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Accuracy of Magnetometer-Guided Sentinel Lymphadenectomy after Intraprostatic Injection of Superparamagnetic Iron Oxide Nanoparticles in Prostate Cancer: The SentiMag Pro II Study

  • Radioisotope-guided sentinel lymph node dissection (sLND) has shown high diagnostic reliability in prostate (PCa) and other cancers. To overcome the limitations of the radioactive tracers, magnetometer-guided sLND using superparamagnetic iron oxide nanoparticles (SPIONs) has been successfully used in PCa. This prospective study (SentiMag Pro II, DRKS00007671) determined the diagnostic accuracy of magnetometer-guided sLND in intermediate- and high-risk PCa. Fifty intermediate- or high-risk PCa patients (prostate-specific antigen (PSA) >= 10 ng/mL and/or Gleason score >= 7; median PSA 10.8 ng/mL, IQR 7.4–19.2 ng/mL) were enrolled. After the intraprostatic SPIONs injection a day earlier, patients underwent magnetometer-guided sLND and extended lymph node dissection (eLND, followed by radical prostatectomy. SLNs were detected in in vivo and in ex vivo samples. Diagnostic accuracy of sLND was assessed using eLND as the reference. SLNs were detected in all patients (detection rate 100%), with 447 sentinel lymph nodes SLNs (median 9, IQR 6–12) being identified and 966 LNs (median 18, IQR 15–23) being removed. Thirty-six percent (18/50) of patients had LN metastases (median 2, IQR 1–3). Magnetometer-guided sLND had 100% sensitivity, 97.0% specificity, 94.4% positive predictive value, 100% negative predictive value, 0.0% false negative rate, and 3.0% additional diagnostic value (LN metastases only in SLNs outside the eLND template). In vivo, one positive SLN/LN-positive patient was missed, resulting in a sensitivity of 94.4%. In conclusion, this new magnetic sentinel procedure has high accuracy for nodal staging in intermediate- and high-risk PCa. The reliability of intraoperative SLN detection using this magnetometer system requires verification in further multicentric studies.

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Metadaten
Author:Alexander Winter, Svenja Engels, Philipp Goos, Marie-Christin Süykers, Stefan Gudenkauf, Rolf-Peter Henke, Friedhelm Wawroschek
URN:urn:nbn:de:bsz:960-opus4-15539
DOI:https://doi.org/10.25968/opus-1553
DOI original:https://doi.org/10.3390/cancers12010032
ISSN:2072-6694
Parent Title (English):Cancers
Publisher:MDPI
Document Type:Article
Language:English
Year of Completion:2019
Publishing Institution:Hochschule Hannover
Release Date:2020/01/08
Tag:SPION; lymphadenectomy; magnetometer; prostate cancer; sentinel lymph node dissection; superparamagnetic iron oxide nanoparticles
GND Keyword:Sentinel-Lymphknoten; Prostatakrebs; Magnetometer; Lymphknoten
Volume:12
Issue:1
Link to catalogue:1687976996
Institutes:Fakultät IV - Wirtschaft und Informatik
DDC classes:610 Medizin, Gesundheit
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International