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A descriptive cross-sectional study of cholera at Kakuma and Kalobeyei refugee camps, Kenya in 2018
(2020)
Introduction: cholera is a significant public health concern among displaced populations. Oral cholera vaccines are safe and can effectively be used as an adjunct to prevent cholera in settings with limited access to water and sanitation. Results from this study can inform future consideration for cholera vaccination at Kakuma and Kalobeyei.
Methods: a descriptive cross-sectional study of cholera cases at Kakuma refugee camp and Kalobeyei integrated settlement was carried out between May 2017 to May 2018 (one year). Data were extracted from the medical records and line lists at the cholera treatment centres.
Results: the results found 125 clinically suspected and confirmed cholera cases and one related death (CFR 0.8%). The cumulative incidence of all cases was 0.67 (95% CI=0.56-0.80) cases/1000 persons. Incidence of cholera was higher in children under the age of five 0.94(95% CI=0.63-1.36) cases/1000 persons. Children aged <5 years showed 51% increased risk of cholera compared to those aged ≥5 years (RR=1.51; 95% CI=1.00-2.31, p=0.051). Individuals from the Democratic Republic of Congo had nearly 9-fold risk of reporting cholera (RR=8.62; 95% CI=2.55-37.11, p<0.001) while individuals from South Sudan reported 7 times risk of cholera case compared to those from Somalia (RR=7.39; 95% CI=2.78-27.73, p<0.001).
Conclusion: in addition to the improvement of water, sanitation and hygiene (WaSH), vaccination could be implemented as a short-medium term measure of preventing cholera outbreaks. Age, country of origin and settlement independently predicted the risk of cholera.
Background:
Hereditary angioedema (HAE) is a rare genetic disease and characterized by clinical features such as paroxysmal, recurrent angioedema of the skin, the gastrointestinal tract, and the upper airways. Swelling of the skin occurs primarily in the face, extremities and genitals. Gastrointestinal attacks are accompanied by painful abdominal cramps, vomiting and diarrhea. Due to the low prevalence and the fact that HAE patients often present with rather unspecific symptoms such as abdominal cramps, the final diagnosis is often made after a long delay. The aim of this German-wide survey was to characterize the period between occurrence of first symptoms and final diagnosis regarding self-perceived health, symptom burden and false diagnoses for patients with HAE.
Results:
Overall, 81 patients with HAE were included and participated in the telephone-based survey. Of those, the majority reported their current health status as “good” (47.5%) or “very good” (13.8%), which was observed to be a clear improvement compared to the year before final diagnosis (“good” (16.3%), “very good” (11.3%)). Edema in the extremities (85.2%) and in the gastrointestinal tract (81.5%) were the most currently reported symptoms and occurred earlier than other reported symptoms (mean age at onset 18.1 and 17.8 years, respectively). Misdiagnoses were observed in 50.6% of participating HAE patients with appendicitis and allergy being the most frequently reported misdiagnoses (40.0 and 30.0% of those with misdiagnosis, respectively). Patients with misdiagnosis often received mistreatment (80.0%) with pharmaceuticals and surgical interventions as the most frequently carried out mistreatments (65.6 and 56.3% of those with mistreatment, respectively). The mean observed diagnostic delay was 18.1 years (median 15.0 years). The diagnostic delay was higher in older patients and index patients.
Conclusions:
This study showed that self-perceived status of health for patients is much better once the final correct diagnosis has been made and specific treatment was available. Further challenge in the future will still be to increase awareness for HAE especially in settings which are normally approached by patients at occurrence of first symptoms to assure early referral to specialists and therefore increase the likelihood of receiving an early diagnosis.
A study to assess the knowledge and attitude towards HIV of pharmacy students from Mumbai university
(2020)
Background: India is the biggest HIV epidemic in the world. The role of a pharmacist is pivotal in educating the general masses. The aim of the study was to determine the knowledge and attitude of pharmacy students from University of Mumbai.
Methods: A cross-sectional study was conducted in University of Mumbai during February-March 2020. Therein, 307 students (214: females and 94: males) participated in the study. The questionnaire was distributed in the classroom and data was collected by means of Google-forms. Furthermore, the data was analysed using IBM SPSS version 23.
Results: The participants demonstrated good knowledge (84%) and attitude (76%) score. With respect to knowledge score, no significant difference was observed except for responses of two questions, aim of the antiretroviral therapy (ART) and Avoidance of sexual intercourse can decrease the risk of HIV. With respect to attitude score, Volunteering to work at an institute for the welfare of HIV patients showed a significant difference.
Conclusion: The current study showed that there were no misconceptions or negative attitude regarding HIV among the students. However, a study with greater sample size must be conducted across India for further investigation.
Background: We sought to develop and test an objective scorecard-based system for assessing and categorizing available research sites in Lassa fever-affected countries based on their preparedness and capability to host Lassa fever vaccine clinical trials.
Methods: We mapped available clinical research sites through interrogation of online clinical trial registries and relevant disease-based consortia. A structured online questionnaire was used to assess the capability of clinical trial sites to conduct Lassa fever vaccine clinical trials. We developed a new scoring template by allocating scores to questionnaire parameters based on perceived importance to the conduct of clinical trials as described in the WHO/TDR Global Competency Framework for Clinical Research. Cutoff points of 75% and 50% were used to categorize sites into categories A, B, or C.
Results: This study identified 44 clinical trial sites in 8 Lassa fever-affected countries. Out of these, 35 sites were characterized based on their capacity to hold Lassa fever vaccine clinical trials. A total of 14 sites in 4 countries were identified as ready to host Lassa fever vaccine trials immediately or with little support.
Conclusion: It is feasible to hold Lassa fever vaccine trials in affected countries based on the outcome of the survey. However, the findings are to be validated through sites' visits. This experience with a standardized and objective method of the site assessment is encouraging, and the site selection method used can serve as an orientation to sponsors and researchers planning clinical trials in the region.
Die Nutzung von Messenger-Diensten hat die Nutzung von sozialen Medien übertroffen. Diese Mediennutzung bringt veränderte Erwartungen an Unternehmen mit sich. Unternehmen begegnen den Erwartungen ihrer Kund*innen in der Online-Kundenkommunikation mit dem Einsatz textbasierter Dialogsysteme. Im Facebook-Messenger wurden 2018 bereits über 300.000 Chatbots angeboten. Das Problem ist, dass Studien seit mehreren Jahren aufzeigen, dass diese Kommunikationstechnologie sich bei den Kund*innen noch nicht durchgesetzt hat und häufig noch skeptisch betrachtet wird. Für Unternehmen ist es daher notwendig zu verstehen, welche Kriterien erfüllt sein müssen, um die Akzeptanzbildung der Kund*innen gegenüber textbasierten Dialogsystemen positiv zu beeinflussen.
Das Ziel dieser Arbeit ist es zu betrachten, inwiefern die Eigenschaften textbasierter Dialogsysteme die Akzeptanzkriterien der Kund*innen erfüllen können. Dazu wird die folgende Forschungsfrage gestellt: Wie akzeptieren Kunden den Einsatz textbasierter Dialogsysteme in der Online-Kundenkommunikation von Unternehmen?
Um die Forschungsfrage zu beantworten, wird eine Literaturanalyse durchgeführt. Die Literatur wird mit Studienergebnissen verglichen, um Übereinstimmungen und Abweichungen herauszuarbeiten.
Eine Akzeptanzanalyse hat ergeben, dass Kund*innen textbasierte Dialogsysteme vor allem akzeptieren, wenn sie darin einen Nutzen erkennen. Jedoch beeinflussen neben nutzenorientierten Faktoren auch emotionale Faktoren die Akzeptanz.
Auf dieser Grundlage ist es empfehlenswert, positive und negative Einflussfaktoren des Akzeptanzprozesses zu identifizieren und die Gestaltung textbasierter Dialogsysteme an die Kund*innen anzupassen, bevor diese eingesetzt werden.
Die Bachelorarbeit "Content-Strategien im Luxusmodemarketing" befasst sich mit den jeweiligen Besonderheiten von Content-Strategie und Luxusmodemarketing. Diese Ansatzpunkte werden zur Hilfe genommen, um die jeweiligen Disziplinen aufeinander zu beziehen. Dabei spielen bei der Content-Strategie die Faktoren Zielgruppe, Zeitpunkt, Inhalt, Kanäle und Formate eine übergeordnete Rolle, während im Luxusmodemarketing die Symbolkraft der Marke, die Saisonalität der Mode, die Visualität sowie die Akzeptanz seitens des Konsumenten von Bedeutung sind. Mithilfe dieser Kernaspekte, die in dieser Arbeit anhand von Theorien und Modellen untersucht werden, können Bezugspunkte zu den beiden Disziplinen hergestellt werden.
Der Theorieteil erläutert diese Facetten und arbeitet heraus, welche genauen Muster innerhalb der Content-Strategie sowie des Luxusmodemarketings vorliegen. Schließlich beschreibt der Anwendungsteil, wie die relevanten Zielgruppen, die passenden Inhalte, der richtige Zeitpunkt, die erforderlichen Kanäle und die angemessenen Formate auszusehen haben, um eine Content-Strategie erfolgreich im Luxusmodemarketing zu implementieren. Diese Arbeit versucht dies anhand der gewonnenen theoretischen Erkenntnisse sowie entsprechenden Praxisbeispielen näher zu betrachten.
Correction to: https://doi.org/10.1186/s12913-018-3862-7
In the original publication of this article, the authors missed that reverse coding was necessary for the item “Do you work separate from your colleagues?” before calculating the scale ‘social relations’. So they corrected the analysis accordingly. The results with the revised scale show that there are no longer any significant differences between nurses and physicians with regard to this scale.
Die Gesellschaft ist geprägt von einem zunehmenden Bedürfnis nach Mitbestimmung und damit auch Beteiligung. In Zeiten mangelnder Wohnangebote ist das Interesse besonders groß, wenn bedeutsame Baumaßnahmen thematisiert werden und große Veränderungen mit sich bringen.
Die positive Resonanz auf innerstädtische Immobilienprojekte ist alles andere als selbstverständlich, dabei liegen die Interessen häufig eng beieinander. "Man wird natürlich nie alle zufriedenstellen können" aber häufig mangelt es an ausreichender Kommunikation und Aufklärungsarbeit.
Die Wissenschaftsarbeit beschäftigt sich mit der Frage, welche Ansprüche an Bürgerkommunikation bestehen und welche Chancen sich daraus für die Kommunikation von Bauprojekten ergeben. Daraus resultiert ein Lösungsansatz für die Immobilien-Public-Relations (PR).
Introduction:
Human Immunodeficiency Virus (HIV) infection remains prevalent co-morbidity, and among fracture patients. Few studies have investigated the role of exercise interventions in preventing bone demineralization in people who have fractures and HIV. If exercise exposed, HIV-infected individuals may experience improved bone health outcomes (BMD), function, quality of life (QoL). The study will aim to assess the impact of home based exercises on bone mineral density, functional capacity, QoL, and some serological markers of health in HIV infection among Nigerians and South Africans.
Methods and design:
The study is an assessor-blinded randomized controlled trial. Patients managed with internal and external fixation for femoral shaft fracture at the study sites will be recruited to participate in the study. The participants will be recruited 2 weeks post-discharge at the follow-up clinic with the orthopaedic surgeon. The study population will consist of all persons with femoral fracture and HIV-positive and negative (HIV-positive medically confirmed) aged 18 to 60 years attending the above-named health facilities. For the HIV-positive participants, a documented positive HIV result, as well as a history of being followed-up at the HIV treatment and care center. A developed home based exercise programme will be implemented in the experimental group while the control group continues with the usual rehabilitation programme. The primary outcome measures will be function, gait, bone mineral density, physical activity, and QoL.
Discussion:
The proposed trial will compare the effect of a home-based physical exercise-training programme in the management of femoral fracture to the usual physiotherapy management programmes with specific outcomes of bone mineral density, function, and inflammatory markers.