TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Zapf, Antonia
A1  - Albert, Christian
A1  - Frömke, Cornelia
A1  - Haase, Michael
A1  - Hoyer, Annika
A1  - Jones, Hayley E.
A1  - Rücker, Gerta
T1  - Meta-analysis of diagnostic accuracy studies with multiple thresholds: Comparison of different approaches
JF  - Biometrical Journal
N2  - Methods for standard meta-analysis of diagnostic test accuracy studies are well established and understood. For the more complex case in which studies report test accuracy across multiple thresholds, several approaches have recently been proposed. These are based on similar ideas, but make different assumptions. In this article, we apply four different approaches to data from a recent systematic review in the area of nephrology and compare the results. The four approaches use: a linear mixed effects model, a Bayesian multinomial random effects model, a time-to-event model and a nonparametric model, respectively. In the case study data, the accuracy of neutrophil gelatinase-associated lipocalin for the diagnosis of acute kidney injury was assessed in different scenarios, with sensitivity and specificity estimates available for three thresholds in each primary study. All approaches led to plausible and mostly similar summary results. However, we found considerable differences in results for some scenarios, for example, differences in the area under the receiver operating characteristic curve (AUC) of up to 0.13. The Bayesian approach tended to lead to the highest values of the AUC, and the nonparametric approach tended to produce the lowest values across the different scenarios. Though we recommend using these approaches, our findings motivate the need for a simulation study to explore optimal choice of method in various scenarios.
KW  - bivariate endpoint
KW  - meta-analysis
KW  - multiple thresholds
KW  - sensitivity
KW  - specificity
KW  - Metaanalyse
KW  - Diagnostik
KW  - Genauigkeit
KW  - Methode
KW  - Vergleich
Y1  - 2021
UN  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bsz:960-opus4-18496
U6  - https://dx.doi.org/10.25968/opus-1849
DO  - https://dx.doi.org/10.25968/opus-1849
SP  - 1
EP  - 13
ER  -