TY  - JOUR
U1  - Wissenschaftlicher Artikel
A1  - Leimbach, Stefanie
A1  - Nankemann, Franziska
A1  - Tellen, Anne
A1  - Klocke, Doris
A1  - Wente, Nicole
A1  - Zhang, Yanchao
A1  - Krömker, Volker
T1  - Retrospective Analysis of Penicillin G Minimum Inhibitory Concentration for Gram-Positive Isolates of Non-Severe Clinical Mastitis
JF  - Antibiotics
N2  - Background: Despite penicillin having a longstanding reputation as being scientifically approved for the treatment of bovine mastitis, its market share and practical application rate seem rather low. While in some countries, cases of mild and moderate mastitis are treated almost completely with simple penicillin, in other countries, penicillin is rarely used as a mono-substance in udder tubes.

Methods: Based on minimal inhibitory concentration (MIC) studies of 1489 isolates of Gram-positive microorganisms isolated from bovine mastitis cases, the extent to which penicillin preparations can fulfil their role as first-line treatment and in how many cases insufficient efficacy must be assumed was assessed in comparison with more recent studies on the achievable levels of active substances in milk.

Results: Of the isolates, 76% had an MIC of ≤0.125 µg/mL and 95% of the isolates had an MIC of ≤1 µg/mL.

Conclusions: The data show that in Northern Germany, it can be assumed that penicillin is a good choice in most cases of mastitis caused by Gram-positive mastitis pathogens, at least from the perspective of antibiotic resistance.
KW  - Penicilline
KW  - Euterentzündung
KW  - Gram-positive Bakterien
KW  - minimal inhibitory concentration
KW  - antimicrobial susceptibility
KW  - Gram-positive mastitis pathogens
KW  - procaine benzylpenicillin
KW  - Minimale Hemmkonzentration
Y1  - 2025
UN  - https://nbn-resolving.org/urn:nbn:de:bsz:960-opus4-34761
SN  - 2079-6382
SS  - 2079-6382
U6  - https://doi.org/10.25968/opus-3476
DO  - https://doi.org/10.25968/opus-3476
VL  - 14
IS  - 1
SP  - 7
S1  - 7
PB  - MDPI AG
ER  -