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Der Bericht über die Mitgliederversammlung gliedert sich in vier Teile: Einen kurzen Bericht über die formalen Anteile der Versammlung (1), die kurze Vorstellung der mit dem Cora-Baltussen-Förderpreis ausgezeichneten Abschlussarbeiten (2), eine Paraphrase des Vortrags von Armin Nassehi (3) sowie eine kritisch-kommentierende Diskussion des Fishbowls über Führungskräfte in der klinischen Pflege (4).
Der Beitrag beschreibt die aktuellen Überlegungen zur Weiterentwicklung der informationswissenschaftlichen Studiengänge der Hochschule Hannover vor dem Hintergrund des laufenden Prozesses der Reakkreditierung. Zentrale Aspekte bilden hierbei die inhaltliche und strukturelle Weiterentwicklung des Curriculums vor dem Hintergrund der sich verändernden Bedürfnisse der Bibliotheken. Ebenfalls berücksichtigt werden verschiedene Formen der Kooperation mit der Bibliothekspraxis, hochschuldidaktische Überlegungen sowie die Einbindung der Studiengänge in die informationswissenschaftliche Forschungslandschaft.
Der Aufsatz erläutert anschaulich, wie der Transport der elektrischen Energie vom Erzeuger zum Verbraucher im Detail erfolgt. Die Rechnung mit Hilfe grundlegender Beziehungen aus den Grundlagen der Elektrotechnik und dem Poynting-Vektor ermöglicht es, den physikalisch realen Transport der Energie räumlich quantitativ nachzuvollziehen und zu verstehen. An vereinfachten Beispielen wird gezeigt, wie die Energie über zwei Sammelschienen zu den Verbrauchern und insbesondere in die Verbraucher hinein gelangt. Bei den Verbrauchern handelt es sich exemplarisch um einen Widerstand, einen Kondensator, eine Spule und schließlich einen bewegten Leiter im magnetischen Feld als einfachste Form eines Gleichstrommotors. Es wird dargestellt, dass die Energie keinesfalls in den Zuleitungen transportiert wird, sondern durch den umgebenden Raum.
Introduction
Atopic dermatitis (AD) is a common inflammatory skin disease. Many patients are initiating a systemic therapy, if the disease is not adequately controlled with topical treatment only. Currently, there is little real-world evidence on the AD-related medical care situation in Germany. This study analyzed patient characteristics, treatment patterns, healthcare resource utilization and costs associated with systemically treated AD for the German healthcare system.
Methods
In this descriptive, retrospective cohort study, aggregated anonymized German health claims data from the InGef research database were used. Within a representative sample of four million insured individuals, patients with AD and systemic drug therapy initiation (SDTI) in the index year 2017 were identified and included into the study cohort. Systemic drug therapy included dupilumab, systemic corticosteroids (SCS) and systemic immunosuppressants (SIS). Patients were observed for one year starting from the date of SDTI in 2017.
Results
9975 patients were included (57.8% female, mean age 39.6 years [SD 25.5]). In the one-year observation period, the most common systemic drug therapy was SCS (> 99.0%). Administrations of dupilumab (0.3%) or dispensations of SIS were rare (cyclosporine: 0.5%, azathioprine: 0.6%, methotrexate: 0.1%). Median treatment duration of SCS, cyclosporine and azathioprine was 27 days, 102 days, and 109 days, respectively. 2.8% of the patients received phototherapy; 41.6% used topical corticosteroids and/or topical calcineurin inhibitor. Average annual costs for medications amounted to € 1237 per patient. Outpatient services were used by 99.6% with associated mean annual costs of € 943; 25.4% had at least one hospitalization (mean annual costs: € 5836). 5.3% of adult patients received sickness benefits with associated mean annual costs of € 5026.
Conclusions
Despite unfavorable risk–benefit profile, this study demonstrated a common treatment with SCS, whereas other systemic drug therapy options were rarely used. Furthermore, the results suggest a substantial economic burden for patients with AD and SDTI.
Background: One of the major challenges in pediatric intensive care is the detection of life-threatening health conditions under acute time constraints and performance pressure. This includes the assessment of pediatric organ dysfunction (OD) that demands extraordinary clinical expertise and the clinician’s ability to derive a decision based on multiple information and data sources. Clinical decision support systems (CDSS) offer a solution to support medical staff in stressful routine work. Simultaneously, detection of OD by using computerized decision support approaches has been scarcely investigated, especially not in pediatrics.
Objectives: The aim of the study is to enhance an existing, interoperable, and rulebased CDSS prototype for tracing the progression of sepsis in critically ill children by augmenting it with the capability to detect SIRS/sepsis-associated hematologic OD, and to determine its diagnostic accuracy.
Methods: We reproduced an interoperable CDSS approach previously introduced by our working group: (1) a knowledge model was designed by following the commonKADS methodology, (2) routine care data was semantically standardized and harmonized using openEHR as clinical information standard, (3) rules were formulated and implemented in a business rule management system. Data from a prospective diagnostic study, including 168 patients, was used to estimate the diagnostic accuracy of the rule-based CDSS using the clinicians’ diagnoses as reference
In the context of the ongoing digitization of interdisciplinary subjects, the need for digital literacy is increasing in all areas of everyday life. Furthermore, communication between science and society is facing new challenges, not least since the COVID-19 pandemic. In order to deal with these challenges and to provide target-oriented online teaching, new educational concepts for the transfer of knowledge to society are necessary. In the transfer project “Zukunftslabor Gesundheit” (ZLG), a didactic concept for the creation of E-Learning classes was developed. A key factor for the didactic concept is addressing heterogeneous target groups to reach the broadest possible spectrum of participants. The concept has already been used for the creation of the first ZLG E-Learning courses. This article outlines the central elements of the developed didactic concept and addresses the creation of the ZLG courses. The courses created so far appeal to different target groups and convey diverse types of knowledge at different levels of difficulty.
The aim of the podcast Digitization of Medicine is to interest a broader audience and, in particular, young women, in research and work in the field of medical informatics. This article presents the usage figures and discusses their significance for further research on the success of science communication. By 24/02/2022, a total of 24,351 downloads had been made. There were slightly more female than male listeners, and they tended to be younger. Despite the importance podcast are gaining for science communication, little is known about the respective user group and further research is needed. In this context, this paper aims to help make the effectiveness of podcasts comparable.
A proven method to enhance the mechanical properties of additively manufactured plastic parts is the embedding of continuous fibers. Due to its great flexibility, continuous fiber-reinforced material extrusion allows fiber strands to be deposited along optimized paths. Nevertheless, the fibers have so far been embedded in the parts contour-based or on the basis of regular patterns. The outstanding strength and stiffness properties of the fibers in the longitudinal direction cannot be optimally utilized. Therefore, a method is proposed which allows to embed fibers along the principal stresses into the parts in a load-oriented manner. A G-code is generated from the calculated principal stress trajectories and the part geometry, which also takes into account the specific restrictions of the manufacturing technology used. A distinction is made between fiber paths and the matrix so that the average fiber volume content can be set in a defined way. To determine the mechanical properties, tensile and flexural tests are carried out on specimens consisting of carbon fiber-reinforced polyamide. In order to increase the influence of the principal stress-based fiber orientation, open-hole plates are used for the tensile tests, as this leads to variable stresses across the cross section. In addition, a digital image correlation system is used to determine the deformations during the mechanical tests. It was found that the peak load of the optimized open-hole plates was greater by a factor of 3 and the optimized flexural specimens by a factor of 1.9 than the comparison specimens with unidirectional fiber alignment.
Nowadays, problems related with solid waste management become a challenge for most countries due to the rising generation of waste, related environmental issues, and associated costs of produced wastes. Effective waste management systems at different geographic levels require accurate forecasting of future waste generation. In this work, we investigate how open-access data, such as provided from the Organisation for Economic Co-operation and Development (OECD), can be used for the analysis of waste data. The main idea of this study is finding the links between socioeconomic and demographic variables that determine the amounts of types of solid wastes produced by countries. This would make it possible to accurately predict at the country level the waste production and determine the requirements for the development of effective waste management strategies. In particular, we use several machine learning data regression (Support Vector, Gradient Boosting, and Random Forest) and clustering models (k-means) to respectively predict waste production for OECD countries along years and also to perform clustering among these countries according to similar characteristics. The main contributions of our work are: (1) waste analysis at the OECD country-level to compare and cluster countries according to similar waste features predicted; (2) the detection of most relevant features for prediction models; and (3) the comparison between several regression models with respect to accuracy in predictions. Coefficient of determination (R2), Mean Absolute Error (MAE), Root Mean Square Error (RMSE), and Mean Absolute Percentage Error (MAPE), respectively, are used as indices of the efficiency of the developed models. Our experiments have shown that some data pre-processings on the OECD data are an essential stage required in the analysis; that Random Forest Regressor (RFR) produced the best prediction results over the dataset; and that these results are highly influenced by the quality of available socio-economic data. In particular, the RFR model exhibited the highest accuracy in predictions for most waste types. For example, for “municipal” waste, it produced, respectively, R2 = 1 and MAPE = 4.31 global error values for the test set; and for “household” waste, it, respectively, produced R2 = 1 and MAPE = 3.03. Our results indicate that the considered models (and specially RFR) all are effective in predicting the amount of produced wastes derived from input data for the considered countries.
Entwicklung und Implementierung von Schutzkonzepten haben mit dem Kinder- und Jugendstärkungsgesetz (KJSG) im Juni 2021 in vielen Handlungsfeldern der Kinder- und Jugendhilfe eine rechtliche Grundlage bekommen. Sexualisierte Gewalt ist dabei eine spezifische Herausforderung, die entsprechende Kompetenzen, Qualifikationen und Strukturen erfordert. Dem Jugendamt kommt hierbei eine Schlüsselfunktion zu. Hochproblematische Fallverläufe haben zuletzt verdeutlicht, dass diese Schlüsselfunktion einer kritischen Überprüfung und systematischen Stärkung bedarf. Es gilt insbesondere, die Themen Qualifizierung, Hilfeplanung und Schutzkonzepte zu fokussieren. Erforderlich sind praxisnahe und bedarfsgerechte Wissensbestände, eine Stärkung der professionellen Handlungskompetenz, die Weiterentwicklung organisationaler Strukturen sowie die Etablierung eigenständiger Qualitätsstandards. Das Verbundvorhaben „Fokus Jugendamt – Partizipativer Wissenstransfer zu Kooperation, Hilfeplanung und Schutzkonzepten im Kontext sexualisierte Gewalt (FokusJA)“ greift diese Desiderate mit einem Forschungs- und Transferansatz auf.
Electrospinning with consequent thermal treatment consists in a carbon fiber production method that spins a polymer solution to create fibers with diameters around a few hundred nanometers. The thermal treatments are used for the cyclization and then carbonization of the material at 1700 °C for one hour. The unique structure of micro- and nano-carbon fibers makes them a promising material for various applications ranging from future battery designs to filtration. This work investigated the possibility of using milled gasification biochar, derived from a 20 kW fixed-bed gasifier fueled with vine pruning pellets, as an addictive in the preparation of electrospinning solutions. This study outlined that solvent cleaning and the consequent wet-milling and 32 µm sifting are fundamental passages for biochar preparation. Four different polyacrylonitrile-biochar shares were tested ranging from pure polymer to 50–50% solutions. The resulting fibers were analyzed via scanning electron microscopy, and energy-dispersive X-ray and infrared spectroscopy. Results from the morphological analysis showed that biochar grains dispersed themselves well among the fiber mat in all the proposed shares. All the tested solutions, once carbonized, exceeded 97%wt. of carbon content. At higher carbonization temperatures, the inorganic compounds naturally showing in biochar such as potassium and calcium disappeared, resulting in an almost carbon-pure fiber matrix with biochar grains in between.
Zu den Phänomenen digitalisierter Kommunikation ist inzwischen auch die Chatberatung zu zählen. Vor diesem Hintergrund zeigt sich die Notwendigkeit, Kommunikation via Chat phänomenologisch zu durchdringen, sozialtheoretisch einzuordnen und beratungsethisch kritisch zu reflektieren. Dies geschieht am Beispiel der Chatseelsorge, die zugleich von Beratung unterschieden wird.
Background: The globalization of clinical research should also benefit the population in developing markets. In this context, the approval of tested medicines and the associated expansion of medical care beyond clinical studies would be desirable as a possible long-term benefit.
Objectives: This study was designed to compare the development of the number of clinical trials with the number of marketing authorizations of medicines on the African continent. To contrast these 2 parameters, the data were analyzed using the model of an ecological study.
Methods: To reflect the broad spectrum of African developing countries with diverse levels of development, the data collection was based on 2 geographically selected sample countries each from Central, North, East, West, and Southern Africa. Based on the ClinicalTrials.gov registry, the first step was to collect trends data on the development of the clinical trials in the 10 selected countries of the country list of the African Region published by the World Health Organization for the period 2015 to 2018. Subsequently, data on the current number of marketing authorizations of medicines in the selected sample countries were identified using the online registries of the national authorities. The data were utilized in comparative analyses.
Results: Eight out of 10 model countries showed an increase in the number of clinical trials, with the exceptions of Cameroon and Libya, which showed an overall decline in research activity over the entire time. In direct comparison with drug registrations, the numbers indicate a similar development. The only exception here is Nigeria, a country with a solid performance in clinical research and yet a decrease in medicine registrations since 2015.
Conclusions: The expected increase in the development of clinical research as result of the globalization trend can basically be observed in most of the model countries. However, this increase does not guarantee an improvement in the number of medicine registrations. Although this is evident in some of the selected model countries, it cannot be projected to the entire African region. This may be linked to the diverse development of the individual countries due to the different political situations and the varying degrees of clinical research infrastructure.
Die Konvergenz von Netzwerken ist ein zunehmender Trend im Bereich der Automatisierung. Immer mehr Anlagenbetreiber streben eine Vereinheitlichung der Netzwerke in ihren Anlagen an. Dies führt zu einer nahtlosen Netzwerkstruktur, einer vereinfachten Überwachung und einem geringeren Schulungsaufwand für das Personal, da nur eine einheitliche Netzwerktechnologie gehandhabt werden muss. Ethernet-APL ist ein Teil des Puzzles für ein solches konvergentes Netzwerk und unterstützt verschiedene Echtzeitprotokolle wie PROFINET, EtherNet, HART-IP sowie das Middleware-Protokoll OPC UA. Dieses Papier gibt einen Überblick über die Auswirkungen von Ethernet-APL-Feldgeräten auf die OT-Sicherheit und schlägt vor, wie die OT-Sicherheit für diese Geräte gewährleistet werden kann.
Network convergence is an increasing trend in the automation domain. More and more plant owners strive for a unification of networks in their plants. This yields a seamless network structure, simplified supervision, and reduced training effort for the personnel, as only one unified network technology needs to be handled. Ethernet-APL is one piece of the puzzle for such a converged network, supporting various real time protocols like PROFINET, EtherNet, HART-IP as well as the middleware protocol OPC UA. This paper gives an overview on the impact of Ethernet-APL field devices to OT security and proposes how to ensure OT security for them.
Die gesetzlich vorgesehene Bereitstellung von Digitalisierungsangeboten stellt öffentliche Verwaltungen vor steigende Herausforderungen. Aufgrund der Heterogenität der Nutzerinnen und Nutzer ist es für öffentliche Verwaltungen häufig problematisch, klare Anforderungen zu erheben und zu erfüllen. Hinzukommen strukturelle und organisatorische Gegebenheiten wie beispielsweise ausgeprägte Entscheidungshierarchien, die eine nutzerzentrierte Vorgehensweise erschweren können. Darüber hinaus sieht sich die öffentliche Verwaltung zunehmend mit komplexer werdenden Problemen konfrontiert. Es stellt sich daher die Frage, wie in der öffentlichen Verwaltung ein moderner Ansatz zur Nutzerzentrierung und Problemlösung eingesetzt werden kann. Dieser Artikel präsentiert die Ergebnisse einer Einzelfallstudie bei der Niedersächsischen Landesbehörde für Straßenbau und Verkehr (NLStBV). Wir haben mit einer Fokusgruppe einen Design-Thinking-Workshop durchgeführt, um Potenziale und Anwendungsmöglichkeiten des Ansatzes in der öffentlichen Verwaltung zu identifizieren. Auf Basis einer SWOT-Analyse haben wir die Ergebnisse untersucht und geben vier konkrete Handlungsempfehlungen für die Einführung sowie Nutzung von Design Thinking.
We performed classical molecular dynamics simulations to model the scattering process of nitric oxide, NO, off graphene supported on gold. This is motivated by our desire to probe the energy transfer in collisions with graphene. Since many of these collision systems comprising of graphene and small molecules have been shown to scatter non-reactively, classical molecular dynamics appear to describe such systems sufficiently. We directed thousands of trajectories of NO molecules onto graphene along the surface normal, while varying impact position, but also speed, orientation, and rotational excitation of the nitric oxide, and compare the results with experimental data. While experiment and theory do not match quantitatively, we observe agreement that the relative amount of kineti cenergy lost during the collision increases with increasing initial kinetic energy of the NO. Furthermore, while at higher collision energies, all NO molecules lose some energy, and the vast majority of NO is scattered back, in contrast at low impact energies, the fraction of those nitric oxide molecules that are trapped at the surface increases, and some NO molecules even gain some kinetic energy during the collision process. The collision energy seems to preferentially go into the collective motion of the carbon atoms in the graphene sheet.
We present a methodology based on mixed-integer nonlinear model predictive control for a real-time building energy management system in application to a single-family house with a combined heat and power (CHP) unit. The developed strategy successfully deals with the switching behavior of the system components as well as minimum admissible operating time constraints by use of a special switch-cost-aware rounding procedure. The quality of the presented solution is evaluated in comparison to the globally optimal dynamic programming method and conventional rule-based control strategy. Based on a real-world scenario, we show that our approach is more than real-time capable while maintaining high correspondence with the globally optimal solution. We achieve an average optimality gap of 2.5% compared to 20% for a conventional control approach, and are faster and more scalable than a dynamic programming approach.