TY - JOUR U1 - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed) A1 - Ibeneme, Sam Chidi A1 - Irem, Franklin Onyedinma A1 - Iloanusi, Nneka Ifeyinwa A1 - Ezuma, Amarachi Destiny A1 - Ezenwankwo, Fortune Elochukwu A1 - Okere, Philip Chinedu A1 - Nnamani, Amaka Obiageli A1 - Ezeofor, Salome Nwaelom A1 - Dim, Ngozi Regina A1 - Fortwengel, Gerhard T1 - Impact of physical exercises on immune function, bone mineral density, and quality of life in people living with HIV/AIDS: a systematic review with meta-analysis JF - BMC Infectious Diseases N2 - Background: Compromised immune function, associated with human immune deficiency virus (HIV) infection, is improved by antiretroviral therapy (ART) which also decreases bone mineral density (BMD), and possibly the quality of life (QoL). However, physical (aerobic/resistance) exercises, were reported to induce reverse effects in uninfected individuals and were appraised in the literature for evidence of similar benefits in people living with HIV/AIDS(PLWHA). The main study objective was to evaluate the impact of physical (aerobic and resistance) exercises on CD4+ count, BMD and QoL in PLWHA. Methods: A systematic review was conducted using the Cochrane Collaboration protocol. Searching databases, up to June 2017, only randomized control trials investigating the effects of either aerobic, resistance or a combination of both exercise types with a control/other intervention(s) for a period of at least 4 weeks among adults living with HIV, were included. Two independent reviewers determined the eligibility of the studies. Data were extracted and risk of bias (ROB) was assessed with the Cochrane Collaboration ROB tool. Meta-analyses were conducted using random effect models using the Review Manager (RevMan) computer software. Results: Nineteen studies met inclusion criteria(n = 491 participants at study completion) comprising male and female with age range 22–66 years. Two meta-analyses across 13 sub-group comparisons were performed. However, there were no RCTs on the impact of physical exercises on BMD in PLWHA. The result showed no significant change in CD4+ count unlike a significant effect of 5.04 point (95%CI:-8.49,-3.74,p = 0.00001) for role activity limitation due to physical health (QoL sub-domain). Overall, the GRADE evidence for this review was of moderate quality. Conclusions: There was evidence that engaging in moderate intensity aerobic exercises (55–85% Maximum heart rate-MHR), for 30–60 min, two to five times/week for 6–24 weeks significantly improves role activity limitation due to physical health problems, otherwise physical(aerobic or/and resistance) exercises have no significant effects on CD4+ count and other domains of QoL. Also, there is lack of evidence on the impact of exercises on BMD in PLWHA due to the paucity of RCTs. The moderate grade evidence for this review suggests that further research may likely have an important impact on our confidence in the estimate of effects and may change the estimate. KW - Aerobic exercise KW - Resistance exercise KW - CD4+ cell count KW - Quality of Life KW - Systematic review KW - HIV KW - Aerobes Training KW - Lebensqualität KW - Krafttraining Y1 - 2019 UN - https://nbn-resolving.org/urn:nbn:de:bsz:960-opus4-13518 SN - 1471-2334 SS - 1471-2334 U6 - https://doi.org/10.25968/opus-1351 DO - https://doi.org/10.25968/opus-1351 VL - 2019 IS - 19:340 ER -