TY  - JOUR
U1  - Zeitschriftenartikel, wissenschaftlich - begutachtet (reviewed)
A1  - Papadimitriou, Nikos
A1  - Kim, Andre
A1  - Kawaguchi, Eric S.
A1  - Morrison, John
A1  - Diez-Obrero, Virginia
A1  - Albanes, Demetrius
A1  - Berndt, Sonja I.
A1  - Bézieau, Stéphane
A1  - Bien, Stephanie A.
A1  - Bishop, D Timothy
A1  - Bouras, Emmanouil
A1  - Brenner, Hermann
A1  - Buchanan, Daniel D.
A1  - Campbell, Peter T.
A1  - Carreras-Torres, Robert
A1  - Chan, Andrew T.
A1  - Chang-Claude, Jenny
A1  - Conti, David V.
A1  - Devall, Matthew A.
A1  - Dimou, Niki
A1  - Drew, David A.
A1  - Gruber, Stephen B.
A1  - Harrison, Tabitha A.
A1  - Hoffmeister, Michael
A1  - Huyghe, Jeroen R.
A1  - Joshi, Amit D.
A1  - Keku, Temitope O.
A1  - Kundaje, Anshul
A1  - Küry, Sébastien
A1  - Le Marchand, Loic
A1  - Lewinger, Juan Pablo
A1  - Li, Li
A1  - Lynch, Brigid M.
A1  - Moreno, Victor
A1  - Newton, Christina C.
A1  - Obón-Santacana, Mireia
A1  - Ose, Jennifer
A1  - Pellatt, Andrew J.
A1  - Peoples, Anita R.
A1  - Platz, Elizabeth A.
A1  - Qu, Conghui
A1  - Rennert, Gad
A1  - Ruiz-Narvaez, Edward
A1  - Shcherbina, Anna
A1  - Stern, Mariana C.
A1  - Su, Yu-Ru
A1  - Thomas, Duncan C.
A1  - Thomas, Claire E.
A1  - Tian, Yu
A1  - Tsilidis, Konstantinos K.
A1  - Ulrich, Cornelia M.
A1  - Um, Caroline Y.
A1  - Visvanathan, Kala
A1  - Wang, Jun
A1  - White, Emily
A1  - Woods, Michael O.
A1  - Schmit, Stephanie L.
A1  - Macrae, Finlay
A1  - Potter, John D.
A1  - Hopper, John L.
A1  - Peters, Ulrike
A1  - Murphy, Neil
A1  - Hsu, Li
A1  - Gunter, Marc J.
A1  - Gauderman, W. James
T1  - Genome-wide interaction study of dietary intake of fibre, fruits, and vegetables with risk of colorectal cancer
JF  - eBioMedicine
N2  - Background: Consumption of fibre, fruits and vegetables have been linked with lower colorectal cancer (CRC) risk. A genome-wide gene-environment (G × E) analysis was performed to test whether genetic variants modify these associations.

Methods: A pooled sample of 45 studies including up to 69,734 participants (cases: 29,896; controls: 39,838) of European ancestry were included. To identify G × E interactions, we used the traditional 1–degree-of-freedom (DF) G × E test and to improve power a 2-step procedure and a 3DF joint test that investigates the association between a genetic variant and dietary exposure, CRC risk and G × E interaction simultaneously.

Findings: The 3-DF joint test revealed two significant loci with p-value <5 × 10−8. Rs4730274 close to the SLC26A3 gene showed an association with fibre (p-value: 2.4 × 10−3) and G × fibre interaction with CRC (OR per quartile of fibre increase = 0.87, 0.80, and 0.75 for CC, TC, and TT genotype, respectively; G × E p-value: 1.8 × 10−7). Rs1620977 in the NEGR1 gene showed an association with fruit intake (p-value: 1.0 × 10−8) and G × fruit interaction with CRC (OR per quartile of fruit increase = 0.75, 0.65, and 0.56 for AA, AG, and GG genotype, respectively; G × E -p-value: 0.029).

Interpretation: We identified 2 loci associated with fibre and fruit intake that also modify the association of these dietary factors with CRC risk. Potential mechanisms include chronic inflammatory intestinal disorders, and gut function. However, further studies are needed for mechanistic validation and replication of findings.
KW  - Diet
KW  - Fibre
KW  - Gene-environment interaction
KW  - Colorectal cancer
KW  - GWAS
KW  - Ernährung
KW  - Ballaststoff
KW  - Dickdarmkrebs
KW  - Krebsrisiko
Y1  - 2024
UN  - https://nbn-resolving.org/urn:nbn:de:bsz:960-opus4-31499
SN  - 2352-3964
SS  - 2352-3964
U6  - https://doi.org/10.25968/opus-3149
DO  - https://doi.org/10.25968/opus-3149
VL  - 104
SP  - 14
S1  - 14
PB  - Elsevier
ER  -