TY  - JOUR
U1  - Wissenschaftlicher Artikel
A1  - Schiffner, Rebecca
A1  - Kostev, Karel
A1  - Gothe, Holger
T1  - Do patients with lactose intolerance exhibit more frequent comorbidities than patients without lactose intolerance? An analysis of routine data from German medical practices
JF  - Annals of Gastroenterology
N2  - Background:
The increase in food intolerances poses a burgeoning problem in our society. Food intolerances not only lead to physical impairment of the individual patient but also result in a high socio-economic burden due to factors such as the treatment required as well as absenteeism. The present study aimed to explore whether lactose intolerant (LI) patients exhibit more frequent comorbidities than non-LI patients.

Methods:
The study was conducted on a case-control basis and the results were determined using routine data analysis. Routine data from the IMS Disease Analyzer database were used for this purpose. A total of 6,758 data records were processed and analyzed.

Results:
There were significant correlations between LI and the incidence of osteoporosis, changes in mental status, and the presence of additional food intolerances. Comparing 3,379 LI vs. 3,379 non-LI patients, 34.5% vs. 17.7% (P<0.0001) suffered from abdominal pain; 30.6% vs. 17.2% (P<0.0001) from gastrointestinal infections; and 20.9% vs. 16.0% (P=0.0053) from depression. Adjusted odds ratios (OR) were the highest for fructose intolerance (n=229 LI vs. n=7 non-LI; OR 31.06; P<0.0001), irritable bowel syndrome (n=247 LI vs. n=44 non-LI; OR 5.23; P<0.0001), and bloating (n=351 LI vs. n=68 non-LI; OR 4.94; P<0.0001).

Conclusion:
The study confirms that LI should not be regarded as an isolated illness but considered a possible trigger for further diseases. Additional research is necessary to assert more precise statements.
KW  - Lactose intolerance
KW  - maldigestion
KW  - comorbidity
KW  - health services research
KW  - routine data
KW  - Lactoseintoleranz
KW  - Sekundärkrankheit
Y1  - 2016
UN  - https://nbn-resolving.org/urn:nbn:de:bsz:960-opus4-27324
SN  - 1792-7463
SS  - 1792-7463
U6  - https://doi.org/10.25968/opus-2732
DO  - https://doi.org/10.25968/opus-2732
VL  - 29
IS  - 2
SP  - 174
EP  - 179
ER  -