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Blickpunkt Existenzgründung
(2003)
Blickpunkt Design und Medien
(2003)
research
(2002)
[Geld]
(2002)
Ingenieurwissenschaften
(2002)
Qualität
(2001)
Blickpunkt China
(2001)
Interdisziplinarität
(2000)
Studierende
(1999)
Forschung
(1998)
Internationalität
(1998)
Blickpunkt Zukunft
(1997)
Für die Studiengang-Auswahl existiert eine Reihe i. d. R. Fragebogen-gestützter Online-Studiengangfinder. Eine Analyse zeigte Optimierungspotenziale: Studienangebote sind meist auf ein Bundesland oder eine Hochschule beschränkt oder, allgemein beschrieben, die individuelle Studiengang-Auswahl ist nur mit Unschärfen möglich. Letzteres wirkt sich z. B. bei Bindestrich-Studiengängen (z. B. Wirtschaftsingenieurwesen) aus, die je nach Hochschule inhaltlich variieren können. Hier setzt das Portal an. Ziele sind: Bereitstellung der in der Sprachwelt Studieninteressierter gehaltenen Fragebögen, Möglichkeit für Hochschulen/Einrichtungen, Studiengänge bereitzustellen.
Background: Given both the increase of nursing home residents forecast and challenges of current interprofessional interactions, we developed and tested measures to improve collaboration and communication between nurses and general practitioners (GPs) in this setting. Our multicentre study has been funded by the German Federal Ministry of Education and Research (FK 01GY1124).
Methods: The measures were developed iteratively in a continuous process, which is the focus of this article. In part 1 “exploration of the situation”, interviews were conducted with GPs, nurses, nursing home residents and their relatives focusing on interprofessional interactions and medical care. They were analysed qualitatively. Based on these results, in part 2 “development of measures to improve collaboration”, ideas for improvement were developed in nine focus groups with GPs and nurses. These ideas were revisited in a final expert workshop. We analysed the focus groups and expert workshop using mind mapping methods, and finally drew up the compilation of measures. In an exploratory pilot study "study part 3" four nursing homes chose the measures they wanted to adopt. These were tested for three months. Feasibility and acceptance of the measures were evaluated via guideline interviews with the stakeholders which were analysed by content analyses.
Results: Six measures were generated: meetings to establish common goals, main contact person, standardised pro re nata medication, introduction of name badges, improved availability of nurse/GP and standardised scheduling/ procedure for nursing home visits. In the pilot study, the measures were implemented in four nursing homes. GPs and nurses reviewed five measures as feasible and acceptable, only the designation of a “main contact person” was not considered as an improvement.
Conclusions: Six measures to improve collaboration and communication could be compiled in a multistep qualitative process respecting the perspectives of involved stakeholders. Five of the six measures were positively assessed in an exploratory pilot study. They could easily be transferred into the daily routine of other nursing homes, as no special models have to exist in advance. Impact of the measures on patient oriented outcomes should be examined in further research.
Trial registration: Not applicable.
Delphi is a frequently used research method in the information systems (IS) field. The last fifteen years have seen many variants of the Delphi Method proposed and used in IS research. However, these variants do not seem to be properly derived; while all variants share certain characteristics, their reasoning for differentiation inconsistently varies. It seems that researchers tend to create “new” Delphi Method variants, although the underlying modification of the Delphi Method is, in fact, minor. This leads to a heterogeneity of Delphi Method variants and undermines scientific rigor when using Delphi. The study addresses this deficit and (1) identifies different variants of Delphi and determines their characteristics, (2) critically reflects to what extent a clear distinction between these variants exists, (3) shows the clearly distinguishable Delphi Method variants and their characteristics, (4) develops a proposed taxonomy of Delphi Method variants, and (5) evaluates and applies this taxonomy. The proposed taxonomy helps clearly differentiate Delphi Method variants and enhances methodological rigor when using the Delphi Method.
Forschungsgegenstand der Bachelorarbeit ist der politisch gefärbte und direktiv gestaltete Aushandlungs- und Planungsprozess für die Bebauung eines zentralen innerstädtischen Platzes in Hannover. Entlang der Leitfrage, wie der demokratische Anspruch nach Bürger*innenbeteiligung in Stadtentwicklungsprozessen aus den Konzepten in die Umsetzung gelangt und welche Bevölkerungsgruppen in eben diesen Prozessen Ein- und Ausschlüsse erfahren, welche sie reproduzieren, finden eine mehrschichtige Verlaufsuntersuchung und eine Rückbindung in mögliche Betätigungsfelder der Sozialen Arbeit statt.
Der Bachelorarbeit vorangegangen ist ein Praxisseminar zur Gemeinwesenarbeit und Öffentlichkeit, in welchem eine Feldanalyse stattfand. Anhand von angekündigten leitfadengestützen Expert*inneninterviews und qualitativen Interviews auf dem besagten Platz kristallisierte sich die offensichtliche Unkenntnis der Passant*innen über die Bebauungspläne heraus: Ein von offizieller Seite betontes Beteiligungsverfahren zur Neugestaltung ist den Nutzer*innen vielfach nicht bekannt gewesen.
Methodisch wurde anhand des Governancekonzepts nach Baum (2012), Klöti (2016) und Walk (2011) und der „unternehmerischen Stadt“ nach Harvey (1989) die Einbindung von Sozialer Arbeit in Stadtentwicklungsprozesse analysiert. Ausgewertet wurden die Dokumentationen der Innenstadtforen im Rahmen des Policykonzepts „Hannover City 2020+“. Festzuhalten gilt, dass die zentrale Aufgabe der Sozialen Arbeit in diesem Zusammenhang benannt werden kann als die Thematisierung von sozialem Ausschluss (Anhorn & Bettinger 2005) und den hohen Voraussetzungen für den Zugang zu Beteiligung und Mitgestaltung des öffentlichen Raumes. Gezeigt wird, dass das erste Beteiligungsverfahren einer Scheinbeteiligung (Arnstein 1969) zur Legitimation von Ergebnissen aus Behörden- und Expert*innenenrunden diente; viele der eigentlichen Nutzer*innen des Platzes wurden nicht erreicht und beteiligt, da die Strukturen des Partizipationsangebotes zu hochschwellig und exklusiv angelegt waren. Es wird deutlich, dass die öffentlichen Verfahren bestenfalls der Information gedient haben.
Diese Arbeit ist ein Plädoyer für eine planungsbezogene Soziale Arbeit (Drilling & Oehler 2013), welche sich räumlich-reflexiv und aktiv in die Gestaltung und Planung von Stadt einbringt, anstatt nur im Nachhinein daraus entstandene Konflikte und Probleme wie Ausschluss und Verdrängung von Randgruppen zu bearbeiten. Im bisherigen Prozess hat Soziale Arbeit die Aufgabe, sich kritisch im Interesse der marginalisierten Nutzer*innengruppen einzubringen und advokatisch tätig zu sein, bzw. darüber hinaus diese dabei zu unterstützen sich wirkungsvoll einzubringen, nicht wahrgenommen. In dem kommenden Verfahren 2018 bietet sich die Chance einer inkludierenderen Beteiligung durch Methoden der Bürger*innenbeteiligung wie bspw. der Zukunftswerkstatt (Dienel 2011: 208ff) direkt auf dem Platz, in denen gegebenenfalls mehr Menschen zu Wort kommen als bei den bisherigen Verfahren.
Objectives:
The aim was to identify theoretically expected as well as actually reported benefits from drug development and the importance of individual patient benefits compared to the collective benefits to society in general.
Background:
Ethical guidelines require that clinical research involving humans offer the potential for benefit. A number of characteristics can be applied to define research benefit. Often benefit is categorized as being either direct or indirect. Indirect benefits can involve collective benefits for society rather than any benefits to the trial patient or subject. The purpose of this review was to examine which potential individual and societal benefits were mentioned as being expected in publications from government experts and which were mentioned in publications describing completed drug development trial results.
Methods:
Literature on research benefit was first identified by searching the PubMed database using several combinations of the key words benefit and clinical research. The search was limited to articles published in English. A Google search with the same combinations of key words but without any language limitation was then performed. Additionally, the reference lists of promising articles were screened for further thematically related articles. Finally, a narrative review was performed of relevant English- and German-language articles published between 1996 and 2016 to identify which of several potential benefits were either theoretically expected or which were mentioned in publications on clinical drug development trial results.
Results:
The principal benefits from drug development discussed included 2 main types of benefit, namely individual benefits for the patients and collective benefits for society. Twenty-one of an overall total of 26 articles discussing theoretically expected benefits focused on individual patient benefits, whereas 17 out of 26 articles mentioned collective benefits to society. In these publications, the most commonly mentioned theoretically expected individual patient benefit was the chance to receive up-to-date care (38.1%). A general increase in knowledge about health care, treatments, or drugs (70.6%) was the most commonly mentioned theoretically expected benefit for society. In contrast, all 13 publications reporting actual benefits of clinical drug development trials focused on personal benefits and only 1 of these publications also mentioned a societal benefit. The most commonly mentioned individual benefit was an increased quality of life (53.9%), whereas the only mentioned collective benefit to society was a general gain of knowledge (100.0%).
Conclusions:
Both theoretically expected and actually reported benefits in the majority of the included publications emphasized the importance of individual patient benefits from drug development rather than the collective benefits to society in general. The authors of these publications emphasized the right of each individual patient or subject to look for and expect some personal benefit from participating in a clinical trial rather than considering societal benefit as a top priority. From an ethical point of view, the benefits each individual patient receives from his or her participation in a clinical trial might also be seen as a societal benefit, especially when the drug or device tested, if approved for marketing, would eventually be made available for other similar patients from the country in which the clinical trial was conducted.
Roads to Health in Developing Countries: Understanding the Intersection of Culture and Healing
(2017)
Background:
The most important attribute to which all human beings aspire is good health because it enables us to undertake different forms of activities of daily living. The emergence of scientific knowledge in Western societies has enabled scientists to explore and define several parameters of health by drawing boundaries around factors that are known to influence the attainment of good health. For example, the World Health Organization defined health by taking physical and psychological factors into consideration. Their definition of health also included a caveat that says, “not merely the absence of sickness.”
This definition has guided scientists and health care providers in the Western world in the development of health care programs in non-Western societies.
Objective:
However, ethnomedical beliefs about the cause(s) of illness have given rise to alternative theories of health, sickness, and treatment approaches in the developing world. Thus, there is another side to the story.
Method:
Much of the population in developing countries lives in rural settings where the knowledge of health, sickness, and care has evolved over centuries of practice and experience. The definition of health in these settings tends to orient toward cultural beliefs, traditional practices, and social relationships. Invariably, whereas biomedicine is the dominant medical system in Western societies, traditional medicine — or ethno-medicine — is often the first port of call for patients in developing countries.
Results:
The 2 medical systems represent, and are influenced by, the cultural environment in which they exist. On one hand, biomedicine is very effective in the treatment of objective, measurable disease conditions. On the other hand, ethnomedicine is effective in the management of illness conditions or the experience of disease states. Nevertheless, an attempt to supplant 1 system of care with another from a different cultural environment could pose enormous challenges in non-Western societies.
Conclusion:
In general, we, as human beings, are guided in our health care decisions by past experiences, family and friends, social networks, cultural beliefs, customs, tradition, professional knowledge, and intuition. No medical system has been shown to address all of these elements; hence, the need for collaboration, acceptance, and partnership between all systems of care in cultural communities. In developing countries, the roads to health are incomplete without an examination of the intersection of culture and healing. Perhaps mutual exclusiveness rather inclusiveness of these 2 dominant health systems is the greatest obstacle to health in developing countries.
One of the main concerns of this publication is to furnish a more rational basis for discussing bioplastics and use fact-based arguments in the public discourse. Furthermore, “Biopolymers – facts and statistics” aims to provide specific, qualified answers easily and quickly for decision-makers in particular from public administration and the industrial sector. Therefore, this publication is made up like a set of rules and standards and largely foregoes textual detail. It offers extensive market-relevant and technical facts presented in graphs and charts, which means that the information is much easier to grasp. The reader can expect comparative market figures for various materials, regions, applications, process routes, agricultural land use, water use or resource consumption, production capacities, geographic distribution, etc.
The development of Artificial Intelligence (AI) has profound implications for improving human and computational productivity in the future. However, it also is an existential risk to human life because it could exceed human capabilities. As such, information about the technology, the direction of the development and its purpose is important. This can be achieved through openness and transparency of processes. Indeed, companies hold property rights over AI and monopolies of software, data and experts. As a countermovement to leading AI companies, the “Open AI Movement” has evolved to push open-source AI research and products, to empower users, and to bridge the digital divide through participation and access. In this thesis, the implications of the declaration of AI as a commons have been analyzed through interviews with AI experts in the United States. The legal placement of AI is controversial but it could be seen as a basic human right. Other findings are that this field is very competitive and that the best approach is to collaboratively develop software that adds additional value on the edge of the commons.
Objective: To evaluate the impact of different dissemination channels on the awareness and usage of hospital performance reports among referring physicians, as well as the usefulness of such reports from the referring physicians’ perspective.
Data sources/Study setting: Primary data collected from a survey with 277 referring physicians (response rate = 26.2%) in Nuremberg, Germany (03–06/2016).
Study design: Cluster-randomised controlled trial at the practice level. Physician practices were randomly assigned to one of two conditions: (1) physicians in the control arm could become aware of the performance reports via mass media channels (Mass Media, npr MM=132, nph MM=147); (2) physicians in the intervention arm also received a printed version of the report via mail (Mass and Special Media, npr MSM=117; nph MSM=130). <br> Principal findings: Overall, 68% of respondents recalled hospital performance reports and 21% used them for referral decisions. Physicians from the Mass and Special Media group were more likely to be aware of the performance reports (OR 4.16; 95% CI 2.16–8.00, p < .001) but not more likely to be influenced when referring patients into hospitals (OR 1.73; 95% CI 0.72–4.12, p > .05). On a 1 (very good) to 6 (insufficient) scale, the usefulness of the performance reports was rated 3.67 (±1.40). Aggregated presentation formats were rated more helpful than detailed hospital quality information.
Conclusions: Hospital quality reports have limited impact on referral practices. To increase the latter, concerns raised by referring physicians must be given more weight. Those principally refer to the underlying data, the design of the reports, and the lack of important information.
Background: Physician-rating websites (PRWs) may lead to quality improvements in case they enable and establish a peer-to-peer communication between patients and physicians. Yet, we know little about whether and how physicians respond on the Web to patient ratings.
Objective: The objective of this study was to describe trends in physicians’ Web-based responses to patient ratings over time, to identify what physician characteristics influence Web-based responses, and to examine the topics physicians are likely to respond to.
Methods: We analyzed physician responses to more than 1 million patient ratings displayed on the German PRW, jameda, from 2010 to 2015. Quantitative analysis contained chi-square analyses and the Mann-Whitney U test. Quantitative content techniques were applied to determine the topics physicians respond to based on a randomly selected sample of 600 Web-based ratings and corresponding physician responses.
Results: Overall, physicians responded to 1.58% (16,640/1,052,347) of all Web-based ratings, with an increasing trend over time from 0.70% (157/22,355) in 2010 to 1.88% (6377/339,919) in 2015. Web-based ratings that were responded to had significantly worse rating results than ratings that were not responded to (2.15 vs 1.74, P<.001). Physicians who respond on the Web to patient ratings differ significantly from nonresponders regarding several characteristics such as gender and patient recommendation results (P<.001 each). Regarding scaled-survey rating elements, physicians were most likely to respond to the waiting time within the practice (19.4%, 99/509) and the time spent with the patient (18.3%, 110/600). Almost one-third of topics in narrative comments were answered by the physicians (30.66%, 382/1246).
Conclusions: So far, only a minority of physicians have taken the chance to respond on the Web to patient ratings. This is likely because of (1) the low awareness of PRWs among physicians, (2) the fact that only a few PRWs enable physicians to respond on the Web to patient ratings, and (3) the lack of an active moderator to establish peer-to-peer communication. PRW providers should foster more frequent communication between the patient and the physician and encourage physicians to respond on the Web to patient ratings. Further research is needed to learn more about the motivation of physicians to respond or not respond to Web-based patient ratings.
Das Konzept soll eine Grundlage zur Bereitstellung von Open Educational Resources (OER) für Studierende der Hochschule Hannover sein. Entstanden ist dieses auf Grundlage eines Studierendenprojektes (Bereitstellung von OER auf einer geeigneten Plattform) des Studiengangs "Informationsmanagement – berufsbegleitend". Aufgrund der kurzen Projektzeit, Schwierigkeiten bei der Auswahl einer geeigneten Plattform und einer problematischen Inhaltsrecherche konnte keine langfristige Lösung zur Bereitstellung von OER gefunden werden. Dieses Konzept soll die Erfahrungen der Projektgruppe zusammenfassen und an die Bibliothek der Hochschule Hannover sowie das E-Learning-Center weitergegeben werden. Ergänzt wird das Konzept durch allgemeine Informationen zu OER, Vorschläge für die Bereitstellung und Ideen für das weitere Vorgehen.
Demografieorientiertes Personalmanagement in kleinen und mittleren wissenschaftlichen Bibliotheken
(2017)
Der demografische Wandel stellt für das Personalmanagement eine Herausforderung dar, mit der sich auch Bibliotheken auseinandersetzen müssen. Die vorliegende Arbeit setzt sich mit der Frage auseinander, welche Maßnahmen des Personalmanagements kleine und mittlere wissenschaftliche Bibliotheken anwenden und inwiefern sie damit auf den demografischen Wandel vorbereitet sind. Der erste Teil der Arbeit umfasst die theoretischen Grundlagen. Dafür werden zunächst die zentralen Begriffe demografischer Wandel, Personalmanagement sowie Personalentwicklung definiert. Anschließend werden Handlungsfelder sowie deren Bedeutung für ein demografieorientiertes Personalmanagement dargestellt. Diese umfassen die Altersstrukturanalyse, die Personalgewinnung, die Personalbindung, die Personalentwicklung, die Gesundheitsförderung und das Gesundheitsmanagement sowie den Wissenstransfer. Sie beinhalten außerdem auch Beispiele von Maßnahmen aus größeren wissenschaftlichen sowie öffentlichen Bibliotheken. Die aus einer Befragung gewonnenen Erkenntnisse über die Maßnahmen des Personalmanagements in kleinen und mittleren wissenschaftlichen Bibliotheken werden im zweiten Teil der Arbeit beschrieben. Abschließend werden anhand der theoretischen Grundlagen sowie der gewonnenen Erkenntnisse Handlungsempfehlungen für die Zielgruppe der kleinen und mittleren wissenschaftlichen Bibliotheken gegeben.
Editorial for the 17th European Networked Knowledge Organization Systems Workshop (NKOS 2017)
(2017)
Knowledge Organization Systems (KOS), in the form of classification systems, thesauri, lexical databases, ontologies, and taxonomies, play a crucial role in digital information management and applications generally. Carrying semantics in a well-controlled and documented way, Knowledge Organization Systems serve a variety of important functions: tools for representation and indexing of information and documents, knowledge-based support to information searchers, semantic road maps to domains and disciplines, communication tool by providing conceptual framework, and conceptual basis for knowledge based systems, e.g. automated classification systems. New networked KOS (NKOS) services and applications are emerging, and we have reached a stage where many KOS standards exist and the integration of linked services is no longer just a future scenario. This editorial describes the workshop outline and overview of presented papers at the 17th European Networked Knowledge Organization Systems Workshop (NKOS 2017) which was held during the TPDL 2017 Conference in Thessaloniki, Greece.
The amount of papers published yearly increases since decades. Libraries need to make these resources accessible and available with classification being an important aspect and part of this process. This paper analyzes prerequisites and possibilities of automatic classification of medical literature. We explain the selection, preprocessing and analysis of data consisting of catalogue datasets from the library of the Hanover Medical School, Lower Saxony, Germany. In the present study, 19,348 documents, represented by notations of library classification systems such as e.g. the Dewey Decimal Classification (DDC), were classified into 514 different classes from the National Library of Medicine (NLM) classification system. The algorithm used was k-nearest-neighbours (kNN). A correct classification rate of 55.7% could be achieved. To the best of our knowledge, this is not only the first research conducted towards the use of the NLM classification in automatic classification but also the first approach that exclusively considers already assigned notations from other
classification systems for this purpose.
For indexing archived documents the Dutch Parliament uses a specialized thesaurus. For good results for full text retrieval and automatic classification it turns out to be important to add more synonyms to the existing thesaurus terms. In the present work we investigate the possibilities to find synonyms for terms of the parliaments thesaurus automatically. We propose to use distributional similarity (DS). In an experiment with pairs of synonyms and non-synonyms we train and test a classifier using distributional similarity and string similarity. Using ten-fold cross validation we were able to classify 75% of the pairs of a set of 6000 word pairs correctly.
Die Digitalisierung birgt sowohl für den Unternehmer, als auch für den Kunden diverse Vorteile. Als Instrument zur Veranschaulichung dieser Vorteile dienen vor allem Service-Apps, welche bereits von großen Unternehmen beispielsweise zur Produktnachverfolgung etabliert wurden. Das Mittelstand 4.0 – Kompetenzzentrum Hannover legt den Fokus auf kleine und mittelständische Produktionsbetriebe und vermittelt das Potenzial der Digitalisierung im Rahmen von Industrie 4.0. Dies geschieht anhand einer Produktionslinie personalisierter Kugelschreiber und einer zu Demonstrationszwecken entwickelten App für mobile Endgeräte. Konzeptionierung, Entwicklung und Umsetzung dieser App werden genauestens aufgeführt und erläutert. Die App wurde unter dem Betriebssystem Android entwickelt und gliedert sich in sieben Phasen, beginnend mit der Anforderungsanalyse bis hin zur Veröffentlichung im Google Play Store. Während der Unternehmer die Möglichkeit geboten bekommt, Rückschlüsse als Entscheidungshilfe zur effizienteren Gestaltung der Produktion zu nutzen, ist der Kunde in der Lage, seine Aufträge echtzeitnah in der Produktion nachzuverfolgen und gegebenenfalls Änderungen vorzunehmen.
Das Erreichen eines höheren Bildungsstands gegenüber dem Bildungsstand der Eltern ist häufig mit einer Bewältigung von herkunftsbedingten Widerständen verbunden. Neben leistungsbezogenen Anforderungen an Bildungsaufsteiger sind häufig auch psychosoziale Anforderungen zu bewältigen, die durch einen Aufstieg in eine höhere soziale Schicht entstehen. Nachfolgend wird untersucht, ob Resilienz ein Einflussfaktor auf Bildungsaufstieg ist oder nicht. Es wurde eine Datenerhebung an 157 Studierenden der Hochschule Hannover durchgeführt. Zwischen den 77 Bildungsaufsteigern und den 80 Nichtbildungsaufsteigern dieser Stichprobe wurde kein signifikanter Unterschied hinsichtlich Resilienz gefunden. In einer Vorstudie wurde mit der Resilienzskala RS-29 die Resilienzskala RS-25 (Schumacher et al., 2005) weiterentwickelt und empirisch überprüft. Eine Datenerhebung der RS-29 an 416 Studierenden der Hochschule Hannover bestätigte drei vermutete Faktoren tendenziell.
Die Studie gibt einen Überblick über Energiemanagementfunktionen und deren Integration in Automatisierungssysteme. Sie besteht aus den folgenden Teilen:
1.) Bestandsaufnahme und Marktübersicht von Energiemanagementsystemen, insbesondere von den an der Studie beteiligten Firmen und zwei weitere Produkte als Referenz.
2.) Anwenderinterviews mit Anwendern aus verschiedenen Schlüsselindustrien der Prozess- und Fertigungsautomatisierung zur Evaluierung künftiger Anforderungen und Erwartungen an ein Energiemanagement insbesondere auch im Hinblick auf die Integration in Automatisierungssysteme.
3.) Bedeutung des Energiemanagements in der Zukunft und daraus abzuleitende Maßnahmen.
A systematic review of the literature on survey questionnaires to assess self-medication practices
(2017)
Self-medication is of great public health importance as it often bypasses regulatory mechanisms to assure quality of health care. Nevertheless there are no established standards on how to assess self-medication. We therefore intended to systematically retrieve questionnaires and survey tools used to capture self-medication, with the aim to identify the scope of information investigated in this context and commonalities between the tools. We conducted a systematic review of the literature on questionnaires used for self-medication assessment by searching PubMed and Web of Science databases using the combinations of following keywords; self-medication, self-prescription, non-prescription, questionnaire. Truncation was used to ensure retrieval of all possible variations of search terms. The search was limited to articles published between 1st January 2000 and 31st December 2015, human studies and English language. Duplicate and irrelevant studies were excluded from the final review. A total of 158 studies were included in the review. Studies were from diverse geographical locations, most of the studies were from Nigeria 16 (10.1%) followed by India 10 (6.3%) and Iran 8 (5%). Forty-three studies (27.2%) focused on antibiotic self-medication. Majority of the studies (106; 67%) were done with adult populations. The components addressed by the questionnaires covered: reasons for self-medications in 147 (93%) studies, purchasing source in 136 (86%) studies, medical conditions to be treated in 153 (96.8%) studies, adverse events in 67 (42.4%) studies, use of prescribing information in 24 (15.1%) studies and antibiotic resistance awareness in 20 (46.5%) antibiotic studies. For 74 (46.8%) studies, survey questionnaires were self-administered and most studies (57; 36%) were done at homes of respondents. Thirty-seven (23.4%) studies did not report any recall period for self-medication practices. Study response rates varied from 17.9% to 100%, and while validity of the study questionnaire was reported for 100 (63.3%) studies, 15 (9.5%) studies reported reliability test of the study questionnaire. There is a large variety of questionnaires being used for investigating self-medication practices making comparability and meta-analyses very difficult. It is desirable to have a basic set of standardized survey questions on this topic to make available for future research groups in this field.
This document concerns IT security in production facilities. It is intended for small and medium-sized enterprises that are looking for a simple procedural model for ensuring IT security in production areas.
In order to raise readers’ awareness of IT security in production facilities, security incidents are presented in section 2. It is clear that cyber attacks on production facilities in this day and age are not random, but are instead based on a targeted process.
An overview of the most important standards and recommendations on the topic of “IT security in production” then follows in section 3.
Section 4 develops a concept for setting up an IT security system for small and medium-sized enterprises (SMEs) on the basis of a ten-point plan. The focus is not only on technical measures, but also in particular on the most frequently neglected organizational measures.
Section 5 then describes the outlook for future requirements and solutions in the context of Industry 4.0.
Dieses Dokument befasst sich mit der IT-Sicherheit von Produktionsanlagen. Es richtet sich an kleine und mittlere Unternehmen, welche auf der Suche nach einem einfachen Vorgehensmodell für die Sicherstellung der IT-Sicherheit im Produktionsbereich sind.
Um Leser für die Notwendigkeit der IT-Sicherheit von Produktionsanlagen zu sensibilisieren, werden in Kapitel 2 Sicherheitsvorfälle dargestellt. Es zeigt sich, dass Cyber-Angriffe auf Produktionsanlagen heute kein Zufall mehr sind, sondern auf einem gezielten Vorgehen beruhen.
Danach folgt in Kapitel 3 ein Überblick über die wichtigsten Normen und Empfehlungen zum Themenfeld „IT-Sicherheit in der Produktion“.
Kapitel 4 entwickelt an Hand eines Zehn-Punkte-Plans ein Konzept für den Aufbau eines IT-Sicherheitssystems für kleine und mittlere Unternehmen (KMU). Dabei liegt der Schwerpunkt nicht nur auf den technischen, sondern insbesondere auch auf den häufig vernachlässigten organisatorischen Maßnahmen.
Abschließend gibt Kapitel 5 einen Ausblick auf künftige Anforderungen und Lösungen im Kontext von Industrie 4.0
Antimicrobial resistance in livestock is a matter of general concern. To develop hygiene measures and methods for resistance prevention and control, epidemiological studies on a population level are needed to detect factors associated with antimicrobial resistance in livestock holdings. In general, regression models are used to describe these relationships between environmental factors and resistance outcome. Besides the study design, the correlation structures of the different outcomes of antibiotic resistance and structural zero measurements on the resistance outcome as well as on the exposure side are challenges for the epidemiological model building process. The use of appropriate regression models that acknowledge these complexities is essential to assure valid epidemiological interpretations. The aims of this paper are (i) to explain the model building process comparing several competing models for count data (negative binomial model, quasi-Poisson model, zero-inflated model, and hurdle model) and (ii) to compare these models using data from a cross-sectional study on antibiotic resistance in animal husbandry. These goals are essential to evaluate which model is most suitable to identify potential prevention measures. The dataset used as an example in our analyses was generated initially to study the prevalence and associated factors for the appearance of cefotaxime-resistant Escherichia coli in 48 German fattening pig farms. For each farm, the outcome was the count of samples with resistant bacteria. There was almost no overdispersion and only moderate evidence of excess zeros in the data. Our analyses show that it is essential to evaluate regression models in studies analyzing the relationship between environmental factors and antibiotic resistances in livestock. After model comparison based on evaluation of model predictions, Akaike information criterion, and Pearson residuals, here the hurdle model was judged to be the most appropriate model.
Background: Fall events contribute significantly to mortality, morbidity and costs in our ageing population. In order to identify persons at risk and to target preventive measures, many scores and assessment tools have been developed. These often require expertise and are costly to implement. Recent research investigates the use of wearable inertial sensors to provide objective data on motion features which can be used to assess individual fall risk automatically. So far it is unknown how well this new method performs in comparison with conventional fall risk assessment tools. The aim of our research is to compare the predictive performance of our new sensor-based method with conventional and established methods, based on prospective data.
Methods: In a first study phase, 119 inpatients of a geriatric clinic took part in motion measurements using a wireless triaxial accelerometer during a Timed Up&Go (TUG) test and a 20 m walk. Furthermore, the St. Thomas Risk Assessment Tool in Falling Elderly Inpatients (STRATIFY) was performed, and the multidisciplinary geriatric care team estimated the patients’ fall risk. In a second follow-up phase of the study, 46 of the participants were interviewed after one year, including a fall and activity assessment. The predictive performances of the TUG, the STRATIFY and team scores are compared. Furthermore, two automatically induced logistic regression models based on conventional clinical and assessment data (CONV) as well as sensor data (SENSOR) are matched.
Results: Among the risk assessment scores, the geriatric team score (sensitivity 56%, specificity 80%) outperforms STRATIFY and TUG. The induced logistic regression models CONV and SENSOR achieve similar performance values (sensitivity 68%/58%, specificity 74%/78%, AUC 0.74/0.72, +LR 2.64/2.61). Both models are able to identify more persons at risk than the simple scores.
Conclusions: Sensor-based objective measurements of motion parameters in geriatric patients can be used to assess individual fall risk, and our prediction model’s performance matches that of a model based on conventional clinical and assessment data. Sensor-based measurements using a small wearable device may contribute significant information to conventional methods and are feasible in an unsupervised setting. More prospective research is needed to assess the cost-benefit relation of our approach.
Background: In many research areas it is necessary to find differences between treatment groups with several variables. For example, studies of microarray data seek to find a significant difference in location parameters from zero or one for ratios thereof for each variable. However, in some studies a significant deviation of the difference in locations from zero (or 1 in terms of the ratio) is biologically meaningless. A relevant difference or ratio is sought in such cases.
Results: This article addresses the use of relevance-shifted tests on ratios for a multivariate parallel two-sample group design. Two empirical procedures are proposed which embed the relevanceshifted test on ratios. As both procedures test a hypothesis for each variable, the resulting multiple testing problem has to be considered. Hence, the procedures include a multiplicity correction. Both procedures are extensions of available procedures for point null hypotheses achieving exact control of the familywise error rate. Whereas the shift of the null hypothesis alone would give straight-forward solutions, the problems that are the reason for the empirical considerations discussed here arise by the fact that the shift is considered in both directions and the whole parameter space in between these two limits has to be accepted as null hypothesis.
Conclusion: The first algorithm to be discussed uses a permutation algorithm, and is appropriate for designs with a moderately large number of observations. However, many experiments have limited sample sizes. Then the second procedure might be more appropriate, where multiplicity is corrected according to a concept of data-driven order of hypotheses.
The present investigation was conducted to investigate the in-vitro activity of ethanolic extract of roots of Centaurea behens by using DPPH radical scavenging activity, nitric oxide radical scavenging activity, hydrogen peroxide radical scavenging activity, hydroxyl radical. Result suggests that the extract possess significant antioxidant activity as compared to the standard ascorbic acid and thus further in vivo investigation is required to evaluate the medicinal significance of the extract which can be used for assessing the possible therapeutic importance of the drug.
Wearable sensors in healthcare and sensor-enhanced health information systems: all our tomorrows?
(2012)
Wearable sensor systems which allow for remote or self-monitoring of health-related parameters are regarded as one means to alleviate the consequences of demographic change. This paper aims to summarize current research in wearable sensors as well as in sensor-enhanced health information systems. Wearable sensor technologies are already advanced in terms of their technical capabilities and are frequently used for cardio-vascular monitoring. Epidemiologic predictions suggest that neuro-psychiatric diseases will have a growing impact on our health systems and thus should be addressed more intensively. Two current project examples demonstrate the benefit of wearable sensor technologies: long-term, objective measurement under daily-life, unsupervised conditions. Finally, up-to-date approaches for the implementation of sensor-enhanced health information systems are outlined. Wearable sensors are an integral part of future pervasive, ubiquitous and person-centered health
care delivery. Future challenges include their integration into sensor-enhanced health information systems and sound evaluation studies involving measures of workload reduction and costs.
Mining geriatric assessment data for in-patient fall prediction models and high-risk subgroups
(2012)
Background: Hospital in-patient falls constitute a prominent problem in terms of costs and consequences. Geriatric institutions are most often affected, and common screening tools cannot predict in-patient falls consistently. Our objectives are to derive comprehensible fall risk classification models from a large data set of geriatric in-patients’ assessment data and to evaluate their predictive performance (aim#1), and to identify high-risk subgroups from the data (aim#2).
Methods: A data set of n = 5,176 single in-patient episodes covering 1.5 years of admissions to a geriatric hospital were extracted from the hospital’s data base and matched with fall incident reports (n = 493). A classification tree model was induced using the C4.5 algorithm as well as a logistic regression model, and their predictive performance was evaluated. Furthermore, high-risk subgroups were identified from extracted classification rules with a support of more than 100 instances.
Results: The classification tree model showed an overall classification accuracy of 66%, with a sensitivity of 55.4%, a specificity of 67.1%, positive and negative predictive values of 15% resp. 93.5%. Five high-risk groups were identified, defined by high age, low Barthel index, cognitive impairment, multi-medication and co-morbidity.
Conclusions: Our results show that a little more than half of the fallers may be identified correctly by our model, but the positive predictive value is too low to be applicable. Non-fallers, on the other hand, may be sorted out with the model quite well. The high-risk subgroups and the risk factors identified (age, low ADL score, cognitive impairment, institutionalization, polypharmacy and co-morbidity) reflect domain knowledge and may be used to screen certain subgroups of patients with a high risk of falling. Classification models derived from a large data set using data mining methods can compete with current dedicated fall risk screening tools, yet lack diagnostic precision. High-risk subgroups may be identified automatically from existing geriatric assessment data, especially when combined with domain knowledge in a hybrid classification model. Further work is necessary to validate our approach in a controlled prospective setting.
Fall events and their severe consequences represent not only a threatening problem for the affected individual, but also cause a significant burden for health care systems. Our research work aims to elucidate some of the prospects and problems of current sensor-based fall risk assessment approaches. Selected results of a questionnaire-based survey given to experts during topical workshops at international conferences are presented. The majority of domain experts confirmed that fall risk assessment could potentially be valuable for the community and that prediction is deemed possible, though limited. We conclude with a discussion of practical issues concerning adequate outcome parameters for clinical studies and data sharing within the research community. All participants agreed that sensor-based fall risk assessment is a promising and valuable approach, but that more prospective clinical studies with clearly defined outcome measures are necessary.
Complications may occur after a liver transplantation, therefore proper monitoring and care in the post-operation phase plays a very important role. Sometimes, monitoring and care for patients from abroad is difficult due to a variety of reasons, e.g., different care facilities. The objective of our research for this paper is to design, implement and evaluate a home monitoring and decision support infrastructure for international children who underwent liver transplant operation. A point-of-care device and the PedsQL questionnaire were used in patients’ home environment for measuring the blood parameters and assessing quality of life. By using a tablet PC and a specially developed software, the measured results were able to be transmitted to the health care providers via internet. So far, the developed infrastructure has been evaluated with four international patients/families transferring 38 records of blood test. The evaluation showed that the home monitoring and decision support infrastructure is technically feasible and is able to give timely alarm in case of abnormal situation as well as may increase parent’s feeling of safety for their children.
Der zielorientierte Umgang mit Wissen bildet eine zentrale Herausforderung für Unternehmen und deren Mitarbeiter. Deren Kompetenzentwicklung ist für die Unternehmen unter dem Aspekt der Wettbewerbsfähigkeit ein lohnendes Ziel. Diese Arbeit stellt ein Werkzeug zur Messung von Kompetenzen im Persönlichen Wissensmanagement vor. Auf einer Literaturstudie basierend wurde ein Kompetenzkatalog erstellt und mit Hilfe einer Befragung von Fachleuten aus dem Bereichen Informations- und Wissensmanagement validiert. Dieser Kompetenzkatalog findet Eingang in einen Referenzrahmen für Kompetenzen für Persönliches Wissensmanagement. Zur Bestimmung der Niveaustufen Experte, Könner und Kenner im Persönlichen Wissensmanagement wurde ein Messwerkzeug erarbeitet und anhand von zwei Gruppen auf Gültigkeit überprüft. Die eine Gruppe bestand aus Mitarbeitern Exzellenter Wissensorganisationen, die andere aus interessierten Mitarbeitern aus nicht-explizit wissensorientierten Unternehmen. Es konnte nachgewiesen werden, dass beide Gruppen in acht Einzelkompetenzen signifikante Unterschiede besaßen. Auch für weitere Kompetenzen konnten Messdimensionen aus den Rückmeldungen der Umfrage hergeleitet werden. In einigen Fällen allerdings konnten die Niveaustufen Könner und Kenner nicht unterschieden werden.
Digitale 3D-Modelle der Architektur – z.B. Modelle von Gebäuden, Inneneinrichtungsgegenständen und Bauteilen – haben innerhalb der letzten fünf Jahrzehnte sowohl die analogen, auf Papier basierenden Zeichnungen als auch die physischen Modelle aus ihrer planungs-, ausführungs- und dokumentationsunterstützenden Rolle verdrängt. Als Herausforderungen bei der Integration von 3D-Modellen in digitale Bibliotheken und Archive sind zunächst die meist nur rudimentäre Annotation mit Metadaten seitens der Autoren und die nur implizit in den Modellen vorhandenen
Informationen zu nennen. Aus diesen Defiziten resultiert ein aktuell starkes Interesse an inhaltsbasierter Erschließung durch vernetzte Nutzergruppen oder durch automatisierte Verfahren, die z.B. aufgrund von Form- oder Strukturmerkmalen eine automatische Kategorisierung von 3D-Modellen anhand gegebener Schemata ermöglichen. Die teilweise automatische Erkennung von objektinhärenter Semantik vergrößert die Menge an diskreten und semantisch unterscheidbaren Einheiten. Darüber hinaus sind digitale 3D-Modelle zumeist hierarchisch aufgebaut; sie enthalten weitere komplexe Modelle, die wiederum in sich geschachtelt sein können und in einzelnen Fällen einen eigenständigen Nachweis als 3D-Modell wünschenswert machen. 3D-Modelle als Content im World Wide Web können sowohl untereinander als auch mit anderen textuellen wie nichttextuellen Objekten verknüpft werden, also Teil von aggregierten Dokumenten sein. Eine weitere Notwendigkeit ist die Vernetzung mit inhaltlich relevanten Ereignissen, Orten, Begriffen, Personen oder realen Objekten sowie die explizite Beschreibung der Relationen zwischen dem Modell selbst und diesen Entitäten seines spezifischen Kontextes. Die Aggregationen bzw. der Modellkontext sowie die inhärenten Entitäten erfordern Instrumente der Organisation, um dem Benutzer bei der Suche nach Informationen einen Mehrwert zu bieten, insbesondere dann, wenn textbasiert nach Informationen zum Modell und zu dessen Kontext gesucht wird. In der vorliegenden Arbeit wird ein Metadatenmodell zur gezielten Strukturierung von Information entwickelt, welche aus 3D-Architekturmodellen gewonnen wird. Mittels dieser Strukturierung kann das Modell mit weiterer Information vernetzt werden. Die Anwendung etablierter Ontologien sowie der Einsatz von URIs machen die Informationen nicht nur explizit, sondern beinhalten auch eine semantische Information über die Relation selbst, sodass eine Interoperabilität zu anderen verfügbaren Daten im Sinne der Grundprinzipien des Linked-Data-Ansatzes gewährleistet wird. Diese Herangehensweise hat im Gegensatz zu einem Ansatz, der Metadaten als Records auffasst, das Potenzial, Relationen zu jeglichen modellrelevanten Entitäten im Suchraum herzustellen und zugleich diese Relationen für weitere wissensbildende Prozesse verfügbar zu machen.
Background: After kidney transplantation, immunosuppressive therapy causes impaired cellular immune defense leading to an increased risk of viral complications. Trough level monitoring of immunosuppressants is insufficient to estimate the individual intensity of immunosuppression. We have already shown that virus-specific T cells (Tvis) correlate with control of virus replication as well as with the intensity of immunosuppression. The multicentre IVIST01-trial should prove that additional steering of immunosuppressive and antiviral therapy by Tvis levels leads to better graft function by avoidance of over-immunosuppression (for example, viral infections) and drug toxicity (for example, nephrotoxicity).
Methods/design: The IVIST-trial starts 4 weeks after transplantation. Sixty-four pediatric kidney recipients are randomized either to a non-intervention group that is only treated conservatively or to an intervention group with additional monitoring by Tvis. The randomization is stratified by centre and cytomegalovirus (CMV) prophylaxis. In both groups the immunosuppressive medication (cyclosporine A and everolimus) is adopted in the same target range of trough levels. In the non-intervention group the immunosuppressive therapy (cyclosporine A and everolimus) is only steered by classical trough level monitoring and the antiviral therapy of a CMV infection is performed according to a standard protocol. In contrast, in the intervention group the dose of immunosuppressants is individually adopted according to Tvis levels as a direct measure of the intensity of immunosuppression in addition to classical trough level monitoring. In case of CMV infection or reactivation the antiviral management is based on the individual CMV-specific immune defense assessed by the CMV-Tvis level. Primary endpoint of the study is the glomerular filtration rate 2 years after transplantation; secondary endpoints are the number and severity of viral infections and the incidence of side effects of immunosuppressive and antiviral drugs.
Discussion: This IVIST01-trial will answer the question whether the new concept of steering immunosuppressive and antiviral therapy by Tvis levels leads to better future graft function. In terms of an effect-related drug monitoring, the study design aims to realize a personalization of immunosuppressive and antiviral management after transplantation. Based on the IVIST01-trial, immunomonitoring by Tvis might be incorporated into routine care after kidney transplantation.
Research information, i.e., data about research projects, organisations, researchers or research outputs such as publications or patents, is spread across the web, usually residing in institutional and personal web pages or in semi-open databases and information systems. While there exists a wealth of unstructured information, structured data is limited and often exposed following proprietary or less-established schemas and interfaces. Therefore, a holistic and consistent view on research information across organisational and national boundaries is not feasible. On the other hand, web crawling and information extraction techniques have matured throughout the last decade, allowing for automated approaches of harvesting, extracting and consolidating research information into a more coherent knowledge graph. In this work, we give an overview of the current state of the art in research information sharing on the web and present initial ideas towards a more holistic approach for boot-strapping research information from available web sources.
Clinical scores and motion-capturing gait analysis are today’s gold standard for outcome measurement after knee arthroplasty, although they are criticized for bias and their ability to reflect patients’ actual quality of life has been questioned. In this context, mobile gait analysis systems have been introduced to overcome some of these limitations. This study used a previously developed mobile gait analysis system comprising three inertial sensor units to evaluate daily activities and sports. The sensors were taped to the lumbosacral junction and the thigh and shank of the affected limb. The annotated raw data was evaluated using our validated proprietary software. Six patients undergoing knee arthroplasty were examined the day before and 12 months after surgery. All patients reported a satisfactory outcome, although four patients still had limitations in their desired activities. In this context, feasible running speed demonstrated a good correlation with reported impairments in sports-related activities. Notably, knee flexion angle while descending stairs and the ability to stop abruptly when running exhibited good correlation with the clinical stability and proprioception of the knee. Moreover, fatigue effects were displayed in some patients. The introduced system appears to be suitable for outcome measurement after knee arthroplasty and has the potential to overcome some of the limitations of stationary gait labs while gathering additional meaningful parameters regarding the force limits of the knee.
Background: Maintenance of metal homeostasis is crucial in bacterial pathogenicity as metal starvation is the most important mechanism in the nutritional immunity strategy of host cells. Thus, pathogenic bacteria have evolved sensitive metal scavenging systems to overcome this particular host defence mechanism. The ruminant pathogen Mycobacterium avium ssp. paratuberculosis (MAP) displays a unique gut tropism and causes a chronic progressive intestinal inflammation. MAP possesses eight conserved lineage specific large sequence polymorphisms (LSP), which distinguish MAP from its ancestral M. avium ssp. hominissuis or other M. avium subspecies. LSP14 and LSP15 harbour many genes proposed to be involved in metal homeostasis and have been suggested to substitute for a MAP specific, impaired mycobactin synthesis.
Results: In the present study, we found that a LSP14 located putative IrtAB-like iron transporter encoded by mptABC was induced by zinc but not by iron starvation. Heterologous reporter gene assays with the lacZ gene under control of the mptABC promoter in M. smegmatis (MSMEG) and in a MSMEGΔfurB deletion mutant revealed a zinc dependent, metalloregulator FurB mediated expression of mptABC via a conserved mycobacterial FurB recognition site. Deep sequencing of RNA from MAP cultures treated with the zinc chelator TPEN revealed that 70 genes responded to zinc limitation. Remarkably, 45 of these genes were located on a large genomic island of approximately 90 kb which harboured LSP14 and LSP15. Thirty-five of these genes were predicted to be controlled by FurB, due to the presence of putative binding sites. This clustering of zinc responsive genes was exclusively found in MAP and not in other mycobacteria.
Conclusions: Our data revealed a particular genomic signature for MAP given by a unique zinc specific locus, thereby suggesting an exceptional relevance of zinc for the metabolism of MAP. MAP seems to be well adapted to maintain zinc homeostasis which might contribute to the peculiarity of MAP pathogenicity.