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Selective treatment of nonsevere clinical mastitis does not adversely affect cure, somatic cell count, milk yield, recurrence, or culling: A systematic review and meta-analysis

  • Treatment of clinical mastitis (CM) contributes to antimicrobial use on dairy farms. Selective treatment of CM based on bacterial diagnosis can reduce antimicrobial use, as not all cases of CM will benefit from antimicrobial treatment, e.g., mild and moderate gram-negative infections. However, impacts of selective CM treatment on udder health and culling are not fully understood. A systematic search identified 13 studies that compared selective versus blanket CM treatment protocols. Reported outcomes were synthesized with random-effects models and presented as risk ratios or mean differences. Selective CM treatment protocol was not inferior to blanket CM treatment protocol for the outcome bacteriological cure. Noninferiority margins could not be established for the outcomes clinical cure, new intramammary infection, somatic cell count, milk yield, recurrence, or culling. However, no differences were detected between selective and blanket CM treatment protocols using traditional analyses, apart from a not clinically relevant increase in interval from treatment to clinical cure (0.4 d) in the selective group and higher proportion of clinical cure at 14 d in the selective group. The latter occurred in studies co-administering nonsteroidal anti-inflammatories only in the selective group. Bias could not be ruled out in most studies due to suboptimal randomization, although this would likely only affect subjective outcomes such as clinical cure. Hence, findings were supported by a high or moderate certainty of evidence for all outcome measures except clinical cure. In conclusion, this review supported the assertion that a selective CM treatment protocol can be adopted without adversely influencing bacteriological and clinical cure, somatic cell count, milk yield, and incidence of recurrence or culling.

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Author:Ellen de Jong, Lien CreytensORCiD, Sarne De VliegherORCiD, Kayley D. McCubbinORCiD, Mya BaptisteORCiD, Alexander A. Leung, David SpeksnijderORCiD, Simon DufourORCiD, John R. MiddletonORCiD, Pamela L. RueggORCiD, Theo J. G. M. LamORCiD, David F. KeltonORCiD, Scott McDougalORCiD, Sandra M. GoddenORCiD, Alfonso LagoORCiD, Päivi J. Rajala-SchultzORCiD, Karin OrselORCiD, Volker KrömkerORCiDGND, John P. KastelicORCiD, Herman W. BarkemaORCiD
URN:urn:nbn:de:bsz:960-opus4-31984
DOI:https://doi.org/10.25968/opus-3198
DOI original:https://doi.org/10.3168/jds.2022-22271
ISSN:1525-3198
Parent Title (English):Journal of Dairy Science
Publisher:Elsevier
Document Type:Article
Language:English
Year of Completion:2023
Publishing Institution:Hochschule Hannover
Release Date:2024/07/10
Tag:antimicrobial stewardship; bacteriological cure; clinical mastitis; noninferiority; rapid diagnostic test
GND Keyword:Euterentzündung; Nichtunterlegenheitstest
Volume:106
Issue:2
First Page:1267
Last Page:1286
Institutes:Fakultät II - Maschinenbau und Bioverfahrenstechnik
DDC classes:630 Landwirtschaft, Veterinärmedizin
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International