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A New Approach to Understanding Cancer-Related Fatigue: Leveraging the 3P Model to Facilitate Risk Prediction and Clinical Care

  • A major gap impeding development of new treatments for cancer-related fatigue is an inadequate understanding of the complex biological, clinical, demographic, and lifestyle mechanisms underlying fatigue. In this paper, we describe a new application of a comprehensive model for cancer-related fatigue: the predisposing, precipitating, and perpetuating (3P) factors model. This model framework outlined herein, which incorporates the emerging field of metabolomics, may help to frame a more in-depth analysis of the etiology of cancer-related fatigue as well as a broader and more personalized set of approaches to the clinical treatment of fatigue in oncology care. Included within this review paper is an in-depth description of the proposed biological mechanisms of cancer-related fatigue, as well as a presentation of the 3P model’s application to this phenomenon. We conclude that a clinical focus on organization risk stratification and treatment around the 3P model may be warranted, and future research may benefit from expanding the 3P model to understand fatigue not only in oncology, but also across a variety of chronic conditions.

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Metadaten
Author:Alix G. SleightORCiD, Sylvia L. CrowderORCiD, Jacek Skarbinski, Paul Coen, Nathan H. Parker, Aasha I. HooglandORCiD, Brian D. GonzalezORCiD, Mary C. PlaydonORCiD, Steven Cole, Jennifer OseORCiDGND, Yuichi Murayama, Erin M. SiegelORCiD, Jane C. Figueiredo, Heather S. L. JimORCiD
URN:urn:nbn:de:bsz:960-opus4-31622
DOI:https://doi.org/10.25968/opus-3162
DOI original:https://doi.org/10.3390/cancers14081982
ISSN:2072-6694
Parent Title (English):Cancers
Publisher:MDPI
Document Type:Article
Language:English
Year of Completion:2022
Publishing Institution:Hochschule Hannover
Release Date:2024/07/08
Tag:fatigue; metabolomics; survivorship
GND Keyword:Erschöpfung; Metabolomik; Überleben; Krebs <Medizin>
Volume:14
Issue:8
Article Number:1982
Page Number:17
Institutes:Fakultät III - Medien, Information und Design
DDC classes:610 Medizin, Gesundheit
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International