TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Ose, Jennifer
A1  - Fortner, R. T.
A1  - Schock, H.
A1  - Peeters, P. H.
A1  - Onland-Moret, N. C.
A1  - Bueno-de-Mesquita, H. B.
A1  - Weiderpass, E.
A1  - Gram, I. T.
A1  - Overvad, K.
A1  - Tjonneland, A.
A1  - Dossus, L
A1  - Fournier, A.
A1  - Baglietto, L.
A1  - Trichopoulou, A.
A1  - Benetou, V.
A1  - Trichopoulos, D.
A1  - Boeing, H.
A1  - Masala, G.
A1  - Krogh, V.
A1  - Matiello, A.
A1  - Tumino, R.
A1  - Popovic, M.
A1  - Obón-Santacana, M.
A1  - Larrañaga, N.
A1  - Ardanaz, E.
A1  - Sánchez, M.-J.
A1  - Menéndez, V.
A1  - Chirlaque, M.-D.
A1  - Travis, R. C.
A1  - Khaw, K.-T.
A1  - Brändstedt, J.
A1  - Idahl, A.
A1  - Lundin, E.
A1  - Rinaldi, S.
A1  - Kuhn, E.
A1  - Romieu, I.
A1  - Gunter, M. J.
A1  - Merritt, M. A.
A1  - Riboli, E.
A1  - Kaaks, R.
T1  - Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort
JF  - British Journal of Cancer
N2  - Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics.

Methods: We conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). Multivariable conditional logistic regression models were used to estimate associations.

Results: We observed no association between IGF-I and EOC overall or by tumour characteristics.

Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.
KW  - IGF-I
KW  - ovarian cancer
KW  - histological subtypes
KW  - carcinogenesis
KW  - type I/type II
KW  - dualistic pathway
KW  - Eierstockkrebs
KW  - Carcinogenese
Y1  - 2014
UN  - https://nbn-resolving.org/urn:nbn:de:bsz:960-opus4-31728
SN  - 1532-1827
SS  - 1532-1827
U6  - https://doi.org/10.25968/opus-3172
DO  - https://doi.org/10.25968/opus-3172
VL  - 112
SP  - 162
EP  - 166
ER  -