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Welche Rolle zwischen Anpassung und Widerstand spielten die deutschen evangelischen Kirchen in der Zeit des Nationalsozialismus? Kämpften sie allein um ihre Selbsterhaltung als Organisation oder auch für die Wahrung der Menschenrechte außerhalb der Kirchenmauern? Wie gingen sie nach dem Ende des NS-Regimes mit ihrem eigenen Verhalten in den Jahren 1933-1945 um? Diesen Fragen geht Heinrich Grosse in acht Aufsätzen nach, die zusammenfassende Darstellungen kirchlichen Verhaltens sowie Forschungsergebnisse zu einzelnen Personen enthalten. An den Anfang hat er Untersuchungen über die evangelische Kirche und die Judenverfolgung gestellt, weil sich besonders hier zeigen musste, ob sie Kirche im Sinne Jesu war. Drei der Beiträge sind Studien zur regionalen Kirchengeschichte und konzentrieren sich auf die hannoversche Landeskirche, die größte der sog. intakten Landeskirchen im „Kirchenkampf“. Mit einer Vielzahl von konkreten Belegen fundiert der Verfasser seine Aussagen über die Rolle der Kirchen. Der Autor teilt die Auffassung Richard von Weizsäckers: „Wer vor der Vergangenheit die Augen verschließt, wird blind für die Gegenwart.“ Grosse ist überzeugt, dass die Kirchen an Glaubwürdigkeit und Zukunft gewinnen, wenn sie aufklärend und ehrlich mit ihrer eigenen Geschichte umgehen. Die acht Untersuchungen sollen einen Beitrag dazu leisten.

All of us are aware of the changes in the information field during the last years. We all see the paradigm shift coming up and have some idea how it will challenge our profession in the future. But how the road to excellence - in education of information specialists in the future - will look like? There are different models (new and old ones) for reorganising the structure of education: * Integration * Specialisation * Step-by step-model * Modul System * Network System / Combination model The paper will present the actual level of discussion on building up a new curriculum at the Department of Information and Communication (IK) at the FH Hannover. Based on the mission statement of the department »Education of information professionals is a part of the dynamic evolution of knowledge society« the direction of change and the main goals will be presented. The different reorganisation models will be explained with its objectives, opportunities and forms of implementation. Some examples will show the ideas and tools for a first draft of a reconstruction plan to become fit for the future. This talk has been held at the German-Dutch University Conference »Information Specialists for the 21st Century« at the Fachhochschule Hannover - University of Applied Sciences, Department of Information and Communication, October 14 -15, 1999 in Hannover, Germany.

Der Web-2.0-Selbstlernkurs "13 Dinge" wird vorgestellt.

Die Vorgängereinrichtungen der Evangelischen Fachhochschule Hannover. Hinweise zu ihrer Geschichte im Rahmen der Ausbildung für Sozialberufe.

Objectives: To assess the relation between the number of clinical trials conducted and respective new drug approvals in India and South Africa. Design: Construction and analysis of a comprehensive database of completed randomised controlled clinical trials based on clinicaltrials.gov from 1 January 2005 to 31 December 2010 and drug approval data from 2006 until 2013 for India and South Africa. Setting: USA, the EU, India and South Africa. Main outcome measures: Percentage of completed randomised clinical trials for an Investigational Medicinal Product (IMP) leading to new drug approval in India and South Africa. Results: A total of 622 eligible randomised controlled trials were identified as per search criteria for India and South Africa. Clustering them for the same sponsor and the same Investigational New Drug (IND) resulted in 453 eligible trials, that is, 224 for India and 229 for South Africa. The distribution of the market application approvals between the EU/USA as well as India and South Africa revealed that out of clinical trials with the participation of test centres in India and/or South Africa, 39.6% (India) clinical trials and 60.1% (South Africa) clinical trials led to market authorisation in the EU/USA without a New Drug Application (NDA) approval in India or South Africa. Conclusions: Despite an increase in clinical trial activities, there is a clear gap between the number of trials conducted and market availability of these new drugs in India and South Africa. Drug regulatory authorities, investigators, institutional review boards and patient groups should direct their efforts to ensuring availability of new drugs in the market that have been tested and researched on their population.

In this paper, we consider the route coordination problem in emergency evacuation of large smart buildings. The building evacuation time is crucial in saving lives in emergency situations caused by imminent natural or man-made threats and disasters. Conventional approaches to evacuation route coordination are static and predefined. They rely on evacuation plans present only at a limited number of building locations and possibly a trained evacuation personnel to resolve unexpected contingencies. Smart buildings today are equipped with sensory infrastructure that can be used for an autonomous situation-aware evacuation guidance optimized in real time. A system providing such a guidance can help in avoiding additional evacuation casualties due to the flaws of the conventional evacuation approaches. Such a system should be robust and scalable to dynamically adapt to the number of evacuees and the size and safety conditions of a building. In this respect, we propose a distributed route recommender architecture for situation-aware evacuation guidance in smart buildings and describe its key modules in detail. We give an example of its functioning dynamics on a use case.

Background: After kidney transplantation, immunosuppressive therapy causes impaired cellular immune defense leading to an increased risk of viral complications. Trough level monitoring of immunosuppressants is insufficient to estimate the individual intensity of immunosuppression. We have already shown that virus-specific T cells (Tvis) correlate with control of virus replication as well as with the intensity of immunosuppression. The multicentre IVIST01-trial should prove that additional steering of immunosuppressive and antiviral therapy by Tvis levels leads to better graft function by avoidance of over-immunosuppression (for example, viral infections) and drug toxicity (for example, nephrotoxicity). Methods/design: The IVIST-trial starts 4 weeks after transplantation. Sixty-four pediatric kidney recipients are randomized either to a non-intervention group that is only treated conservatively or to an intervention group with additional monitoring by Tvis. The randomization is stratified by centre and cytomegalovirus (CMV) prophylaxis. In both groups the immunosuppressive medication (cyclosporine A and everolimus) is adopted in the same target range of trough levels. In the non-intervention group the immunosuppressive therapy (cyclosporine A and everolimus) is only steered by classical trough level monitoring and the antiviral therapy of a CMV infection is performed according to a standard protocol. In contrast, in the intervention group the dose of immunosuppressants is individually adopted according to Tvis levels as a direct measure of the intensity of immunosuppression in addition to classical trough level monitoring. In case of CMV infection or reactivation the antiviral management is based on the individual CMV-specific immune defense assessed by the CMV-Tvis level. Primary endpoint of the study is the glomerular filtration rate 2 years after transplantation; secondary endpoints are the number and severity of viral infections and the incidence of side effects of immunosuppressive and antiviral drugs. Discussion: This IVIST01-trial will answer the question whether the new concept of steering immunosuppressive and antiviral therapy by Tvis levels leads to better future graft function. In terms of an effect-related drug monitoring, the study design aims to realize a personalization of immunosuppressive and antiviral management after transplantation. Based on the IVIST01-trial, immunomonitoring by Tvis might be incorporated into routine care after kidney transplantation.

Lemmatization is a central task in many NLP applications. Despite this importance, the number of (freely) available and easy to use tools for German is very limited. To fill this gap, we developed a simple lemmatizer that can be trained on any lemmatized corpus. For a full form word the tagger tries to find the sequence of morphemes that is most likely to generate that word. From this sequence of tags we can easily derive the stem, the lemma and the part of speech (PoS) of the word. We show (i) that the quality of this approach is comparable to state of the art methods and (ii) that we can improve the results of Part-of-Speech (PoS) tagging when we include the morphological analysis of each word.

Background: India has the third largest HIV epidemic in the world. The Indian epidemic is characterized by low levels in the general population and elevated concentrations among high-risk groups. The present study was planned to determine the awareness of HIV among students from Mumbai University. Methods: A cross-sectional study was carried out among students from Mumbai University, India during May–June 2017. Two hundred and fifty students were approached to participate in the study of which 199 agreed to participate (males: 132; females: 67). Pretested questionnaire was distributed and collected data was analyzed using IBM SPSS version 23. Results: Study participants had high knowledge (86%) and attitude score (87%). There was no significant difference between males and female participants for attitude and knowledge, except for one question regarding knowledge about HIV transmission via breastfeeding to child. Conclusions: Present study showed that there are no misconceptions or negative attitudes regarding HIV among students. A longitudinal study with a larger sample size across India is recommended for further investigation.

Immunization is the most cost-effective intervention for infectious diseases, which are the major cause of morbidity and mortality worldwide. Vaccines not only protect the individual who is vaccinated but also reduce the burden of infectious vaccine-preventable diseases for the entire community.1 Adult vaccination is very important given that >25% of mortality is due to infectious diseases.2 There is a scarcity of information on the vaccination status of young adults and the role of socioeconomic conditions in India.