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Impact of exercise training on symptoms of depression, physical activity level and social participation in people living with HIV/AIDS: a systematic review and meta-analysis

  • Background Symptoms of depression are prevalent in people living with human immune deficiency virus/acquired immune deficiency syndrome (PLWHA), and worsened by lack of physical activity/exercises, leading to restriction in social participation/functioning. This raises the question: what is the extent to which physical exercise training affected, symptoms of depression, physical activity level (PAL) and social participation in PLWHA compared to other forms of intervention, usual care, or no treatment controls? Method Eight databases were searched up to July 2020, according to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) protocol. Only randomised controlled trials involving adults who were either on HAART/HAART-naïve and reported in the English language, were included. Two independent reviewers determined the eligibility of the studies, extracted data, assessed their quality, and risk of bias using the Physiotherapy Evidence Database (PEDro) tool. Standardised mean difference (SMD) was used as summary statistics for the mean primary outcome (symptoms of depression) and secondary outcomes (PAL and social participation) since different measuring tools/units were used across the included studies. Summary estimates of effects were determined using a random-effects model (I2). Results Thirteen studies met the inclusion criteria with 779 participants (n = 596 participants at study completion) randomised into the study groups, comprising 378 males, 310 females and 91 participants with undisclosed gender, and with an age range of 18–86 years. Across the studies, aerobic or aerobic plus resistance exercises were performed 2–3 times/week, at 40–60 min/session, and for between 6-24 weeks, and the risk of bias vary from high to low. Comparing the intervention to control groups showed significant difference in the symptoms of depression (SMD = − 0.74, 95% confidence interval (CI) − 1.01, − 0.48, p ≤ 0.0002; I2 = 47%; 5 studies; 205 participants) unlike PAL (SMD = 0.98, 95% CI − 0.25, 2.17, p = 0.11; I2 = 82%; 2 studies; 62 participants) and social participation (SMD = 0.04, 95% CI − 0.65, 0.73, p = 0.91; I2 = 90%; 6 studies; 373 participants). Conclusion Physical exercise training could have an antidepressant-like effect in PLWHA but did not affect PAL and social participation. However, the high heterogeneity in the included studies, implies that adequately powered randomised controlled trials with clinical/methodological similarity are required in future studies.

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Author:Sam Chidi IbenemeORCiD, Victor Chukwuebuka Uwakwe, Hellen Myezwa, Franklin Onyedinma Irem, Fortune Elochukwu Ezenwankwo, Tunde Adedayo Ajidahun, Amarachi Destiny Ezuma, Uchenna Prosper Okonkwo, Gerhard FortwengelORCiDGND
URN:urn:nbn:de:bsz:960-opus4-24303
DOI:https://doi.org/10.25968/opus-2430
DOI original:https://doi.org/10.1186/s12879-022-07145-4
ISSN:1471-2334
Parent Title (English):BMC Infectious Deseases
Document Type:Article
Language:English
Year of Completion:2022
Publishing Institution:Hochschule Hannover
Release Date:2023/01/19
Tag:Exercise training; HIV/AIDS; Mental health; Physical activity level; Social participation
GND Keyword:HIV; Aids; Bewegungstherapie; Psychische Gesundheit; Körperliche Leistungsfähigkeit; Teilhabe
Volume:22
Article Number:469
Link to catalogue:1840127929
Institutes:Fakultät III - Medien, Information und Design
DDC classes:610 Medizin, Gesundheit
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International