zur Architektur von Lernräumen zu Papier gebracht.
Targeted panel sequencing in pediatric primary cardiomyopathy supports a critical role of TNNI3
(2019)
The underlying genetic mechanisms and early pathological events of children with primary cardiomyopathy (CMP) are insufficiently characterized. In this study, we aimed to characterize the mutational spectrum of primary CMP in a large cohort of patients ≤18 years referred to a tertiary center. Eighty unrelated index patients with pediatric primary CMP underwent genetic testing with a panel-based next-generation sequencing approach of 89 genes. At least one pathogenic or probably pathogenic variant was identified in 30/80 (38%) index patients. In all CMP subgroups, patients carried most frequently variants of interest in sarcomere genes suggesting them as a major contributor in pediatric primary CMP. In MYH7, MYBPC3, and TNNI3, we identified 18 pathogenic/probably pathogenic variants (MYH7 n = 7, MYBPC3 n = 6, TNNI3 n = 5, including one homozygous (TNNI3 c.24+2T>A) truncating variant. Protein and transcript level analysis on heart biopsies from individuals with homozygous mutation of TNNI3 revealed that the TNNI3 protein is absent and associated with upregulation of the fetal isoform TNNI1. The present study further supports the clinical importance of sarcomeric mutation-not only in adult-but also in pediatric primary CMP. TNNI3 is the third most important disease gene in this cohort and complete loss of TNNI3 leads to severe pediatric CMP.
This paper deals with new job profiles in libraries, mainly systems librarians (German: Systembibliothekare), IT librarians (German: IT-Bibliothekare) and data librarians (German: Datenbibliothekare). It investigates the vacancies and requirements of these positions in the German-speaking countries by analyzing one hundred and fifty published job advertisements of OpenBiblioJobs between 2012-2016. In addition, the distribution of positions, institutional bearers, different job titles as well as time limits, scope of work and remuneration of the positions are evaluated. The analysis of the remuneration in the public sector in Germany also provides information on demands for a bachelor's or master's degree.
The average annual increase in job vacancies between 2012 and 2016 is 14.19%, confirming the need and necessity of these professional library profiles.
The higher remuneration of the positions in data management, in comparison to the systems librarian, proves the prerequisite of the master's degree and thus indicates a desideratum due to missing or few master's degree courses. Accordingly, the range of bachelor's degree courses (or IT-oriented major areas of study with optional compulsory modules in existing bachelor's degree courses) for systems and IT librarians must be further expanded. An alternative could also be modular education programs for librarians and information scientists with professional experience, as it is already the case for music librarians.
Purpose. To identify stroke survivors with symptoms of poststroke depression and the extent of psychiatry needs and care they have received while on physiotherapy rehabilitation. Participants. Fifty stroke survivors (22 females and 28 males) at the outpatient unit of Physiotherapy Department, University of Nigeria Teaching Hospital, Enugu, who gave their informed consent, were randomly selected. Their age range and mean age were 26–66 years and 54.76 ± 8.79 years, respectively. Method. A multiple case study of 50 stroke survivors for symptoms of poststroke depression was done with Beck’s Depression Inventory, mini mental status examination tool, and Modified Motor Assessment Scale. The tests were performed independently by the participants except otherwise stated and scored on a scale of 0–6. Data were analyzed using -test for proportional significance and chi-square test for determining relationship between variables, at p < 0.05. Results. Twenty-one (42.0%) stroke survivors had symptoms of PSD, which was significantly dependent on duration of stroke ( = 21.680, df = 6, and p = 0.001), yet none of the participants had a psychiatry review. Conclusions. Symptoms of PSD may be common in cold compared to new cases of stroke and may need psychiatry care while on physiotherapy rehabilitation.
Background
The eResearch system “Prospective Monitoring and Management App (PIA)” allows researchers to implement questionnaires on any topic and to manage biosamples. Currently, we use PIA in the longitudinal study ZIFCO (Integrated DZIF Infection Cohort within the German National Cohort) in Hannover (Germany) to investigate e.g. associations of risk factors and infectious diseases. Our aim was to assess user acceptance and compliance to determine suitability of PIA for epidemiological research on transient infectious diseases.
Methods
ZIFCO participants used PIA to answer weekly questionnaires on health status and report spontaneous onset of symptoms. In case of symptoms of a respiratory infection, the app requested participants to self-sample a nasal swab for viral analysis. To assess user acceptance, we implemented the System Usability Scale (SUS) and fitted a linear regression model on the resulting score. For investigation of compliance with submitting the weekly health questionnaires, we used a logistic regression model with binomial response.
Results
We analyzed data of 313 participants (median age 52.5 years, 52.4% women). An average SUS of 72.0 reveals good acceptance of PIA. Participants with a higher technology readiness score at the beginning of study participation also reported higher user acceptance. Overall compliance with submitting the weekly health questionnaires showed a median of 55.7%. Being female, of younger age and being enrolled for a longer time decreased the odds to respond. However, women over 60 had a higher chance to respond than women under 60, while men under 40 had the highest chance to respond. Compliance with nasal swab self-sampling was 77.2%.
Discussion
Our findings show that PIA is suitable for the use in epidemiologic studies with regular short questionnaires. Still, we will focus on user engagement and gamification for the further development of PIA to help incentivize regular and long-term participation.
In the present paper we sketch an automated procedure to compare different versions of a contract. The contract texts used for this purpose are structurally differently composed PDF files that are converted into structured XML files by identifying and classifying text boxes. A classifier trained on manually annotated contracts achieves an accuracy of 87% on this task. We align contract versions and classify aligned text fragments into different similarity classes that enhance the manual comparison of changes in document versions. The main challenges are to deal with OCR errors and different layout of identical or similar texts. We demonstrate the procedure using some freely available contracts from the City of Hamburg written in German. The methods, however, are language agnostic and can be applied to other contracts as well.
Economic and political/governmental infrastructural factors are major contributors to the economic development/growth of all sectors of a country, such as in the area of healthcare systems and clinical research, including the pharmaceutical industry. But what is the interaction between economic, and political/governmental infrastructural factors and the development of healthcare systems, especially, the performance of the pharmaceutical industry? Information from selected articles of a literature search of PubMed and by using Google Advanced Search led to the generation of five categories of infrastructural factors, and were filled with data from 41 African Countries using the World Health Organization data repository. Median changes over time were given and tested by Wilcoxon signed-rank test and Friedman test, respectively. Analysis of factors related to availability of healthcare facilities showed that physicians and pharmacies were significant increased, with insignificantly decreased number of hospital beds. Healthcare Financing by the Government showed notable differences. Private health spending decreased significantly unlike Gross National Income. Analysis of infrastructural factors showed that stable supply of electricity and the associated use of the Internet improved significantly. The low level of data on the expansion of paved road networks suggests less developed medical services in remote rural areas. Healthcare systems in African countries improved over the last two decades, but differences between the individual countries still prevail and some of the countries cannot yet offer an attractive sales market for the products of pharmaceutical companies.
Die vorliegende Diplomarbeit beschäftigt sich mit dem Qualitätsmanagementverfahren der Arbeitsgemeinschaft der Kunst- und Museumsbibliotheken (AKMB). Dargestellt werden Hintergrund, Entwicklung und Praxis des Qualitätsmanagementverfahrens. Im Fokus stehen dabei die 83 Standards der AKMB. Die Arbeit verfolgt einen sehr praxisorientierten Ansatz, beleuchtet die Standards aus mehreren Perspektiven und liefert zahlreiche Empfehlungen, Erläuterungen, Checklisten und Hintergrundinformationen. Wer sich mit Qualitätsmanagement in Bibliotheken beschäftigen, auf ein Audit vorbereiten oder einen Einblick in die Entwicklung eines QM-Verfahrens erhalten möchte, findet in der vorliegenden Arbeit entsprechende Informationen.
Unternehmen befinden sich in einem Beziehungsgeflecht mit verschiedenen Stakeholdern, die differierende Ansprüche stellen und den Erfolg des Unternehmens stark beeinflussen. Unter diesen Gegebenheiten ist es von zentraler Bedeutung, gute Beziehungen zu den unterschiedlichen Gruppen und somit ein hohes Beziehungskapital aufzubauen. Eine Schlüsselfunktion kommt dabei der Kommunikation zu, da sie das Bindeglied zwischen Unternehmen und Stakeholdern darstellt.
Um mithilfe strategischen Kommunikationsmanagements die Beziehungen zu Stakeholdern zu stärken, müssen Unternehmen wissen, worauf überhaupt gute Beziehungen beruhen. Im Zentrum der Arbeit steht daher das soziale Kommunikations-Controlling von Unternehmen als Analyse- und Steuerungsfunktion und die Frage, aus welchen Faktoren sich das Beziehungskapital eines Unternehmens zusammensetzt. Im Gegensatz zum ökonomischen Kommunikations-Controlling fokussiert der soziale Ansatz nicht die ökonomische Ausrichtung der Kommunikation, sondern die Unternehmen-Stakeholder-Beziehungen.
Auf Basis des Beziehungskapital-Ansatzes von Szyszka und zentralen Reputationskonzepten wurden die Dimensionen und Indikatoren von Beziehungskapital hergeleitet. Eine quantitative Befragung einer breiten Öffentlichkeit diente anschließend der Prüfung des Entwurfs und der Identifikation möglicher weiterer Aspekte. Das Ergebnis stellt ein Modell dar, demnach Beziehungskapital aus folgenden acht Dimensionen besteht: die Produkte und Services, der unternehmerische Erfolg sowie die Kompetenz des Unternehmens als funktionale Komponenten, die soziale Verantwortung, die ökologische Verantwortung und die Verantwortung gegenüber den Mitarbeitern als soziale Komponenten sowie die Sympathie und Attraktivität des Unternehmens als affektive Komponenten. Die Dimensionen werden durch insgesamt 20 Indikatoren repräsentiert.
Das Modell lässt sich in den theoretischen Kontext des sozialen Kommunikations-Controllings einordnen und kann als Erweiterung des Beziehungskapital-Ansatzes hinzugezogen werden. In der Praxis liefert die Arbeit erste Hilfestellungen, um das Beziehungskapital eines Unternehmens bestimmen und darauf aufbauend ein strategisches Kommunikationsmanagement etablieren zu können.
Die vorliegende Bachelorarbeit befasst sich mit den Themen Usability digitaler Bibliotheksangebote, Nutzerorientierung und Zielgruppendefinition von Öffentlichen Bibliotheken. Die Bearbeiterin untersucht die Website der Stadtbibliothek Wolfsburg.
Die Zielgruppen der Stadtbibliothek werden unter Berücksichtigung der demografischen Struktur der Region definiert. Ebenso werden die Entstehungsgeschichte der Stadt beschrieben und wirtschaftliche Einflüsse aufgezeigt. Eine regionale Besonderheit ist die Abhängigkeit der Stadt Wolfsburg zum Volkswagen-Konzern, welche sich einmal mehr durch aktuelle Ereignisse wie den „Abgasskandal bei Volkswagen“ aus dem Jahr 2015 zeigt. Diese regionalspezifischen Aspekte haben insgesamt eine große Relevanz für die zielgruppenorientierte und nutzerfreundliche Gestaltung der Bibliothekswebsite. Allgemein gültige Usability-Standards werden hier an individuelle Faktoren angepasst.
Unter Berücksichtigung der Zielgruppendefinition und mithilfe einer Kombination der Usability-Methoden Personas-Verfahren, der Recherchedokumentation im Stil eines Thinking-Aloud-Protokolls und dem Abgleich mit ausgewählten Usability-Kriterien aus dem BibEval-Kriterienkatalog der HTW Chur untersucht die Bearbeiterin den Internetauftritt der Stadtbibliothek Wolfsburg im Praxisteil dieser Bachelorarbeit. Eine zusammenfassende Auswertung zeigt Stärken und Schwächen der Website auf und nennt darüber hinaus Verbesserungspotenziale.
Diese Arbeit ist interessant für Bibliothekare, die sich mit der Usability und Nutzerorientierung von digitalen Inhalten nach den spezifischen Zielgruppen einer Institution und ihrem Umfeld auseinander setzen möchten.
Spuren historischer Prozesse und ihrer mentalen Verarbeitung : Der Spielfilm "Dr. Holl" (1951)
(1993)
Wenngleich Arztfiguren in deutschen Spielfilmen immer wieder eine Rolle spielen, so wird von einer Arztfilmwelle doch erst in den fünfziger Jahren gesprochen. Ein Film, der für diese Welle häufig als Initialzündung genannt wird, ist der Film DR. HOLL aus dem Jahre 1951, ein Film, der in kurzer Zeit sechs Millionen deutsche Zuschauer erreichte. Der Filmerfolg trug dazu bei, dass der Regisseur Rolf Hansen einige Jahre "auf die Regie von Arztfilmen 'abonniert' war", und auch der männliche Hauptdarsteller Dieter Borsche musste sich weiterhin im Arztkittel bewähren. Diese Resonanz lässt den Film als besonders geeignet für eine Analyse erscheinen, die auf zeitgenössische Mentalitäten zielt. So soll im folgenden exemplarisch untersucht werden, wie sich zentrale Motive, Personenzeichnungen, anssatzweise auch die filmästhetische Realisierung vor dem zeithistorischen Hintergrund der frühen fünfziger Jahre ausnehmen - es wird hier also versucht, den Film als historische Quelle seiner Entstehungszeit zu lesen. Es folgt zunächst eine Inhaltsangabe von DR. HOLL.
Die vorliegende Bachelorarbeit stellt den Einsatz von Social Software beim Regionalfernsehsender „h1 – Fernsehen aus Hannover“ dar. Nach einem kurzen Einblick in die Grundlagen von Social Software folgt die Vorstellung des Senders. Hierbei wird vor allem der organisatorische Aufbau und die Kommunikation im Sender näher betrachtet. Anschließend wird dargestellt, welche Informationsmittel bei h1 durch den Einsatz von Social Software ersetzt wurden und wie sich dadurch die Kommunikation und das Informationsmanagement innerhalb des Unternehmens verbessert hat.
Social Scoring in China
(2023)
In den zurückliegenden Jahren hat eine Nachricht Schlagzeilen gemacht, die besonders in der westlichen Welt für Aufruhr gesorgt hat: Die Regierung der Volkrepublik China implementiere ein Sozialkreditsystem, das die Menschen in ihrem alltäglichen Verhalten bewerte und zu „Wohlverhalten" zwingen solle.
Diese Arbeit beschäftigt sich mit den Hintergründen des „Sozialkreditsystem", seiner Entstehung, Umsetzung und der Rezeption durch die chinesische Bevölkerung. Abschließend wird ein Vergleich mit ähnlichen Systemen in Deutschland versucht.
Die vorliegende Bachelor-Arbeit beschäftigt sich mit den Aspekten des Social Media Marketings. Dazu gehören die strategische Planung, das Monitoring sowie Richtlinien zum Umgang mit dem Medium und mit Krisen, die gemeinsam den Rahmen des Engagements im Social Web bilden. Die Verfasserin zeigt die grundlegenden Eigenschaften des Mediums Social Web und seiner Plattformen auf. Der Dialog und der Austausch sind zentraler Bestandteil von Social Media. Zudem behandelt die Arbeit die Notwendigkeit eines Social Media Engagements für Unternehmen und welche Voraussetzungen die Basis bilden. Einzelne Aspekte werden durch Beispiele aus der Praxis veranschaulicht sowie Thesen mit Statistiken und Aussagen von Experten belegt. Am Ende der Arbeit gibt die Verfasserin einen Ausblick auf die mögliche Wandlung von Social Media sowie die mobile Nutzung des Social Web und die daraus resultierenden Veränderungen.
Das Forschungscluster Smart Data Analytics stellt in dem vorliegenden Band seine Forschung aus den Jahren 2019 und 2020 vor. In der ersten Hälfte des Bandes geben 20 Kurzporträts von laufenden oder kürzlich abgeschlossenen Projekten einen Überblick über die Forschungsthemen im Cluster. Enthalten in den Kurzporträts ist eine vollständige, kommentierte Liste der wissenschaftlichen Veröffentlichungen aus den Jahren 2019 und 2020. In der zweiten Hälfte dieses Bandes geben vier längere Beiträge exemplarisch einen tieferen Einblick in die Forschung des Clusters und behandeln Themen wie Fehlererkennung in Datenbanken, Analyse und Visualisierung von Sicherheitsvorfällen in Netzwerken, Wissensmodellierung und Datenintegration in der Medizin, sowie die Frage ob ein Computerprogramm Urheber eines Kunstwerkes im Sinne des Urheberrechts sein kann.
Die vorliegende Bachelorarbeit beleuchtet die Sicherheitsaspekte von Webapplikationen, mit speziellem Fokus auf das CMS TYPO3. Im ersten Abschnitt werden die gesellschaftspolitischen Hintergründe von Internetkriminalität, sowie die allgemeine Rechtslage beschrieben. Der zweite Abschnitt erklärt die heutigen Angriffsmethoden, mit denen Webseiten attackiert werden. Im weiteren Verlauf der Arbeit untersucht der Autor anhand einer eigenen TYPO3 Installation, welche Möglichkeiten zur effektiven Optimierung der Sicherheit des CMS zur Verfügung stehen. Den Abschluß bilden eine Analyse der durchgeführten Maßnahmen, sowie die Aufstellung allgemeiner Richtlinien für vergleichbare Projekte.
We present a simple method to find topics in user reviews that accompany ratings for products or services. Standard topic analysis will perform sub-optimal on such data since the word distributions in the documents are not only determined by the topics but by the sentiment as well. We reduce the influence of the sentiment on the topic selection by adding two explicit topics, representing positive and negative sentiment. We evaluate the proposed method on a set of over 15,000 hospital reviews. We show that the proposed method, Latent Semantic Analysis with explicit word features, finds topics with a much smaller bias for sentiments than other similar methods.
Background: Fall events contribute significantly to mortality, morbidity and costs in our ageing population. In order to identify persons at risk and to target preventive measures, many scores and assessment tools have been developed. These often require expertise and are costly to implement. Recent research investigates the use of wearable inertial sensors to provide objective data on motion features which can be used to assess individual fall risk automatically. So far it is unknown how well this new method performs in comparison with conventional fall risk assessment tools. The aim of our research is to compare the predictive performance of our new sensor-based method with conventional and established methods, based on prospective data.
Methods: In a first study phase, 119 inpatients of a geriatric clinic took part in motion measurements using a wireless triaxial accelerometer during a Timed Up&Go (TUG) test and a 20 m walk. Furthermore, the St. Thomas Risk Assessment Tool in Falling Elderly Inpatients (STRATIFY) was performed, and the multidisciplinary geriatric care team estimated the patients’ fall risk. In a second follow-up phase of the study, 46 of the participants were interviewed after one year, including a fall and activity assessment. The predictive performances of the TUG, the STRATIFY and team scores are compared. Furthermore, two automatically induced logistic regression models based on conventional clinical and assessment data (CONV) as well as sensor data (SENSOR) are matched.
Results: Among the risk assessment scores, the geriatric team score (sensitivity 56%, specificity 80%) outperforms STRATIFY and TUG. The induced logistic regression models CONV and SENSOR achieve similar performance values (sensitivity 68%/58%, specificity 74%/78%, AUC 0.74/0.72, +LR 2.64/2.61). Both models are able to identify more persons at risk than the simple scores.
Conclusions: Sensor-based objective measurements of motion parameters in geriatric patients can be used to assess individual fall risk, and our prediction model’s performance matches that of a model based on conventional clinical and assessment data. Sensor-based measurements using a small wearable device may contribute significant information to conventional methods and are feasible in an unsupervised setting. More prospective research is needed to assess the cost-benefit relation of our approach.
Fall events and their severe consequences represent not only a threatening problem for the affected individual, but also cause a significant burden for health care systems. Our research work aims to elucidate some of the prospects and problems of current sensor-based fall risk assessment approaches. Selected results of a questionnaire-based survey given to experts during topical workshops at international conferences are presented. The majority of domain experts confirmed that fall risk assessment could potentially be valuable for the community and that prediction is deemed possible, though limited. We conclude with a discussion of practical issues concerning adequate outcome parameters for clinical studies and data sharing within the research community. All participants agreed that sensor-based fall risk assessment is a promising and valuable approach, but that more prospective clinical studies with clearly defined outcome measures are necessary.
Der Befund zum demografischen Wandel ist eindeutig: Die Bevölkerung in Deutschland altert und schrumpft. Dieser Prozess wird sich zunehmend auf den Arbeitsmarkt auswirken. Altersstrukturen in Unternehmen verschieben sich. Mit den absehbaren Verrentungswellen droht ein Verlust an Erfahrungswissen und Know-how, wenn Unternehmen diesem nicht mit Maßnahmen zum Wissenstransfer entgegentreten. Parallel verändert sich das Verhältnis von Alter, Ruhestand und Arbeit. Menschen im Rentenalter leben heute länger und gesünder, sie sind leistungsfähig und ihre Motivation zur nachberuflichen Aktivität steigt. Insbesondere ehemalige Fach- und Führungskräfte beteiligen sich trotz eines durch den Rentenbezug gesicherten Lebensunterhalts zunehmend als sogenannte Senior-Experten am Arbeitsmarkt oder engagieren sich freiwillig.
Vor dem Hintergrund dieser Entwicklung geht diese Masterarbeit der Frage nach, welche Bedeutung der Wissenstransfer beim Einsatz von Senior-Experten hat und untersucht Faktoren, die ihn beeinflussen. Die Arbeit stützt sich methodisch auf eine umfassende Literaturanalyse, einen typenbildenden Vergleich von Senior-Experten-Organisationen sowie auf eine qualitative Erhebung in Form von Leitfadeninterviews. Der theoretische Teil befasst sich mit drei Themenkomplexen: Alter und Arbeit, Wissensmanagement sowie Expertiseforschung. Im Mittelpunkt der Arbeit stehen relevante individuelle Einflussfaktoren, Begriffe, Institutionen und Methoden. Der empirische Teil steuert Erfahrungswerte aus der organisationalen Praxis bei.
Die Auswertung ergibt, dass Senior-Experten aufgrund ihrer Leistungsfähigkeit und Leistungsbereitschaft prädestiniert dafür sind, ihre Ressourcen zu nutzen, um ihr in vielen Berufsjahren erworbenes Wissen an die nächste Generation weiterzugeben. Der Wissenstransfer stellt das vorrangige Ziel beim Einsatz von Senior-Experten dar und nimmt folglich einen hohen Stellenwert ein. Das Bewusstsein für Faktoren, die den Wissenstransfer beeinflussen, kann hingegen noch geschärft werden. Wissenstransfermethoden mit einer personalisierten Herangehensweise können den Austausch von komplexem, schwer artikulierbarem Erfahrungs- und Expertenwissen fördern.
Background: Concerns about practice of self-medication (SM) world across are based on associated risks such as adverse reactions, disease masking, increased morbidity, wastage of resources and antibiotic resistance. SM is likely to differ between rural and urban areas of India. Systematically retrieved evidence on these differences are required in order to design targeted measures for improvement. Methods: We conducted a cross sectional study among the general population in urban (Matunga) and rural (Tala) areas of Maharashtra, India to explore SM practices and its associated factors. Face to face interviews were conducted using the validated study questionnaire. Data was analyzed by using descriptive and analytical statistical methods. Results: A total of 1523 inhabitants from 462 households were interviewed between [June/2015] and [August /2015], 778 (51%) of them in rural and 745 (49%) in urban areas. Overall self-medication prevalence was 29.1% (urban; 51.5%, rural; 7.7%, OR 12.7, CI 9.4-17.2) in the study participants. Participants having chronic disease (OR: 3.15, CI: 2.07-4.79) and from urban areas (OR:15.38, CI:8.49-27.85) were more likely to self-medicate. Self-medication practices were characterized by having old prescription (41.6%) as the main reason, fever (39.4%) as top indication and NSAIDs (Non-Steroidal Anti Inflammatory Agents) as the most self-medicated category of drugs (40.7%). Conclusions: The present study documented that the prevalence of self-medication is associated with place of residence, and health status of the study participants. Self-medication is still a major issue in western Maharashtra, India and is majorly an urban phenomenon. Status of implementation of existing regulations should be reconsidered.
Background: Self-medication, practiced globally is an important public health problem. Research studies have indicated inappropriate self‐medication results in adverse drug reactions, disease masking, antibiotic resistance and wastage of healthcare resources. The objectives of the study were to explore overall self-medication and antibiotic self-medication prevalence among students of university students in Karachi, Pakistan along with probable reasons, indications, and sources of advice for self-medication. Methods: A descriptive, cross-sectional, questionnaire-based study was carried out among students from university of Karachi, Pakistan during the time period of September to November 2016. Pretested questionnaire was distributed to 320 students, collected data was analyzed using IBM SPSS version 24. Results: From 320 students, 311 (83 male and 228 female) students participated in the study giving a response rate of 97%. Prevalence of self-medication was 66%. Belonging to higher monthly family income group was associated with likelihood of self-medication. Antibiotic self-medication prevalence was 39%. Lack of time (39%), and old prescription (35%) were the main reasons for self-medication. Pharmacy shop (75%) was the main source for self-medication. In case of antibiotics, 44% students changed the dosage of antibiotic and 50% students stopped antibiotics after the disappearance of the symptoms. Conclusions: Antibiotic self-medication (39%) and self-medication with other drugs among university students of Karachi is a worrisome problem. Our findings highlight the need for planning interventions to promote the judicious use of general medicines as well as that of antibiotics.
We compare the effect of different segmentation strategies for passage retrieval of user generated internet video. We consider retrieval of passages for rather abstract and complex queries that go beyond finding a certain object or constellation of objects in the visual channel. Hence the retrieval methods have to rely heavily on the recognized speech. Passage retrieval has mainly been studied to improve document retrieval and to enable question answering. In these domains best results were obtained using passages defined by the paragraph structure of the source documents or by using arbitrary overlapping passages. For the retrieval of relevant passages in a video no author defined paragraph structure is available. We compare retrieval results from 5 different types of segments: segments defined by shot boundaries, prosodic segments, fixed length segments, a sliding window and semantically coherent segments based on speech transcripts. We evaluated the methods on the corpus of the MediaEval 2011 Rich Speech Retrieval task. Our main conclusions are (1) that fixed length and coherent segments are clearly superior to segments based on speaker turns or shot boundaries; (2) that the retrieval results highly depend on the right choice for the segment length; and (3) that results using the segmentation into semantically coherent parts depend much less on the segment length. Especially, the quality of fixed length and sliding window segmentation drops fast when the segment length increases, while quality of the semantically coherent segments is much more stable. Thus, if coherent segments are defined, longer segments can be used and consequently fewer segments have to be considered at retrieval time.
Der Bedeutungszuwachs von Online-Medien hat eine gesellschaftliche Debatte über mögliche Folgen dieser Entwicklung ausgelöst. Weit verbreitet ist zum Beispiel die Wahrnehmung, dass Online-Medien maßgeblich beeinflussen, wie insbesondere jüngere Menschen politische Prozesse sehen und bewerten. Vor dem Hintergrund theoretischer Ansätze wie dem Influence-of-Presumed-Media-Influence-Approach wurde untersucht, welche kommunikationspolitischen Maßnahmen von der Bevölkerung als Reaktion auf solche Wahrnehmungen als angemessen eingeschätzt werden. Hierzu wurde im Kontext der Landtagswahl in Nordrhein-Westfalen 2012 eine Online-Befragung durchgeführt (n = 485). Die Befunde zeigen, dass die Wahrnehmung starker politischer Online-Einflüsse auf jüngere Menschen vor allem zu einer gesteigerten Akzeptanz von Aufklärung und Erziehung führt, weniger aber zu einer gesteigerten Akzeptanz restriktiver Maßnahmen zur Einflussbeschränkung.
Diese Bachelorarbeit untersucht den Einfluss von Fitness-Influencer*innen auf Instagram auf die Körperzufriedenheit der Rezipierenden. Sie untersucht die Auswirkungen von Fitness-Influencer*innen und dessen Internetauftritt auf die Zufriedenheit mit dem eigenen Körper der Rezipierenden unter Einbeziehung sozialer Vergleichsprozesse. Um empirische Befunde liefern zu können, wurde eine standardisierte Online-Befragung durchgeführt.
In den letzten Jahren wurden verstärkt neue Forschungsinformationssysteme (FIS) geplant, aufgebaut und in Betrieb genommen. Da diese IT-gestützten Informationssysteme eine Vielzahl an Forschungsinformationen beinhalten sowie verschiedenen Zielen dienen können, bietet eine Sammlungsrichtlinie die Möglichkeit, die Entscheidungen auf inhaltlicher Ebene verbindlich und transparent darzustellen. Derartige Richtlinien existieren zum Beispiel bereits für Sammlungen in Bibliotheken und Museen. Die Bachelorarbeit zieht Parallelen zu diesen Bereichen und beschreibt deren Ziele und Inhalte.
In einem praxisbezogenen Teil wurde die Sammlungsrichtlinie für das Informationssystem Göttingen Research Online (GRO) erstellt. Die Vorgehensweise, Hindernisse und Erfahrungen werden zusammenfassend wiedergegeben. Ergänzt werden die Erkenntnisse durch eine Befragung unter deutschen Hochschulen und Forschungseinrichtungen.
Abschließend ist eine Empfehlung für eine FIS-Sammlungsrichtlinie entstanden, die Hinweise, Bestandteile und Best Practices enthält und somit anderen Institutionen als Leitfaden dienen kann.
The most important attribute for which we all aspire as human beings is good health because it enables us to undertake different forms of activities of daily living. The emergence of scientific knowledge in Western societies has enabled us to explore and define several parameters of “health” by drawing boundaries around factors that are known to impact the achievement of good health. For example, the World Health Organization defined health by taking physical and psychological factors into consideration.
Roads to Health in Developing Countries: Understanding the Intersection of Culture and Healing
(2017)
Background:
The most important attribute to which all human beings aspire is good health because it enables us to undertake different forms of activities of daily living. The emergence of scientific knowledge in Western societies has enabled scientists to explore and define several parameters of health by drawing boundaries around factors that are known to influence the attainment of good health. For example, the World Health Organization defined health by taking physical and psychological factors into consideration. Their definition of health also included a caveat that says, “not merely the absence of sickness.”
This definition has guided scientists and health care providers in the Western world in the development of health care programs in non-Western societies.
Objective:
However, ethnomedical beliefs about the cause(s) of illness have given rise to alternative theories of health, sickness, and treatment approaches in the developing world. Thus, there is another side to the story.
Method:
Much of the population in developing countries lives in rural settings where the knowledge of health, sickness, and care has evolved over centuries of practice and experience. The definition of health in these settings tends to orient toward cultural beliefs, traditional practices, and social relationships. Invariably, whereas biomedicine is the dominant medical system in Western societies, traditional medicine — or ethno-medicine — is often the first port of call for patients in developing countries.
Results:
The 2 medical systems represent, and are influenced by, the cultural environment in which they exist. On one hand, biomedicine is very effective in the treatment of objective, measurable disease conditions. On the other hand, ethnomedicine is effective in the management of illness conditions or the experience of disease states. Nevertheless, an attempt to supplant 1 system of care with another from a different cultural environment could pose enormous challenges in non-Western societies.
Conclusion:
In general, we, as human beings, are guided in our health care decisions by past experiences, family and friends, social networks, cultural beliefs, customs, tradition, professional knowledge, and intuition. No medical system has been shown to address all of these elements; hence, the need for collaboration, acceptance, and partnership between all systems of care in cultural communities. In developing countries, the roads to health are incomplete without an examination of the intersection of culture and healing. Perhaps mutual exclusiveness rather inclusiveness of these 2 dominant health systems is the greatest obstacle to health in developing countries.
Research question: In order to reduce fan aggression surrounding rivalry games, team sport organizations often try to placate fans by downplaying the importance of the game (e.g. ‘the derby is not a war’). Drawing on the intergroup conflict literature, this research derives dual identity statements and examines their effectiveness in reducing fan aggressiveness compared to the managerial practice of downplaying rivalry.
Research methods: Three field experimental studies (one face-to-face survey and two online surveys) tested the hypotheses. Established rivalries in the German soccer league Bundesliga served as the empirical setting of the studies. The data were analyzed using ANCOVA and linear regression analyses.
Results and findings: Dual identity statements reduce fan aggressiveness compared to both downplay statements and a no-statement control condition, independent of team identification and trait aggression. Importantly, the managerial practice of downplaying rivalry appears to be counterproductive. It produces even higher levels of fan aggressiveness than making no statement, an effect caused by psychological reactance.
Implications: Sport organizations should not alienate their fan base by attempting to play down the importance of rivalry, which is an integral part of fan identity. Instead, they should strengthen the supporters’ unique identity (as fans of a particular team) while at the same time facilitating identification with the rival at a superordinate level (e.g. as joint fans of a region).
Rezension zu der Doppelausstellung "Zeitenwende 1400" des Dommuseums Hildesheim und des Landesmuseums Hannover. Während die Ausstellung im Hildesheimer Dommuseum ausgehend von der Stadt und dem Hochstift Hildesheim sowie der weiteren Region eine kulturhistorische Gesamtschau der Zeit um 1400 präsentiert, stellt die Ausstellung im Landesmuseum Hannover die Goldene Tafel aus der Benediktinerabteikirche St. Michaelis in Lüneburg, ein Flügelaltarretabel aus den ersten Jahrzehnten des 15. Jahrhunderts, als herausragendes Kunstwerk des Spätmittelalters in den Mittelpunkt.
Rezension zu:
Rösch, Hermann et al.: Bibliotheken und Informationsgesellschaft in Deutschland : eine Einführung / Hermann Rösch, Jürgen Seefeldt, Konrad Umlauf ; unter Mitarbeit von Albert Bilo und Eric W. Steinhauer ; mitbegründet von Engelbert Plassmann. – 3., neukonzipierte und aktualisierte Auflage. – Wiesbaden: Harrassowitz Verlag, 2019. – XIII, 329 Seiten. – ISBN 9783447066204 : EUR 39.80 (auch als EBook verfügbar)
Medical devices are health care products distinguished from drugs for regulatory purposes in most countries based on mechanism of action. Unlike drugs, medical devices operate via physical or mechanical means and are not dependent on metabolism to accomplish their primary intended effect. Developing new medical devices requires clinical investigations and approval process goes through similar process like drugs. Medical device approvals in the period of 2010 to 2014 were searched from USFDA website. Disease burden data in the similar period was searched from centers for disease control and prevention website. Collected data was analyzed to know number of approved devices, top therapy areas, and mechanism of action of these devices. Out of a total of 200 medical devices approvals in the time period of 2010 to 2014, maximum number of devices (51; 25.5%) were approved in the year 2011, cardiovascular (78; 39%) was the top therapy area. Highest number (180; 90%) of approved medical devices belonged to the category III and maximum number (73; 36.5%) of approved medical devices had ―mechanical‖ mechanism of action. The top 3 causes of deaths in USA during 2010 to 2014 were heart disease, cancer and followed by respiratory infection. There was a match between the top diseases and the medical device approvals for top 2 diseases in USA i.e. heart disease, and cancer. With respect to respiratory infections and ailments which was the 3rd leading cause of death only one device was approved out of 200 approvals in total.
Background: The mission of the pharmacy profession is to improve public health through ensuring safe, effective, and appropriate use of medications. Population health management (PHP) is a process wherein opportunities are identified to improve the quality of health care delivered and thereby, promote better health outcomes for patients.
Rationale: As concept of PHP is extremely important in today’s context, it is helpful to integrate data related to pharmacist in population health management practices. Authors conducted a systematic review of the literature on role of pharmacist in population health management practices. Method: We conducted a systematic review of the literature on literature on role of pharmacist in population health management practices by searching, PubMed Medline database using the following combination of keywords – pharmacist, population health. Truncation was used to ensure retrieval of all possible variations of search terms. The search was limited to articles published between 1st January 2015 and 31st December 2019, human studies and English language.
Results: Initial search resulted in a total of 281 studies, title abstract review to remove irrelevant studies resulted in 256 studies. Yearly trend showed that number of publications are decreasing. Highest number of publications were from Europe (47; 18%) and 29 publications (11%) discussed role of pharmacist in population health management of subjects in the age group of 10 to 20 years. Twenty five publications mentioned health management was done in the community settings. Advice on the lifestyle was mentioned in 242 (96%) and 10 (4%) publications offered advice about drugs during the health management. Pharmacists played important roles in population health management for e.g. as care provider in exploring the challenges faced in clinics for management of Type 2 DM. Pharmacists played an important role in increasing the quality of life of patients.
Discussion: Population health management concept has evolved steadily over the past few decades and is now contributing to the ‘patient care journey’ at all stages. There were 24 (9%) publications from India. Specially designed and implemented Pharm D program would play a major role in Indian health care system in future. This will give an opportunity to pharmacists to work more prominently in Indian health care system.
Conclusion: Authors are of the opinion that this is the first review encompassing the topic of pharmacist and population health management in the global context. It is clear that there is a global trend of moving towards involvement of pharmacist in healthcare management. This enables pharmacists to assume an expanded role and at same time it necessitates reforms in pharmacy education and practice.