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After kidney transplantation graft rejection must be prevented. Therefore, a multitude of parameters of the patient is observed pre- and postoperatively. To support this process, the Screen Reject research project is developing a data warehouse optimized for kidney rejection diagnostics. In the course of this project it was discovered that important information are only available in form of free texts instead of structured data and can therefore not be processed by standard ETL tools, which is necessary to establish a digital expert system for rejection diagnostics. Due to this reason, data integration has been improved by a combination of methods from natural language processing and methods from image processing. Based on state-of-the-art data warehousing technologies (Microsoft SSIS), a generic data integration tool has been developed. The tool was evaluated by extracting Banff-classification from 218 pathology reports and extracting HLA mismatches from about 1700 PDF files, both written in german language.
Background:
Hereditary angioedema (HAE) is a rare genetic disease and characterized by clinical features such as paroxysmal, recurrent angioedema of the skin, the gastrointestinal tract, and the upper airways. Swelling of the skin occurs primarily in the face, extremities and genitals. Gastrointestinal attacks are accompanied by painful abdominal cramps, vomiting and diarrhea. Due to the low prevalence and the fact that HAE patients often present with rather unspecific symptoms such as abdominal cramps, the final diagnosis is often made after a long delay. The aim of this German-wide survey was to characterize the period between occurrence of first symptoms and final diagnosis regarding self-perceived health, symptom burden and false diagnoses for patients with HAE.
Results:
Overall, 81 patients with HAE were included and participated in the telephone-based survey. Of those, the majority reported their current health status as “good” (47.5%) or “very good” (13.8%), which was observed to be a clear improvement compared to the year before final diagnosis (“good” (16.3%), “very good” (11.3%)). Edema in the extremities (85.2%) and in the gastrointestinal tract (81.5%) were the most currently reported symptoms and occurred earlier than other reported symptoms (mean age at onset 18.1 and 17.8 years, respectively). Misdiagnoses were observed in 50.6% of participating HAE patients with appendicitis and allergy being the most frequently reported misdiagnoses (40.0 and 30.0% of those with misdiagnosis, respectively). Patients with misdiagnosis often received mistreatment (80.0%) with pharmaceuticals and surgical interventions as the most frequently carried out mistreatments (65.6 and 56.3% of those with mistreatment, respectively). The mean observed diagnostic delay was 18.1 years (median 15.0 years). The diagnostic delay was higher in older patients and index patients.
Conclusions:
This study showed that self-perceived status of health for patients is much better once the final correct diagnosis has been made and specific treatment was available. Further challenge in the future will still be to increase awareness for HAE especially in settings which are normally approached by patients at occurrence of first symptoms to assure early referral to specialists and therefore increase the likelihood of receiving an early diagnosis.
Aim:
To characterize palliative care patients, to estimate the incidence, prevalence, and 1-year all-cause mortality in patients in Germany who received palliative care treatment.
Subject and methods:
The study analyzed the InGef Research Database, which covers 4 million people insured in German statutory health insurance companies. Specific outpatient and inpatient reimbursement codes were used to capture cases with palliative conditions. The prevalence was ascertained for the year 2015. The incidence was calculated for patients without documented palliative care services in the year before the observation period. The Kaplan–Meier method was used to analyze the 1-year all-cause mortality.
Results:
The incidence rate of palliative conditions was 41.3 and 34.9 per 10,000 persons in women and men, respectively. The prevalence per 10,000 persons was 61.3 in women and 51.1 in men. The 1-year all-cause mortality among patients receiving their first palliative care treatment was 67.5%. Mortality was lower in patients receiving general outpatient palliative care treatment (AAPV; 60.8%) compared to patients receiving specialized outpatient palliative care treatment (SAPV; 86.1%) or inpatient palliative care treatment (90.6%). Within the first 30 days, mortality was particularly high (~43.0%).
Conclusions:
In Germany, more than 400,000 patients per year receive palliative care treatment, which is lower compared to estimates of the number of persons with a potential need for palliative care. This gap was observed particularly in younger to middle-aged individuals. The findings indicate a demand for methodologically sound studies to investigate the public health burden and to quantify the unmet need for palliative care in Germany.
Background:
Multiple Sclerosis (MS) is a chronic inflammatory, immune mediated disease of the central nervous system, with Relapsing Remitting MS (RRMS) being the most common type. Within the last years, the status of high disease activity (HDA) has become increasingly important for clinical decisions. Nevertheless, little is known about the incidence, the characteristics, and the current treatment of patients with RRMS and HDA in Germany. Therefore, this study aims to estimate the incidence of HDA in a German RRMS patient population, to characterize this population and to describe current drug treatment routines and further healthcare utilization of these patients.
Methods:
A claims data analyses has been conducted, using a sample of the InGef Research Database that comprises data of approximately four million insured persons from around 70 German statutory health insurances (SHI). The study was conducted in a retrospective cohort design, including the years 2012–2016. Identification of RRMS population based on ICD-10 code (ICD-10-GM: G35.1). For identification of HDA, criteria from other studies as well as expert opinions have been used. Information on incidence, characteristics and current treatment of patients with RRMS and HDA was considered.
Results:
The overall HDA incidence within the RRMS population was 8.5% for 2016. It was highest for the age group of 0–19 years (29.4% women, 33.3% men) and lowest for the age group of ≥ 50 years (4.3% women, 5.6% men). Mean age of patients with RRMS and incident HDA was 38.4 years (SD: 11.8) and women accounted for 67.8%.
Analyses of drug utilization showed that 82.4% received at least one disease-modifying drug (DMD) in 2016. A percentage of 49.8% of patients received drugs for relapse therapy. A share of 55% of RRMS patients with HDA had at least one hospitalization with a mean length of stay of 13.9 days (SD: 18.3 days) in 2016. The average number of outpatient physician contacts was 28.1 (SD: 14.0).
Conclusions:
This study based on representative Germany-wide claims data from the SHI showed a high incidence of HDA especially within the young RRMS population. Future research should consider HDA as an important criterion for the quality of care for MS patients.
Self-directed learning is an essential basis for lifelong learning and requires constantly changing, target groupspecific and personalized prerequisites in order to motivate people to deal with modern learning content, not to overburden them and yet to adequately convey complex contexts. Current challenges in dealing with digital resources such as information overload, reduction of complexity and focus, motivation to learn, self-control or psychological wellbeing are taken up in the conception of learning settings within our QpLuS IM project for the study program Information Management and Information Management extra-occupational (IM) at the University of Applied Sciences and Arts Hannover. We present an interactive video on the functionality of search engines as a practical example of a medially high-quality and focused self-learning format that has been methodically produced in line with our agile, media-didactic process and stage model of complexity levels.
Digital data on tangible and intangible cultural assets is an essential part of daily life, communication and experience. It has a lasting influence on the perception of cultural identity as well as on the interactions between research, the cultural economy and society. Throughout the last three decades, many cultural heritage institutions have contributed a wealth of digital representations of cultural assets (2D digital reproductions of paintings, sheet music, 3D digital models of sculptures, monuments, rooms, buildings), audio-visual data (music, film, stage performances), and procedural research data such as encoding and annotation formats. The long-term preservation and FAIR availability of research data from the cultural heritage domain is fundamentally important, not only for future academic success in the humanities but also for the cultural identity of individuals and society as a whole. Up to now, no coordinated effort for professional research data management on a national level exists in Germany. NFDI4Culture aims to fill this gap and create a usercentered, research-driven infrastructure that will cover a broad range of research domains from musicology, art history and architecture to performance, theatre, film, and media studies.
The research landscape addressed by the consortium is characterized by strong institutional differentiation. Research units in the consortium's community of interest comprise university institutes, art colleges, academies, galleries, libraries, archives and museums. This diverse landscape is also characterized by an abundance of research objects, methodologies and a great potential for data-driven research. In a unique effort carried out by the applicant and co-applicants of this proposal and ten academic societies, this community is interconnected for the first time through a federated approach that is ideally suited to the needs of the participating researchers. To promote collaboration within the NFDI, to share knowledge and technology and to provide extensive support for its users have been the guiding principles of the consortium from the beginning and will be at the heart of all workflows and decision-making processes. Thanks to these principles, NFDI4Culture has gathered strong support ranging from individual researchers to highlevel cultural heritage organizations such as the UNESCO, the International Council of Museums, the Open Knowledge Foundation and Wikimedia. On this basis, NFDI4Culture will take innovative measures that promote a cultural change towards a more reflective and sustainable handling of research data and at the same time boost qualification and professionalization in data-driven research in the domain of cultural heritage. This will create a long-lasting impact on science, cultural economy and society as a whole.
Die Problematik der aktuell batteriebetriebenen Elektrofahrzeuge liegt in der geringen Reichweite, einem geringen Fahrtgastkomfort, sowie den langen Ladezeiten und einer nicht ausreichenden Ladeinfrastruktur. Diese Tatsachen stellen für die Nutzer eine Hürde für den Umstieg zu batteriebetriebenen Fahrzeugen dar. Eine schon heute verfügbare Brückentechnologie ist der Range Extender. Diese, meist im Fahrzeug integrierten Einheiten, liefern zusätzliche Reichweite, bei einer elektrischen Leistung von meist über 15 kWel und einem durchschnittlichen Anlagenwirkungsgrad von Ƞ RE ≈ 29 %. In dieser Arbeit wird ein modulares Konzept eines erweiterten Range Extenders untersucht, welches die Funktion der Kraft-Wärme-Kopplung und Kraft-Kälte-Kopplung nutzt. Diese Hilfseinheit soll zum einen den Nachteil der geringen Reichweite aufgrund der eingeschränkten Batteriekapazitäten, zum anderen den geringen thermischen Innenraumkomfort von batteriebetriebenen Fahrzeugen ausgleichen. Das Konzept einer Kraftwärme/-kältekopplung zur Klimatisierung von BEV wird in der vorliegenden Arbeit mit Hilfe eines Versuchsaufbaus messtechnisch und theoretisch mittels Simulation untersucht, sowie anhand der ermittelten Kennfelder beurteilt. Die Simulation basiert dabei auf empirisch ermittelten Daten. In den gewählten Fahrzeugklassen Kleinstwagen, Kompakt- und Mittelklasse wird der mittlere Gesamtwirkungsgrad der Anlagenkomponenten in Abhängigkeit von Klimadaten (Wetterdaten) bestimmt. Dieser ermittelte Wirkungsgrad ist abhängig von äußeren thermischen Anforderungen und der Ausnutzung der Anlagenkomponenten. Der modulierbare Leistungsbereich des mikro Blockheizkraftwerks mit Kraft-Kälte-Kopplung hat zum Heizen einen thermischen Leistungsbereich von 5,7 – 13,0 kWthh. Der mechanische Leistungsbereich von 2,0 - 14,5 kWme wird in zwei Bereiche aufgeteilt. Zur Kühlung wird ein thermischer Bereich von 1,0 – 7,0 kWthk und zur elektrischen Stromerzeugung ein Leistungsbereich von 1,0 – 6,0 kWel verwendet. Basierend auf den in dieser Arbeit experimentell ermittelten Kennfeldern, die unter Berücksichtigung der lokalen klimatischen Bedingungen in Deutschland berechnet wurden, kann der Anlagenwirkungsgrad für Kleinstwagen mit Ƞ Kl = 58,9 ± 3,5 %, für die Kompaktklasse mit Ƞ Ko = 62,2 ± 5,5 % und für die Mittelklasse mit durchschnittlich Ƞ Mk = 65,2 ± 4,8 % ermittelt werden. Die zusätzlich gewonnenen Reichweiten, die durch Einsparung von batterieelektrischer Energie für die Klimatisierung und durch Einspeisung von erzeugter elektrischer Energie erreicht werden, liegen bei den Kleinstwagen bei 246 ± 31 km, in der Kompaktklasse bei 296 ± 103 km und in der Mittelklasse bei 314 ± 104 km. Eine Abtrennung des Klimakompressors von der Verbrennungskraftmaschine führt dabei zusätzlich zu einer teilweisen Verbesserung der ermittelten Werte. Im Vergleich dazu, lässt sich ein durchschnittlicher Reichweitenzuwachs von 103 km, ohne den Einsatz eines Kraftstoffes, nur durch Nutzung eines effizienteren Systems erreichen, wenn eine Wärmepumpe eingesetzt wird. Zusammenfassend kann festgehalten werden, dass der Einsatz der Kraftwärme -Kältekopplung zur Klimatisierung von Elektrofahrzeugen nachhaltig und sinnvoller erscheint, als der Einsatz eines konventionellen Range Extender, denn der Einsatz eines zusätzlichen Kraftstoffes sollte so effizient wie möglich genutzt werden.
Rezension zu der Doppelausstellung "Zeitenwende 1400" des Dommuseums Hildesheim und des Landesmuseums Hannover. Während die Ausstellung im Hildesheimer Dommuseum ausgehend von der Stadt und dem Hochstift Hildesheim sowie der weiteren Region eine kulturhistorische Gesamtschau der Zeit um 1400 präsentiert, stellt die Ausstellung im Landesmuseum Hannover die Goldene Tafel aus der Benediktinerabteikirche St. Michaelis in Lüneburg, ein Flügelaltarretabel aus den ersten Jahrzehnten des 15. Jahrhunderts, als herausragendes Kunstwerk des Spätmittelalters in den Mittelpunkt.
Rezension zu:
Rösch, Hermann et al.: Bibliotheken und Informationsgesellschaft in Deutschland : eine Einführung / Hermann Rösch, Jürgen Seefeldt, Konrad Umlauf ; unter Mitarbeit von Albert Bilo und Eric W. Steinhauer ; mitbegründet von Engelbert Plassmann. – 3., neukonzipierte und aktualisierte Auflage. – Wiesbaden: Harrassowitz Verlag, 2019. – XIII, 329 Seiten. – ISBN 9783447066204 : EUR 39.80 (auch als EBook verfügbar)
Public knowledge and awareness towards antibiotics use in Yogyakarta: A cross sectional survey
(2020)
Irrational use of antibiotics is a public health problem. Our study aimed to evaluate knowledge and awareness of antibiotics, and to examine its’ associated factors. We conducted a cross sectional survey. The questionnaire was adapted from WHO Multi-country survey. Adults aged 18 years old and were receiving prescription from eight outpatient clinics and pharmacies in Yogyakarta province completed the survey. The questionnaire was consisted of three sections, i.e. socio-demographic factors, knowledge of antibiotics, and experiences in using antibiotics. Scores on questions and data were presented descriptively and analyzed using logistic regression to evaluate the influence of variables on knowledge of antibiotics. Out of 268 respondents, a cumulative 76% of them used antibiotics in last six months. Majority of respondents (58%) had low level knowledge on antibiotic use and awareness, and incorrectly identified that cold and cough are treatable with antibiotics (75%). Interestingly, 71% of participants agreed that internet is a major source of information on antibiotics (71%), while only 58% and 45% of respondents see pharmacists and medical professionals respectively. The antibiotics were received from prescription (79%) and 70% of respondents completed the full course of antibiotics prescribed, but only 32% of them became more cautious about antibiotic use. We found the highest association between gender, age, education level, with the knowledge of antibiotics. The overall level of knowledge and awareness on antibiotics use among residents in Yogyakarta is low. This mandates public health awareness intervention programs to be implemented on the use of antibiotics.
Within the HiGHmeducation consortium various online learning modules shall be developed by members of the consortium to address the increasing need for skilled professionals in a networked and digitalized healthcare system. Transferability of these modules to other locations is one main objective for the design of online learning modules. Thus, a didactical framework for online learning modules was developed. To ensure feasibility of the framework, the participating universities were analyzed concerning availability of e-learning support structures and infrastructures including learning management systems (LMS). The analysis especially focuses on the various LMS learning tools and their suitability for the framework. The framework is the basis for 12 HiGHmeducation online learning modules of which a part has firstly been conducted in winter 2019/20 and leads to a comparable structure of the modules.
Concreteness of words has been measured and used in psycholinguistics already for decades. Recently, it is also used in retrieval and NLP tasks. For English a number of well known datasets has been established with average values for perceived concreteness.
We give an overview of available datasets for German, their correlation and evaluate prediction algorithms for concreteness of German words. We show that these algorithms achieve similar results as for English datasets. Moreover, we show for all datasets there are no significant differences between a prediction model based on a regression model using word embeddings as features and a prediction algorithm based on word similarity according to the same embeddings.
Die vorliegende Arbeit befasst sich mit dem Trend "Gamification" und untersucht an Hand einer Szenario-Analyse, wie sich der Trend auf die Standgestaltung der B2B-Messen im Jahr 2030 auswirken wird.
Hierfür wurde intensive Literaturrecherche betrieben zu den Kernthemen: Gamification, Design, B2B-Messe und Trends im Messewesen.
Nach einer Auswertung dieser Themen in Bezug auf deren Kernelemente und Schlüsselkombinationen wurden 15 Zukunftsprojektionen erstellt, welche anschließend in 3 Szenarien zu Zukunftsbildern ausformuliert wurden.
Fazit der Arbeit ist, dass der Trend Gamification zwar an Bedeutung gewinnt, das Standdesign jedoch nur geringfügig beeinflussen wird. Andere Trendthemen wie Nachhaltigkeit, Sicherheit und die generelle Digitalisierung sowie ein Drang zu Kommunikation werden stärkeren Einfluss auf die Zukunft des Messewesens, und dadurch auch die Standgestaltung bei B2B-Messen, nehmen.
A study to assess the knowledge and attitude towards HIV of pharmacy students from Mumbai university
(2020)
Background: India is the biggest HIV epidemic in the world. The role of a pharmacist is pivotal in educating the general masses. The aim of the study was to determine the knowledge and attitude of pharmacy students from University of Mumbai.
Methods: A cross-sectional study was conducted in University of Mumbai during February-March 2020. Therein, 307 students (214: females and 94: males) participated in the study. The questionnaire was distributed in the classroom and data was collected by means of Google-forms. Furthermore, the data was analysed using IBM SPSS version 23.
Results: The participants demonstrated good knowledge (84%) and attitude (76%) score. With respect to knowledge score, no significant difference was observed except for responses of two questions, aim of the antiretroviral therapy (ART) and Avoidance of sexual intercourse can decrease the risk of HIV. With respect to attitude score, Volunteering to work at an institute for the welfare of HIV patients showed a significant difference.
Conclusion: The current study showed that there were no misconceptions or negative attitude regarding HIV among the students. However, a study with greater sample size must be conducted across India for further investigation.
The practice, attitude, and knowledge of complementary and alternative medicine in Mumbai, India
(2020)
Background: In the recent times, there has been a resurging interest in the use of complementary and alternative medicine (CAM) in India. The present study was conducted to examine the prevalence of CAM use in Mumbai, the knowledge and attitude regarding CAM regarding its safety and efficacy and the reasons for the use of CAM.
Methods: A cross-sectional study was conducted among the general population of Mumbai and its adjoining regions during January-July 2020. 205 residents participated in the study and were asked to fill a pretested questionnaire. The collected data was analyzed using IBM SPSS version 23.
Results: Out of the 205 responses, 163 (79.51%) agreed to have used CAM at least once in their life. Of these, 108 (52.68%) respondents used Ayurveda and 105 (51.21%) used homeopathy. 60 (36.81%) of the respondents practicing CAM used it for common gastrointestinal (GIT)-related disorder with a 100% recovery rate, 125 (76.67%) for infectious diseases with a 93.6% recovery rate. 99 (60.74%) of the respondents preferring CAM for its safety profile, 68 (41.72%) believed that CAM is time tested and thus is efficacious. An integrative approach was suggested by 118 (57.56%) of all the respondents.
Conclusions: There is a disparity between the high prevalence in the use of CAM and its knowledge. However, a general consensus suggests that CAM is efficacious and is practiced for various indications.
A descriptive cross-sectional study of cholera at Kakuma and Kalobeyei refugee camps, Kenya in 2018
(2020)
Introduction: cholera is a significant public health concern among displaced populations. Oral cholera vaccines are safe and can effectively be used as an adjunct to prevent cholera in settings with limited access to water and sanitation. Results from this study can inform future consideration for cholera vaccination at Kakuma and Kalobeyei.
Methods: a descriptive cross-sectional study of cholera cases at Kakuma refugee camp and Kalobeyei integrated settlement was carried out between May 2017 to May 2018 (one year). Data were extracted from the medical records and line lists at the cholera treatment centres.
Results: the results found 125 clinically suspected and confirmed cholera cases and one related death (CFR 0.8%). The cumulative incidence of all cases was 0.67 (95% CI=0.56-0.80) cases/1000 persons. Incidence of cholera was higher in children under the age of five 0.94(95% CI=0.63-1.36) cases/1000 persons. Children aged <5 years showed 51% increased risk of cholera compared to those aged ≥5 years (RR=1.51; 95% CI=1.00-2.31, p=0.051). Individuals from the Democratic Republic of Congo had nearly 9-fold risk of reporting cholera (RR=8.62; 95% CI=2.55-37.11, p<0.001) while individuals from South Sudan reported 7 times risk of cholera case compared to those from Somalia (RR=7.39; 95% CI=2.78-27.73, p<0.001).
Conclusion: in addition to the improvement of water, sanitation and hygiene (WaSH), vaccination could be implemented as a short-medium term measure of preventing cholera outbreaks. Age, country of origin and settlement independently predicted the risk of cholera.
Introduction:
Human Immunodeficiency Virus (HIV) infection remains prevalent co-morbidity, and among fracture patients. Few studies have investigated the role of exercise interventions in preventing bone demineralization in people who have fractures and HIV. If exercise exposed, HIV-infected individuals may experience improved bone health outcomes (BMD), function, quality of life (QoL). The study will aim to assess the impact of home based exercises on bone mineral density, functional capacity, QoL, and some serological markers of health in HIV infection among Nigerians and South Africans.
Methods and design:
The study is an assessor-blinded randomized controlled trial. Patients managed with internal and external fixation for femoral shaft fracture at the study sites will be recruited to participate in the study. The participants will be recruited 2 weeks post-discharge at the follow-up clinic with the orthopaedic surgeon. The study population will consist of all persons with femoral fracture and HIV-positive and negative (HIV-positive medically confirmed) aged 18 to 60 years attending the above-named health facilities. For the HIV-positive participants, a documented positive HIV result, as well as a history of being followed-up at the HIV treatment and care center. A developed home based exercise programme will be implemented in the experimental group while the control group continues with the usual rehabilitation programme. The primary outcome measures will be function, gait, bone mineral density, physical activity, and QoL.
Discussion:
The proposed trial will compare the effect of a home-based physical exercise-training programme in the management of femoral fracture to the usual physiotherapy management programmes with specific outcomes of bone mineral density, function, and inflammatory markers.
Das Forschungscluster Smart Data Analytics stellt in dem vorliegenden Band seine Forschung aus den Jahren 2019 und 2020 vor. In der ersten Hälfte des Bandes geben 20 Kurzporträts von laufenden oder kürzlich abgeschlossenen Projekten einen Überblick über die Forschungsthemen im Cluster. Enthalten in den Kurzporträts ist eine vollständige, kommentierte Liste der wissenschaftlichen Veröffentlichungen aus den Jahren 2019 und 2020. In der zweiten Hälfte dieses Bandes geben vier längere Beiträge exemplarisch einen tieferen Einblick in die Forschung des Clusters und behandeln Themen wie Fehlererkennung in Datenbanken, Analyse und Visualisierung von Sicherheitsvorfällen in Netzwerken, Wissensmodellierung und Datenintegration in der Medizin, sowie die Frage ob ein Computerprogramm Urheber eines Kunstwerkes im Sinne des Urheberrechts sein kann.
Die Gesellschaft ist geprägt von einem zunehmenden Bedürfnis nach Mitbestimmung und damit auch Beteiligung. In Zeiten mangelnder Wohnangebote ist das Interesse besonders groß, wenn bedeutsame Baumaßnahmen thematisiert werden und große Veränderungen mit sich bringen.
Die positive Resonanz auf innerstädtische Immobilienprojekte ist alles andere als selbstverständlich, dabei liegen die Interessen häufig eng beieinander. "Man wird natürlich nie alle zufriedenstellen können" aber häufig mangelt es an ausreichender Kommunikation und Aufklärungsarbeit.
Die Wissenschaftsarbeit beschäftigt sich mit der Frage, welche Ansprüche an Bürgerkommunikation bestehen und welche Chancen sich daraus für die Kommunikation von Bauprojekten ergeben. Daraus resultiert ein Lösungsansatz für die Immobilien-Public-Relations (PR).