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Longitudinal Associations of Adherence to the Dietary World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and Dutch Healthy Diet (DHD) Recommendations with Plasma Kynurenines in Colorectal Cancer Survivors after Treatment

  • The tryptophan-kynurenine pathway has been linked to cancer aetiology and survivorship, and diet potentially affects metabolites of this pathway, but evidence to date is scarce. Among 247 stage I-III CRC survivors, repeated measurements were performed at 6 weeks, 6 months, and 1 year post-treatment. Adherence to the World Cancer Research Fund/ American Institute for Cancer Research (WCRF) and Dutch Healthy Diet (DHD) recommendations was operationalized using seven-day dietary records. Plasma kynurenines of nine metabolites were analysed. Longitudinal associations of adherence to these dietary patterns and plasma kynurenines were analysed using confounder-adjusted linear mixed-models. In general, higher adherence to the dietary WCRF/AICR and DHD recommendations was associated with lower concentrations of kynurenines with pro-oxidative, pro-inflammatory, and neurotoxic properties (3-hydroxykynurenine (HK) and quinolinic acid (QA)), and higher concentrations of kynurenines with anti-oxidative, anti-inflammatory, and neuroprotective properties (kynurenic acid (KA) and picolinic acid (Pic)), but associations were weak and not statistically significant. Statistically significant positive associations between individual recommendations and kynurenines were observed for: nuts with kynurenic-acid-to-quinolinic-acid ratio (KA/QA); alcohol with KA/QA, KA, and xanthurenic acid (XA); red meat with XA; and cheese with XA. Statistically significant inverse associations were observed for: nuts with kynurenine-to-tryptophan ratio (KTR) and hydroxykynurenine ratio; alcohol with KTR; red meat with 3-hydroxyanthranilic-to-3-hydroxykynurenine ratio; ultra-processed foods with XA and KA/QA; and sweetened beverages with KA/QA. Our findings suggest that CRC survivors might benefit from adhering to the dietary WCRF and DHD recommendations in the first year after treatment, as higher adherence to these dietary patterns is generally, but weakly associated with more favourable concentrations of kynurenines and their ratios. These results need to be validated in other studies.

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Author:Daniëlle D. B. Holthuijsen, Martijn J. L. BoursORCiD, Eline H. van RoekelORCiD, Stéphanie O. BreukinkORCiD, Maryska L. G. Janssen-Heijnen, Eric T. P. KeulenORCiD, Per M. Ueland, Øivind Midttun, Stefanie Brezina, Biljana GigicORCiD, Andrea GsurORCiD, Dieuwertje E. KokORCiD, Jennifer OseORCiDGND, Cornelia M. Ulrich, Matty P. Weijenberg, Simone J. P. M. EussenORCiD
URN:urn:nbn:de:bsz:960-opus4-31612
DOI:https://doi.org/10.25968/opus-3161
DOI original:https://doi.org/10.3390/nu14235151
ISSN:2072-6643
Parent Title (English):Nutrients
Publisher:MDPI
Document Type:Article
Language:English
Year of Completion:2022
Publishing Institution:Hochschule Hannover
Release Date:2024/07/08
Tag:colorectal cancer survivorship; dietary patterns; dietary recommendations; kynurenines; lifestyle
GND Keyword:Dickdarmkrebs; Überleben; Lebensstil; Kynurenin; Ernährung; Empfehlungen für die Nährstoffzufuhr
Volume:14
Issue:23
Article Number:5151
Page Number:17
Institutes:Fakultät III - Medien, Information und Design
DDC classes:610 Medizin, Gesundheit
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International