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Background: Compromised immune function, associated with human immune deficiency virus (HIV) infection, is improved by antiretroviral therapy (ART) which also decreases bone mineral density (BMD), and possibly the quality of life (QoL). However, physical (aerobic/resistance) exercises, were reported to induce reverse effects in uninfected individuals and were appraised in the literature for evidence of similar benefits in people living with HIV/AIDS(PLWHA). The main study objective was to evaluate the impact of physical (aerobic and resistance) exercises on CD4+ count,
BMD and QoL in PLWHA.
Methods: A systematic review was conducted using the Cochrane Collaboration protocol. Searching databases, up to June 2017, only randomized control trials investigating the effects of either aerobic, resistance or a combination of both exercise types with a control/other intervention(s) for a period of at least 4 weeks among adults living with HIV, were included. Two independent reviewers determined the eligibility of the studies. Data were extracted and risk of bias (ROB) was assessed with the Cochrane Collaboration ROB tool. Meta-analyses were conducted using random effect models using the Review Manager (RevMan) computer software.
Results: Nineteen studies met inclusion criteria(n = 491 participants at study completion) comprising male and female with age range 22–66 years. Two meta-analyses across 13 sub-group comparisons were performed. However, there were no RCTs on the impact of physical exercises on BMD in PLWHA. The result showed no significant change in CD4+ count unlike a significant effect of 5.04 point (95%CI:-8.49,-3.74,p = 0.00001) for role activity limitation due to physical health (QoL sub-domain). Overall, the GRADE evidence for this review was of moderate quality.
Conclusions: There was evidence that engaging in moderate intensity aerobic exercises (55–85% Maximum heart rate-MHR), for 30–60 min, two to five times/week for 6–24 weeks significantly improves role activity limitation due to physical health problems, otherwise physical(aerobic or/and resistance) exercises have no significant effects on CD4+ count and other domains of QoL. Also, there is lack of evidence on the impact of exercises on BMD in PLWHA due to the paucity of RCTs. The moderate grade evidence for this review suggests that further research may likely have an important impact on our confidence in the estimate of effects and may change the estimate.
The trend towards the use of Ethernet in automation networks is ongoing. Due to its high flexibility, speed, and bandwidth, Ethernet nowadays is not only widely used in homes and offices worldwide but finding its way into industrial applications. Especially in automation processes, where many field devices send data in relative short time spans, the requirements for a safe and fast data transfer are high. This makes the use of industrial Ethernet essential. A new hardware-layer, specifically tailored for industrial applications, has been introduced in the form of Ethernet-APL (‘Advanced Physical Layer’). Ethernet-APL is based on the Ethernet standard and implements a two-wire Ethernet-based communication for field devices and provides data and power over a two-wire cable. The operation in areas with potentially explosive atmosphere is also possible. This enables a modular, fast, and transparent Ethernet network structure throughout the entire plant. However, by integrating Ethernet-APL into the field, industrial networks in the future will face the challenge of operating at varying datarates at different locations in the network, resulting in a ‘mixed link speed’ network. This can lead to limitations in packet-throughput and consequently to potential packet loss of system relevant data, which must be avoided. Therefore, the purpose of this thesis is to investigate the potential of packet loss in ‘mixed link speed’ networks.
Background
Symptoms of depression are prevalent in people living with human immune deficiency virus/acquired immune deficiency syndrome (PLWHA), and worsened by lack of physical activity/exercises, leading to restriction in social participation/functioning. This raises the question: what is the extent to which physical exercise training affected, symptoms of depression, physical activity level (PAL) and social participation in PLWHA compared to other forms of intervention, usual care, or no treatment controls?
Method
Eight databases were searched up to July 2020, according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) protocol. Only randomised controlled trials involving adults who were either on HAART/HAART-naïve and reported in the English language, were included. Two independent reviewers determined the eligibility of the studies, extracted data, assessed their quality, and risk of bias using the Physiotherapy Evidence Database (PEDro) tool. Standardised mean difference (SMD) was used as summary statistics for the mean primary outcome (symptoms of depression) and secondary outcomes (PAL and social participation) since different measuring tools/units were used across the included studies. Summary estimates of effects were determined using a random-effects model (I2).
Results
Thirteen studies met the inclusion criteria with 779 participants (n = 596 participants at study completion) randomised into the study groups, comprising 378 males, 310 females and 91 participants with undisclosed gender, and with an age range of 18–86 years. Across the studies, aerobic or aerobic plus resistance exercises were performed 2–3 times/week, at 40–60 min/session, and for between 6-24 weeks, and the risk of bias vary from high to low. Comparing the intervention to control groups showed significant difference in the symptoms of depression (SMD = − 0.74, 95% confidence interval (CI) − 1.01, − 0.48, p ≤ 0.0002; I2 = 47%; 5 studies; 205 participants) unlike PAL (SMD = 0.98, 95% CI − 0.25, 2.17, p = 0.11; I2 = 82%; 2 studies; 62 participants) and social participation (SMD = 0.04, 95% CI − 0.65, 0.73, p = 0.91; I2 = 90%; 6 studies; 373 participants).
Conclusion
Physical exercise training could have an antidepressant-like effect in PLWHA but did not affect PAL and social participation. However, the high heterogeneity in the included studies, implies that adequately powered randomised controlled trials with clinical/methodological similarity are required in future studies.
The reactivity of graphene at its boundary region has been imaged using non-linear spectroscopy to address the controversy whether the terraces of graphene or its edges are more reactive. Graphene was functionalised with phenyl groups, and we subsequently scanned our vibrational sum-frequency generation setup from the functionalised graphene terraces across the edges. A greater phenyl signal is clearly observed at the edges, showing evidence of increased reactivity in the boundary region. We estimate an upper limit of 1 mm for the width of the CVD graphene boundary region.
Background: Maintenance of metal homeostasis is crucial in bacterial pathogenicity as metal starvation is the most important mechanism in the nutritional immunity strategy of host cells. Thus, pathogenic bacteria have evolved sensitive metal scavenging systems to overcome this particular host defence mechanism. The ruminant pathogen Mycobacterium avium ssp. paratuberculosis (MAP) displays a unique gut tropism and causes a chronic progressive intestinal inflammation. MAP possesses eight conserved lineage specific large sequence polymorphisms (LSP), which distinguish MAP from its ancestral M. avium ssp. hominissuis or other M. avium subspecies. LSP14 and LSP15 harbour many genes proposed to be involved in metal homeostasis and have been suggested to substitute for a MAP specific, impaired mycobactin synthesis.
Results: In the present study, we found that a LSP14 located putative IrtAB-like iron transporter encoded by mptABC was induced by zinc but not by iron starvation. Heterologous reporter gene assays with the lacZ gene under control of the mptABC promoter in M. smegmatis (MSMEG) and in a MSMEGΔfurB deletion mutant revealed a zinc dependent, metalloregulator FurB mediated expression of mptABC via a conserved mycobacterial FurB recognition site. Deep sequencing of RNA from MAP cultures treated with the zinc chelator TPEN revealed that 70 genes responded to zinc limitation. Remarkably, 45 of these genes were located on a large genomic island of approximately 90 kb which harboured LSP14 and LSP15. Thirty-five of these genes were predicted to be controlled by FurB, due to the presence of putative binding sites. This clustering of zinc responsive genes was exclusively found in MAP and not in other mycobacteria.
Conclusions: Our data revealed a particular genomic signature for MAP given by a unique zinc specific locus, thereby suggesting an exceptional relevance of zinc for the metabolism of MAP. MAP seems to be well adapted to maintain zinc homeostasis which might contribute to the peculiarity of MAP pathogenicity.
Music streaming platforms offer music listeners an overwhelming choice of music. Therefore, users of streaming platforms need the support of music recommendation systems to find music that suits their personal taste. Currently, a new class of recommender systems based on knowledge graph embeddings promises to improve the quality of recommendations, in particular to provide diverse and novel recommendations. This paper investigates how knowledge graph embeddings can improve music recommendations. First, it is shown how a collaborative knowledge graph can be derived from open music data sources. Based on this knowledge graph, the music recommender system EARS (knowledge graph Embedding-based Artist Recommender System) is presented in detail, with particular emphasis on recommendation diversity and explainability. Finally, a comprehensive evaluation with real-world data is conducted, comparing of different embeddings and investigating the influence of different types of knowledge.
In der Bundesrepublik Deutschland gibt es rund 200000 Lieferstellen für Molkereiprodukte vom industriellen Großverbraucher bis zum Facheinzelhändler mit Milchproduktenangebot. Gut die Hälfte der gesamten Nachfrage schöpfen die Zentralläger sowie die Geschäfte des Lebensmitteleinzelhandels ab, wobei die Belieferung des LEH weitestgehend auf Strecke erfolgt. - Dipl.-Wirtsch.-Ing. Heinrich Wietbrauk von der Bundesanstalt für Milchforschung in Kiel analysiert für „dynamik im handel" die milchwirtschaftlichen Warenströme in Deutschland.
Hybride Arbeit: Wo und wie wollen Mitglieder agiler Softwareentwicklungsteams zukünftig arbeiten?
(2022)
Vor dem Ausbruch der COVID-19 Pandemie haben Mitglieder agiler Softwareentwicklungsteams üblicherweise gemeinsam im Büro gearbeitet. Durch die rasche Verbreitung des Coronavirus wurden diese Teams weltweit ins Home Office geschickt, um die Ausbreitung des Virus einzudämmen. Verschiedene Studien weisen darauf hin, dass viele Mitglieder agiler Softwareentwicklungsteams nach dem Ende der Pandemie nicht wieder in Vollzeit in das Büro zurückkehren wollen, sondern einen hybriden Ansatz zwischen dem Büro und dem Home Office präferieren. Das Ziel dieser Abschlussarbeit ist herauszufinden, wie Mitglieder agiler Softwareentwicklungsteams sich die Zukunft ihrer Arbeit vorstellen. Dazu wurde eine quantitative Datenerhebung in Form einer webbasierten Befragung mittels eines standardisierten Fragebogens unter Mitgliedern agiler Softwareentwicklungsteams durchgeführt. Das Ergebnis ist, dass eine flexible Wahl des Arbeitsortes erwartet wird, wobei das Home Office zukünftig der präferierte Arbeitsort sein wird. Einen Einfluss durch agile Rahmenwerke und den dazugehörigen Praktiken auf die Wahl des Arbeitsortes konnte nicht festgestellt werden. Für die Zukunft wird keine signifikante Produktivitätssteigerung durch ein hybrides Arbeitsmodell erwartet.
This paper describes the approach of the Hochschule Hannover to the SemEval 2013 Task Evaluating Phrasal Semantics. In order to compare a single word with a two word phrase we compute various distributional similarities, among which a new similarity measure, based on Jensen-Shannon Divergence with a correction for frequency effects. The classification is done by a support vector machine that uses all similarities as features. The approach turned out to be the most successful one in the task.