TY  - JOUR
U1  - Wissenschaftlicher Artikel
A1  - Himbert, Caroline
A1  - Figueiredo, Jane C.
A1  - Shibatha, David
A1  - Ose, Jennifer
A1  - Lin, Tengda
A1  - Huang, Lyen C.
A1  - Peoples, Anita R.
A1  - Scaife, Courtney L.
A1  - Pickron, Bartley
A1  - Lambert, Laura
A1  - Cohan, Jessica N.
A1  - Bronner, Mary
A1  - Felder, Seth
A1  - Sanchez, Julian
A1  - Dessureault, Sophie
A1  - Coppola, Domenico
A1  - Hoffman, David M.
A1  - Nasseri, Yosef F.
A1  - Decker, Robert W.
A1  - Zaghiyan, Karen
A1  - Murrell, Zuri A.
A1  - Hendifar, Andrew
A1  - Gong, Jun
A1  - Firoozmand, Eiman
A1  - Gangi, Alexandra
A1  - Moore, Beth A.
A1  - Cologne, Kyle G.
A1  - El-Masry, Maryliza S.
A1  - Hinkle, Nathan
A1  - Monroe, Justin
A1  - Mutch, Matthew
A1  - Bernadt, Cory
A1  - Chatterjee, Deyali
A1  - Sinanan, Mika
A1  - Cohen, Stacey A.
A1  - Wallin, Ulrike
A1  - Grady, William M.
A1  - Lampe, Paul D.
A1  - Reddi, Deepti
A1  - Krane, Mukta
A1  - Fichera, Alessandro
A1  - Moonka, Ravi
A1  - Herpel, Esther
A1  - Schirmacher, Peter
A1  - Kloor, Matthias
A1  - von Knebel-Doeberitz, Magnus
A1  - Nattenmueller, Johanna
A1  - Kauczor, Hans-Ulrich
A1  - Swanson, Eric
A1  - Jedrzkiewicz, Jolanta
A1  - Schmit, Stephanie L.
A1  - Gigic, Biljana
A1  - Ulrich, Alexis B.
A1  - Toriola, Adetunji T.
A1  - Siegel, Erin M.
A1  - Li, Christopher I.
A1  - Ulrich, Cornelia M.
A1  - Hardikar, Sheetal
T1  - Clinical Characteristics and Outcomes of Colorectal Cancer in the ColoCare Study: Differences by Age of Onset
JF  - Cancers
N2  - Early-onset colorectal cancer has been on the rise in Western populations. Here, we compare patient characteristics between those with early- (<50 years) vs. late-onset (≥50 years) disease in a large multinational cohort of colorectal cancer patients (n = 2193). We calculated descriptive statistics and assessed associations of clinicodemographic factors with age of onset using mutually-adjusted logistic regression models. Patients were on average 60 years old, with BMI of 29 kg/m2, 52% colon cancers, 21% early-onset, and presented with stage II or III (60%) disease. Early-onset patients presented with more advanced disease (stages III–IV: 63% vs. 51%, respectively), and received more neo and adjuvant treatment compared to late-onset patients, after controlling for stage (odds ratio (OR) (95% confidence interval (CI)) = 2.30 (1.82–3.83) and 2.00 (1.43–2.81), respectively). Early-onset rectal cancer patients across all stages more commonly received neoadjuvant treatment, even when not indicated as the standard of care, e.g., during stage I disease. The odds of early-onset disease were higher among never smokers and lower among overweight patients (1.55 (1.21–1.98) and 0.56 (0.41–0.76), respectively). Patients with early-onset colorectal cancer were more likely to be diagnosed with advanced stage disease, to have received systemic treatments regardless of stage at diagnosis, and were less likely to be ever smokers or overweight.
KW  - early onset
KW  - colorectal cancer
KW  - cohort
KW  - epidemiology
KW  - Dickdarmkrebs
KW  - Epidemiologie
Y1  - 2021
UN  - https://nbn-resolving.org/urn:nbn:de:bsz:960-opus4-30860
SN  - 2072-6694
SS  - 2072-6694
U6  - https://doi.org/10.25968/opus-3086
DO  - https://doi.org/10.25968/opus-3086
VL  - 13
IS  - 15
SP  - 13
S1  - 13
ER  -