@article{PapadimitriouKimKawaguchietal.2024,
  author    = {Nikos Papadimitriou and Andre Kim and Eric S. Kawaguchi and John Morrison and Virginia Diez-Obrero and Demetrius Albanes and Sonja I. Berndt and St{\´e}phane B{\´e}zieau and Stephanie A. Bien and D Timothy Bishop and Emmanouil Bouras and Hermann Brenner and Daniel D. Buchanan and Peter T. Campbell and Robert Carreras-Torres and Andrew T. Chan and Jenny Chang-Claude and David V. Conti and Matthew A. Devall and Niki Dimou and David A. Drew and Stephen B. Gruber and Tabitha A. Harrison and Michael Hoffmeister and Jeroen R. Huyghe and Amit D. Joshi and Temitope O. Keku and Anshul Kundaje and S{\´e}bastien K{\"u}ry and Loic Le Marchand and Juan Pablo Lewinger and Li Li and Brigid M. Lynch and Victor Moreno and Christina C. Newton and Mireia Ob{\´o}n-Santacana and Jennifer Ose and Andrew J. Pellatt and Anita R. Peoples and Elizabeth A. Platz and Conghui Qu and Gad Rennert and Edward Ruiz-Narvaez and Anna Shcherbina and Mariana C. Stern and Yu-Ru Su and Duncan C. Thomas and Claire E. Thomas and Yu Tian and Konstantinos K. Tsilidis and Cornelia M. Ulrich and Caroline Y. Um and Kala Visvanathan and Jun Wang and Emily White and Michael O. Woods and Stephanie L. Schmit and Finlay Macrae and John D. Potter and John L. Hopper and Ulrike Peters and Neil Murphy and Li Hsu and Marc J. Gunter and W. James Gauderman},
  title     = {Genome-wide interaction study of dietary intake of fibre, fruits, and vegetables with risk of colorectal cancer},
  series   = {eBioMedicine},
  volume    = {104},
  publisher = {Elsevier},
  issn      = {2352-3964},
  doi       = {10.25968/opus-3149},
  url       = {http://nbn-resolving.de/urn:nbn:de:bsz:960-opus4-31499},
  year      = {2024},
  abstract  = {Background: Consumption of fibre, fruits and vegetables have been linked with lower colorectal cancer (CRC) risk. A genome-wide gene-environment (G × E) analysis was performed to test whether genetic variants modify these associations. Methods: A pooled sample of 45 studies including up to 69,734 participants (cases: 29,896; controls: 39,838) of European ancestry were included. To identify G × E interactions, we used the traditional 1–degree-of-freedom (DF) G × E test and to improve power a 2-step procedure and a 3DF joint test that investigates the association between a genetic variant and dietary exposure, CRC risk and G × E interaction simultaneously. Findings: The 3-DF joint test revealed two significant loci with p-value <5 × 10−8. Rs4730274 close to the SLC26A3 gene showed an association with fibre (p-value: 2.4 × 10−3) and G × fibre interaction with CRC (OR per quartile of fibre increase = 0.87, 0.80, and 0.75 for CC, TC, and TT genotype, respectively; G × E p-value: 1.8 × 10−7). Rs1620977 in the NEGR1 gene showed an association with fruit intake (p-value: 1.0 × 10−8) and G × fruit interaction with CRC (OR per quartile of fruit increase = 0.75, 0.65, and 0.56 for AA, AG, and GG genotype, respectively; G × E -p-value: 0.029). Interpretation: We identified 2 loci associated with fibre and fruit intake that also modify the association of these dietary factors with CRC risk. Potential mechanisms include chronic inflammatory intestinal disorders, and gut function. However, further studies are needed for mechanistic validation and replication of findings.},
  language  = {en}
}