@article{RouraTravierWaterboeretal.2016,
  author    = {Roura, Esther and Travier, No{\´e}mie and Waterboer, Tim and Sanjos{\´e}, Silvia de and Bosch, F. Xavier and Pawlita, Michael and Pala, Valeria and Weiderpass, Elisabete and Margall, N{\´u}ria and Dillner, Joakim and Gram, Inger T. and Tj{\o}nneland, Anne and Munk, Christian and Palli, Domenico and Khaw, Kay-Tee and Overvad, Kim and Clavel-Chapelon, Fran{\c{c}}oise and Mesrine, Sylvie and Fournier, Agn{\`e}s and Fortner, Ren{\´e}e T. and Ose, Jennifer and Steffen, Annika and Trichopoulou, Antonia and Lagiou, Pagona and Orfanos, Philippos and Masala, Giovanna and Tumino, Rosario and Sacerdote, Carlotta and Polidoro, Silvia and Mattiello, Amalia and Lund, Eiliv and Peeters, Petra H. and Bueno-de-Mesquita, H. B. and Quir{\´o}s, J. Ram{\´o}n and S{\´a}nchez, Mar{\´i}a-Jos{\´e} and Navarro, Carmen and Barricarte, Aurelio and Larra{\~n}aga, Nerea and Ekstr{\"o}m, Johanna and Lindquist, David and Idahl, Annika and Travis, Ruth C. and Merritt, Melissa A. and Gunter, Marc J. and Rinaldi, Sabina and Tommasino, Massimo and Franceschi, Silvia and Riboli, Elio and Castellsagu{\´e}, Xavier},
  title     = {The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort},
  journal   = {PLoS ONE},
  volume    = {11},
  number    = {1},
  issn      = {1932-6203},
  doi       = {10.25968/opus-3171},
  institution = {Fakult{\"a}t III - Medien, Information und Design},
  pages     = {17},
  year      = {2016},
  abstract  = {Background: In addition to HPV, high parity and hormonal contraceptives have been associated with cervical cancer (CC). However, most of the evidence comes from retrospective case-control studies. The aim of this study is to prospectively evaluate associations between hormonal factors and risk of developing cervical intraepithelial neoplasia grade 3 (CIN3)/carcinoma in situ (CIS) and invasive cervical cancer (ICC). Methods and Findings: We followed a cohort of 308,036 women recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. At enrollment, participants completed a questionnaire and provided serum. After a 9-year median follow-up, 261 ICC and 804 CIN3/CIS cases were reported. In a nested case-control study, the sera from 609 cases and 1,218 matched controls were tested for L1 antibodies against HPV types 11,16,18,31,33,35,45,52,58, and antibodies against Chlamydia trachomatis and Human herpesvirus 2. Multivariate analyses were performed to estimate hazard ratios (HR), odds ratios (OR) and corresponding 95\% confidence intervals (CI). The cohort analysis showed that number of full-term pregnancies was positively associated with CIN3/CIS risk (p-trend = 0.03). Duration of oral contraceptives use was associated with a significantly increased risk of both CIN3/CIS and ICC (HR = 1.6 and HR = 1.8 respectively for ≥15 years versus never use). Ever use of menopausal hormone therapy was associated with a reduced risk of ICC (HR = 0.5, 95\%CI: 0.4-0.8). A non-significant reduced risk of ICC with ever use of intrauterine devices (IUD) was found in the nested case-control analysis (OR = 0.6). Analyses restricted to all cases and HPV seropositive controls yielded similar results, revealing a significant inverse association with IUD for combined CIN3/CIS and ICC (OR = 0.7). Conclusions: Even though HPV is the necessary cause of CC, our results suggest that several hormonal factors are risk factors for cervical carcinogenesis. Adherence to current cervical cancer screening guidelines should minimize the increased risk of CC associated with these hormonal risk factors.},
  subject      = {Hormon},
  language  = {en}
}