Volltext-Downloads (blau) und Frontdoor-Views (grau)

Antimicrobial Activity of a Phage Mixture and a Lactic Acid Bacterium against Staphylococcus aureus from Bovine Mastitis

  • The antimicrobial activity of a phagemixture and a lactic acid bacteriumagainst Staphylococcus aureus isolates from bovine origin was investigated in vitro with regard to possible applications in the therapy of udder inflammation (mastitis) caused by bacterial infections. The S. aureus isolates used for inoculation derived from quarter foremilk samples of mastitis cases. For the examination of the antimicrobial activity, the reduction of the S. aureus germ density was determined [log10 cfu/mL]. The phage mixture consisted of the three obligatory lytic and S. aureus-specific phages STA1.ST29, EB1.ST11 and EB1.ST27 (1:1:1). The selected Lactobacillus plantarum strain with proven antimicrobial properties and the phage mixture were tested against S. aureus in milk, both alone and in combination. The application of the lactic acid bacterium showed only a low reduction ability for a 24 h incubation period. The bacteriophage mixture as well as its combination with the lactic acid bacterium showed high antimicrobial activity against S. aureus for a 24 h incubation period at 37 � C, with only the phage mixture showing significance.

Download full text files

Export metadata

Additional Services

Search Google Scholar


Author:Isabel Titze, Volker KrömkerORCiDGND
DOI original:https://doi.org/10.3390/vetsci7010031
Parent Title (English):Veterinary Sciences
Document Type:Article
Year of Completion:2020
Publishing Institution:Hochschule Hannover
Release Date:2020/04/16
Tag:bacteriophage mixture; bovine mastitis; dairy; lactic acid bacterium; lytic phage; phage therapy
GND Keyword:Staphylococcus aureus; Bakteriophagen; Therapie; Euterentzündung; Rind
Link to catalogue:1694794385
Institutes:Fakultät II - Maschinenbau und Bioverfahrenstechnik
DDC classes:630 Landwirtschaft, Veterinärmedizin
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International