@article{HimbertFigueiredoShibathaetal.2021,
  author    = {Himbert, Caroline and Figueiredo, Jane C. and Shibatha, David and Ose, Jennifer and Lin, Tengda and Huang, Lyen C. and Peoples, Anita R. and Scaife, Courtney L. and Pickron, Bartley and Lambert, Laura and Cohan, Jessica N. and Bronner, Mary and Felder, Seth and Sanchez, Julian and Dessureault, Sophie and Coppola, Domenico and Hoffman, David M. and Nasseri, Yosef F. and Decker, Robert W. and Zaghiyan, Karen and Murrell, Zuri A. and Hendifar, Andrew and Gong, Jun and Firoozmand, Eiman and Gangi, Alexandra and Moore, Beth A. and Cologne, Kyle G. and El-Masry, Maryliza S. and Hinkle, Nathan and Monroe, Justin and Mutch, Matthew and Bernadt, Cory and Chatterjee, Deyali and Sinanan, Mika and Cohen, Stacey A. and Wallin, Ulrike and Grady, William M. and Lampe, Paul D. and Reddi, Deepti and Krane, Mukta and Fichera, Alessandro and Moonka, Ravi and Herpel, Esther and Schirmacher, Peter and Kloor, Matthias and von Knebel-Doeberitz, Magnus and Nattenmueller, Johanna and Kauczor, Hans-Ulrich and Swanson, Eric and Jedrzkiewicz, Jolanta and Schmit, Stephanie L. and Gigic, Biljana and Ulrich, Alexis B. and Toriola, Adetunji T. and Siegel, Erin M. and Li, Christopher I. and Ulrich, Cornelia M. and Hardikar, Sheetal},
  title     = {Clinical Characteristics and Outcomes of Colorectal Cancer in the ColoCare Study: Differences by Age of Onset},
  journal   = {Cancers},
  volume    = {13},
  number    = {15},
  issn      = {2072-6694},
  doi       = {10.25968/opus-3086},
  institution = {Fakult{\"a}t III - Medien, Information und Design},
  pages     = {3817},
  year      = {2021},
  abstract  = {Early-onset colorectal cancer has been on the rise in Western populations. Here, we compare patient characteristics between those with early- (<50 years) vs. late-onset (≥50 years) disease in a large multinational cohort of colorectal cancer patients (n = 2193). We calculated descriptive statistics and assessed associations of clinicodemographic factors with age of onset using mutually-adjusted logistic regression models. Patients were on average 60 years old, with BMI of 29 kg/m2, 52\% colon cancers, 21\% early-onset, and presented with stage II or III (60\%) disease. Early-onset patients presented with more advanced disease (stages III-IV: 63\% vs. 51\%, respectively), and received more neo and adjuvant treatment compared to late-onset patients, after controlling for stage (odds ratio (OR) (95\% confidence interval (CI)) = 2.30 (1.82-3.83) and 2.00 (1.43-2.81), respectively). Early-onset rectal cancer patients across all stages more commonly received neoadjuvant treatment, even when not indicated as the standard of care, e.g., during stage I disease. The odds of early-onset disease were higher among never smokers and lower among overweight patients (1.55 (1.21-1.98) and 0.56 (0.41-0.76), respectively). Patients with early-onset colorectal cancer were more likely to be diagnosed with advanced stage disease, to have received systemic treatments regardless of stage at diagnosis, and were less likely to be ever smokers or overweight.},
  subject      = {Dickdarmkrebs},
  language  = {en}
}