The 10 most recently published documents
Begleitheft zum Seminar "Psychology at Work - Selbstmanagement im Unternehmen und Authentic Leadership". Checklisten, Übungen, Arbeitsblätter, Links und Foliensätze. Zusätzlich zu den Videos und den Live online Einheiten enthält das Begleitheft die Video-Übungen zur besseren Übersicht und Bearbeitung, sowie zusätzliche online-Links und vertiefende Arbeitsblätter.
Begleitheft zum Seminar "Psychology at work. Positive Psychologie im Unternehmen und Positive Leadership". Checklisten, Übungen, Arbeitsblätter, Links und Foliensätze.
Zusätzlich zu den Videos und den Live online Einheiten enthält das Begleitheft die Video-Übungen zur besseren Übersicht und Bearbeitung, sowie zusätzliche online-Links und vertiefende Arbeitsblätter.
Der Artikel bespricht den zweiten Teil des Tagungsbands "Kontinuitäten und Diskontinuitäten Sozialer Arbeit nach dem Ende des Nationalsozialismus". Der Band wurde von Ralph-Christian Amthor, Carola Kuhlmann und Birgit Bender-Junker herausgegeben und enthält 17 Beiträge. Er beschäftigt sich mit der bisher wenig erforschten Nachkriegs- und Übergangszeit nach dem zweiten Weltkrieg in Bezug auf Kontinuitäten und Diskontinuitäten Sozialer Arbeit.
Entwicklung und Implementierung von Schutzkonzepten haben mit dem Kinder- und Jugendstärkungsgesetz (KJSG) im Juni 2021 in vielen Handlungsfeldern der Kinder- und Jugendhilfe eine rechtliche Grundlage bekommen. Sexualisierte Gewalt ist dabei eine spezifische Herausforderung, die entsprechende Kompetenzen, Qualifikationen und Strukturen erfordert. Dem Jugendamt kommt hierbei eine Schlüsselfunktion zu. Hochproblematische Fallverläufe haben zuletzt verdeutlicht, dass diese Schlüsselfunktion einer kritischen Überprüfung und systematischen Stärkung bedarf. Es gilt insbesondere, die Themen Qualifizierung, Hilfeplanung und Schutzkonzepte zu fokussieren. Erforderlich sind praxisnahe und bedarfsgerechte Wissensbestände, eine Stärkung der professionellen Handlungskompetenz, die Weiterentwicklung organisationaler Strukturen sowie die Etablierung eigenständiger Qualitätsstandards. Das Verbundvorhaben „Fokus Jugendamt – Partizipativer Wissenstransfer zu Kooperation, Hilfeplanung und Schutzkonzepten im Kontext sexualisierte Gewalt (FokusJA)“ greift diese Desiderate mit einem Forschungs- und Transferansatz auf.
Objective
Cyberknife robotic radiosurgery (RRS) provides single-session high-dose radiotherapy of brain tumors with a steep dose gradient and precise real-time image-guided motion correction. Although RRS appears to cause more radiation necrosis (RN), the radiometabolic changes after RRS have not been fully clarified. 18F-FET-PET/CT is used to differentiate recurrent tumor (RT) from RN after radiosurgery when MRI findings are indecisive. We explored the usefulness of dynamic parameters derived from 18F-FET PET in differentiating RT from RN after Cyberknife treatment in a single-center study population.
Methods
We retrospectively identified brain tumor patients with static and dynamic 18F-FET-PET/CT for suspected RN after Cyberknife. Static (tumor-to-background ratio) and dynamic PET parameters (time-activity curve, time-to-peak) were quantified. Analyses were performed for all lesions taken together (TOTAL) and for brain metastases only (METS). Diagnostic accuracy of PET parameters (using mean tumor-to-background ratio >1.95 and time-to-peak of 20 min for RT as cut-offs) and their respective improvement of diagnostic probability were analyzed.
Results
Fourteen patients with 28 brain tumors were included in quantitative analysis. Time-activity curves alone provided the highest sensitivities (TOTAL: 95%, METS: 100%) at the cost of specificity (TOTAL: 50%, METS: 57%). Combined mean tumor-to-background ratio and time-activity curve had the highest specificities (TOTAL: 63%, METS: 71%) and led to the highest increase in diagnosis probability of up to 16% p. – versus 5% p. when only static parameters were used.
Conclusions
This preliminary study shows that combined dynamic and static 18F-FET PET/CT parameters can be used in differentiating RT from RN after RRS.
Aim:
The most suitable method for assessment of response to peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors (NET) is still under debate. In this study we aimed to compare size (RECIST 1.1), density (Choi), Standardized Uptake Value (SUV) and a newly defined ZP combined parameter derived from Somatostatin Receptor (SSR) PET/CT for prediction of both response to PRRT and overall survival (OS).
Material and Methods:
Thirty-four NET patients with progressive disease (F:M 23:11; mean age 61.2 y; SD ± 12) treated with PRRT using either Lu-177 DOTATOC or Lu-177 DOTATATE and imaged with Ga-68 SSR PET/CT approximately 10–12 weeks prior to and after each treatment cycle were retrospectively analyzed. Median duration of follow-up after the first cycle was 63.9 months (range 6.2–86.2). A total of 77 lesions (2–8 per patient) were analyzed. Response assessment was performed according to RECIST 1.1, Choi and modified EORTC (MORE) criteria. In addition, a new parameter named ZP, the product of Hounsfield unit (HU) and SUVmean (Standard Uptake Value) of a tumor lesion, was tested. Further, SUV values (max and mean) of the tumor were normalized to SUV of normal liver parenchyma. Tumor response was defined as CR, PR, or SD. Gold standard for comparison of baseline parameters for prediction of response of individual target lesions to PRRT was change in size of lesions according to RECIST 1.1. For prediction of overall survival, the response after the first and second PRRT were tested.
Results:
Based on RECIST 1.1, Choi, MORE, and ZP, 85.3%, 64.7%, 61.8%, and 70.6% achieved a response whereas 14.7%, 35.3%, 38.2%, and 29.4% demonstrated PD (progressive disease), respectively. Baseline ZP and ZPnormalized were found to be the only parameters predictive of lesion progression after three PRRT cycles (AUC ZP 0.753; 95% CI 0.6–0.9, p 0.037; AUC ZPnormalized 0.766; 95% CI 0.6–0.9; p 0.029). Based on a cut-off-value of 1201, ZP achieved a sensitivity of 86% and a specificity of 67%, while ZPnormalized reached a sensitivity of 86% and a specificity of 76% at a cut-off-value of 198. Median OS in the total cohort was not reached. In univariate analysis amongst all parameters, only patients having progressive disease according to MORE after the second cycle of PRRT were found to have significantly shorter overall survival (median OS in objective responders not reached, in PD 29.2 months; p 0.015). Patients progressive after two cycles of PRRT according to ZP had shorter OS compared to those responding (median OS for responders not reached, for PD 47.2 months, p 0.066).
Conclusions:
In this explorative study, we showed that Choi, RECIST 1.1, and SUVmax-based response evaluation varied significantly from each other. Only patients showing progressive disease after two PRRT cycles according to MORE criteria had a worse prognosis while baseline ZP and
ZPnormalized performed best in predicting lesion progression after three cycles of PRRT.
High-performance firms typically have two features in common: (i) they produce in more than one country and (ii) they produce more than one product. In this paper, we analyze the internationalization strategies of multi-product firms. Guided by several new stylized facts, we develop a theoretical model to determine optimal modes of market access at the firm–product level. We find that the most productive firmssell core varieties via foreign direct investment and export products with intermediate productivity. Shocks to trade costs and technology affect the endogenous decision to export or produce abroad at the product-level and, in turn, the relative productivity between parents and affiliates.
Background
Symptoms of depression are prevalent in people living with human immune deficiency virus/acquired immune deficiency syndrome (PLWHA), and worsened by lack of physical activity/exercises, leading to restriction in social participation/functioning. This raises the question: what is the extent to which physical exercise training affected, symptoms of depression, physical activity level (PAL) and social participation in PLWHA compared to other forms of intervention, usual care, or no treatment controls?
Method
Eight databases were searched up to July 2020, according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) protocol. Only randomised controlled trials involving adults who were either on HAART/HAART-naïve and reported in the English language, were included. Two independent reviewers determined the eligibility of the studies, extracted data, assessed their quality, and risk of bias using the Physiotherapy Evidence Database (PEDro) tool. Standardised mean difference (SMD) was used as summary statistics for the mean primary outcome (symptoms of depression) and secondary outcomes (PAL and social participation) since different measuring tools/units were used across the included studies. Summary estimates of effects were determined using a random-effects model (I2).
Results
Thirteen studies met the inclusion criteria with 779 participants (n = 596 participants at study completion) randomised into the study groups, comprising 378 males, 310 females and 91 participants with undisclosed gender, and with an age range of 18–86 years. Across the studies, aerobic or aerobic plus resistance exercises were performed 2–3 times/week, at 40–60 min/session, and for between 6-24 weeks, and the risk of bias vary from high to low. Comparing the intervention to control groups showed significant difference in the symptoms of depression (SMD = − 0.74, 95% confidence interval (CI) − 1.01, − 0.48, p ≤ 0.0002; I2 = 47%; 5 studies; 205 participants) unlike PAL (SMD = 0.98, 95% CI − 0.25, 2.17, p = 0.11; I2 = 82%; 2 studies; 62 participants) and social participation (SMD = 0.04, 95% CI − 0.65, 0.73, p = 0.91; I2 = 90%; 6 studies; 373 participants).
Conclusion
Physical exercise training could have an antidepressant-like effect in PLWHA but did not affect PAL and social participation. However, the high heterogeneity in the included studies, implies that adequately powered randomised controlled trials with clinical/methodological similarity are required in future studies.
Die gesetzlich vorgesehene Bereitstellung von Digitalisierungsangeboten stellt öffentliche Verwaltungen vor steigende Herausforderungen. Aufgrund der Heterogenität der Nutzerinnen und Nutzer ist es für öffentliche Verwaltungen häufig problematisch, klare Anforderungen zu erheben und zu erfüllen. Hinzukommen strukturelle und organisatorische Gegebenheiten wie beispielsweise ausgeprägte Entscheidungshierarchien, die eine nutzerzentrierte Vorgehensweise erschweren können. Darüber hinaus sieht sich die öffentliche Verwaltung zunehmend mit komplexer werdenden Problemen konfrontiert. Es stellt sich daher die Frage, wie in der öffentlichen Verwaltung ein moderner Ansatz zur Nutzerzentrierung und Problemlösung eingesetzt werden kann. Dieser Artikel präsentiert die Ergebnisse einer Einzelfallstudie bei der Niedersächsischen Landesbehörde für Straßenbau und Verkehr (NLStBV). Wir haben mit einer Fokusgruppe einen Design-Thinking-Workshop durchgeführt, um Potenziale und Anwendungsmöglichkeiten des Ansatzes in der öffentlichen Verwaltung zu identifizieren. Auf Basis einer SWOT-Analyse haben wir die Ergebnisse untersucht und geben vier konkrete Handlungsempfehlungen für die Einführung sowie Nutzung von Design Thinking.
Der Beitrag beschreibt die aktuellen Überlegungen zur Weiterentwicklung der informationswissenschaftlichen Studiengänge der Hochschule Hannover vor dem Hintergrund des laufenden Prozesses der Reakkreditierung. Zentrale Aspekte bilden hierbei die inhaltliche und strukturelle Weiterentwicklung des Curriculums vor dem Hintergrund der sich verändernden Bedürfnisse der Bibliotheken. Ebenfalls berücksichtigt werden verschiedene Formen der Kooperation mit der Bibliothekspraxis, hochschuldidaktische Überlegungen sowie die Einbindung der Studiengänge in die informationswissenschaftliche Forschungslandschaft.
